{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:23:38Z","timestamp":1780057418380,"version":"3.54.0"},"reference-count":73,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["2016\/25359-0"],"award-info":[{"award-number":["2016\/25359-0"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","award":["309045\/2018-5 (I.P.H.)"],"award-info":[{"award-number":["309045\/2018-5 (I.P.H.)"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["2016\/25359-0"],"award-info":[{"award-number":["2016\/25359-0"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["309045\/2018-5 (I.P.H.)"],"award-info":[{"award-number":["309045\/2018-5 (I.P.H.)"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014CAPES (F.G.R.)","award":["2016\/25359-0"],"award-info":[{"award-number":["2016\/25359-0"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014CAPES (F.G.R.)","award":["309045\/2018-5 (I.P.H.)"],"award-info":[{"award-number":["309045\/2018-5 (I.P.H.)"]}]},{"name":"Funda\u00e7\u00e3o Oswaldo Ramos\u2014Hospital do Rim (HRIM)","award":["2016\/25359-0"],"award-info":[{"award-number":["2016\/25359-0"]}]},{"name":"Funda\u00e7\u00e3o Oswaldo Ramos\u2014Hospital do Rim (HRIM)","award":["309045\/2018-5 (I.P.H.)"],"award-info":[{"award-number":["309045\/2018-5 (I.P.H.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Nephrolithiasis has been associated with bone loss and vascular calcification (VC), reflecting abnormal extraosseous calcium deposition. Fetuin-A (Fet-A) acts as a potent inhibitor of ectopic mineralization. The aim of the present study was to evaluate the prevalence of VC in stone formers (SF) and non-stone formers (NSF) and to investigate potential determinants of VC among SF, including circulating levels of Fet-A and bone microarchitecture parameters. Methods: Abdominal aortic calcification (AAC) was assessed using available computed tomography in SF and in age-, sex-, and BMI-matched NSF (potential living kidney donors). Serum Fet-A was measured in stored blood samples from SF. Bone microarchitecture parameters were obtained as a post hoc analysis of a cross-sectional cohort from young SF evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). Results: A total of 62 SF (38.0 [28.0\u201345.3] years old) and 80 NSF (40.0 [37.0\u201345.8] years old) were included. There was no significant difference in AAC scores between SF and NSF. However, when dividing SF according to mean AAC score, below &lt;5.8% (n = 33) or above \u22655.8% (n = 29), SF with higher AAC presented significantly higher BMI and tibial cortical porosity (Ct.Po) and significantly lower serum HDL, klotho, Fet-A, and eGFR. Urinary calcium did not differ between groups, but fractional excretion of phosphate was higher in the former. Upon multivariate regression, BMI, serum Fet-A, and tibial Ct.Po remained independently associated with AAC. Conclusions: This study suggests an association between reduced circulating Fet-A levels and increased bone Ct.Po with VC in SF.<\/jats:p>","DOI":"10.3390\/jpm12071120","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T22:48:00Z","timestamp":1657493280000},"page":"1120","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vascular Calcification Is Associated with Fetuin-A and Cortical Bone Porosity in Stone Formers"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-6869","authenticated-orcid":false,"given":"Fernanda Guedes","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Nutrition Post Graduation Program, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, Brazil"},{"name":"Department of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Fernandes Carvalho Azambuja","family":"Neves","sequence":"additional","affiliation":[{"name":"Hospital do Rim, Funda\u00e7\u00e3o Oswaldo Ramos, S\u00e3o Paulo 04038-002, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-5800","authenticated-orcid":false,"given":"Milene Subtil","family":"Ormanji","sequence":"additional","affiliation":[{"name":"Nephrology Division, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Ligeiro Gon\u00e7alves","family":"Esper","sequence":"additional","affiliation":[{"name":"Nephrology Division, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Hospital do Rim, Funda\u00e7\u00e3o Oswaldo Ramos, S\u00e3o Paulo 04038-002, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria Rodrigues","family":"Pereira","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Faculdade de Medicina, Universidade de S\u00e3o Paulo (USP), S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-9048","authenticated-orcid":false,"given":"Lucio R.","family":"Requi\u00e3o-Moura","sequence":"additional","affiliation":[{"name":"Hospital do Rim, Funda\u00e7\u00e3o Oswaldo Ramos, S\u00e3o Paulo 04038-002, Brazil"},{"name":"Nephrology Division, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-8733","authenticated-orcid":false,"given":"Martin H.","family":"de Borst","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0885-5877","authenticated-orcid":false,"given":"Ita Pfeferman","family":"Heilberg","sequence":"additional","affiliation":[{"name":"Nutrition Post Graduation Program, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, Brazil"},{"name":"Nephrology Division, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00240-020-01210-w","article-title":"Trends in the prevalence of kidney stones in the United States from 2007 to 2016","volume":"49","author":"Chewcharat","year":"2020","journal-title":"Urolithiasis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41581-020-0320-7","article-title":"Determining the true burden of kidney stone disease","volume":"16","author":"Thongprayoon","year":"2020","journal-title":"Nat. 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