{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:52:16Z","timestamp":1790610736552,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>It is important to identify cases of latent tuberculosis infection (LTBI) who are at risk for tuberculosis (TB) reactivation. We aimed to evaluate the performance of interferon (IFN)-gamma-inducible protein 10 (IP-10) as a marker to detect LTBI in patients with inflammatory rheumatic diseases (IRD). This study comprised 76 consecutive subjects with IRD. Patients with a history of TB or having active TB were excluded. In all patients, IP-10 level was measured and tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube test (QFT-GIT) were performed. Seventy patients with complete test results were analyzed. Twenty-one (30%) QFT-GIT-positive patients were defined as having LTBI. IP-10 yielded 2197 pg\/mL cut-off point. At this cut-off point, IP-10 showed 89% specificity with a sensitivity of 91% (AUC: 0.950, 95% CI 0.906\u20130.994). TST, QFT-GIT, and IP-10 were positive in 77.1%, 30%, and 44.3% of the patients, respectively. Concordance among the results of TST, QFT-GIT, and IP-10 tests was evaluated. Agreement was poor between IP-10 and TST (58.6%, \u03ba = 0.19), whereas it was good between QFT-GIT and IP-10 (84.3%, \u03ba = 0.65). The results of the present study demonstrated that sensitivity and specificity of released IP-10 were as high as those of QFT-GIT in indicating LTBI in IRD patient group.<\/jats:p>","DOI":"10.3390\/jpm12071027","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T22:43:00Z","timestamp":1656024180000},"page":"1027","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interferon-Inducible Protein-10 as a Marker to Detect Latent Tuberculosis Infection in Patients with Inflammatory Rheumatic Diseases"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-0080","authenticated-orcid":false,"given":"Mediha Gonenc","family":"Ortakoylu","sequence":"first","affiliation":[{"name":"Department of Pulmonary Disease, University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7006-5550","authenticated-orcid":false,"given":"Ayse","family":"Bahadir","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Disease, University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem","family":"Iliaz","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Disease, Koc University Hospital, Istanbul 34010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Soy Bugdayci","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Istanbul 34186, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Atilla","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Disease, University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan","family":"PAKER","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Istanbul 34186, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Tural Onur","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Disease, University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/resp.12067","article-title":"Challenges to the Global Control of Tuberculosis: Global Control of TB","volume":"18","author":"Chiang","year":"2013","journal-title":"Respirology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8909834","DOI":"10.1155\/2017\/8909834","article-title":"Risk of Tuberculosis Reactivation in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Receiving Non-Anti-TNF-Targeted Biologics","volume":"2017","author":"Cantini","year":"2017","journal-title":"Mediat. 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