{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:28:27Z","timestamp":1782790107595,"version":"3.54.5"},"reference-count":25,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Data to support the routine use of embolic protection devices for stroke prevention during transcatheter aortic valve replacement (TAVR) are controversial. Identifying patients at high risk for peri-procedural cerebrovascular events may facilitate effective patient selection for embolic protection devices during TAVR. Aim: To generate a risk score model for stratifying TAVR patients according to peri-procedural cerebrovascular events risk. Methods and results: A total of 8779 TAVR patients from 12 centers worldwide were included. Peri-procedural cerebrovascular events were defined as an ischemic stroke or a transient ischemic attack occurring \u226424 h from TAVR. The peri-procedural cerebrovascular events rate was 1.4% (n = 127), which was independently associated with 1-year mortality (hazards ratio (HR) 1.78, 95% confidence interval (CI) 1.06\u20132.98, p &lt; 0.028). The TASK risk score parameters were history of stroke, use of a non-balloon expandable valve, chronic kidney disease, and peripheral vascular disease, and each parameter was assigned one point. Each one-point increment was associated with a significant increase in peri-procedural cerebrovascular events risk (OR 1.96, 95% CI 1.56\u20132.45, p &lt; 0.001). The TASK score was dichotomized into very-low, low, intermediate, and high (0, 1, 2, 3\u20134 points, respectively). The high-risk TASK score group (OR 5.4, 95% CI 2.06\u201314.16, p = 0.001) was associated with a significantly higher risk of peri-procedural cerebrovascular events compared with the low TASK score group. Conclusions: The proposed novel TASK risk score may assist in the pre-procedural risk stratification of TAVR patients for peri-procedural cerebrovascular events.<\/jats:p>","DOI":"10.3390\/jpm12071056","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T01:48:38Z","timestamp":1656467318000},"page":"1056","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Predictors for Procedural Stroke and Implications for Embolic Protection Devices during TAVR: Results from the Multicenter Transcatheter Aortic Valve Replacement In-Hospital Stroke (TASK) Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-5296","authenticated-orcid":false,"given":"Anat","family":"Berkovitch","sequence":"first","affiliation":[{"name":"Interventional Cardiology Unit, Leviev Heart and Vascular Center, Chaim Sheba Medical Center, Ramat Gan 5262000, Israel"},{"name":"Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Segev","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Leviev Heart and Vascular Center, Chaim Sheba Medical Center, Ramat Gan 5262000, Israel"},{"name":"Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Maor","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Leviev Heart and Vascular Center, Chaim Sheba Medical Center, Ramat Gan 5262000, Israel"},{"name":"Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"},{"name":"Division of Cardiology, Tel Aviv Medical Center, Tel Aviv 69651, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0843-9240","authenticated-orcid":false,"given":"Matteo","family":"Saccocci","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Department, University Hospital of Zurich, CH-8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-8253","authenticated-orcid":false,"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"},{"name":"Division of Cardiology, Rabin Medical Center, Petach-Tikva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-343X","authenticated-orcid":false,"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Montefiore Medical Center, New York, NY 10467, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"De La Torre Hernandez","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department, Hospital Universitario Marques de Valdecilla, 39008 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"The Heart Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Mylotte","sequence":"additional","affiliation":[{"name":"University Hospital and SAOLTA Health Care Group, National University of Ireland, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Van Royen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Postbus 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azfar G.","family":"Zaman","sequence":"additional","affiliation":[{"name":"Cardiology, Freeman Hospital and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE1 7RU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Robert","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Clinique Pasteur, 31300 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Malte","family":"Sinning","sequence":"additional","affiliation":[{"name":"Heart Center Bonn, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"Steinvil","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"},{"name":"Division of Cardiology, Tel Aviv Medical Center, Tel Aviv 69651, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Department, University Hospital of Zurich, CH-8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Orvin","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel"},{"name":"Division of Cardiology, Rabin Medical Center, Petach-Tikva 49100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Iannopollo","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, San Raffaele Hospital, 10090 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"The Heart Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"De Backer","sequence":"additional","affiliation":[{"name":"University Hospital and SAOLTA Health Care Group, National University of Ireland, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Mercanti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Rome Tor Vergata, 00173 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-6510","authenticated-orcid":false,"given":"Kees","family":"van der Wulp","sequence":"additional","affiliation":[{"name":"Cardiology, Freeman Hospital and Institute 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