{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:20:30Z","timestamp":1790914830350,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The aim of this study was to identify growth-restricted fetuses using biometric parameters and to assess the validity and clinical value of individual ultrasound parameters and ratios, such as transcerebellar diameter\/abdominal circumference (TCD\/AC), head circumference\/abdominal circumference (HC\/AC), and femur length\/abdominal circumference (FL\/AC). In a retrospective single-center cross-sectional study, the biometric data of 9292 pregnancies between the 15th and 42nd weeks of gestation were acquired. Statistical analysis included descriptive data, quantile regression estimating the 10th and 90th percentiles, and multivariable analysis. We obtained clinically noticeable results in predicting small-for-gestational-age (SGA) and fetal growth restriction (FGR) fetuses at advanced weeks of gestation using the AC with a Youden index of 0.81 and 0.96, respectively. The other individual parameters and quotients were less suited to identifying cases of SGA and FGR. The multivariable analysis demonstrated the best results for identifying SGA and FGR fetuses with an area under the curve of 0.95 and 0.96, respectively. The individual ultrasound parameters were better suited to identifying SGA and FGR than the ratios. Amongst these, the AC was the most promising individual parameter, especially at advanced weeks of gestation. However, the highest accuracy was achieved with a multivariable model.<\/jats:p>","DOI":"10.3390\/jpm12071125","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T21:57:53Z","timestamp":1657576673000},"page":"1125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fetal Growth Restriction: Comparison of Biometric Parameters"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7913-9894","authenticated-orcid":false,"given":"Carolin","family":"Marchand","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, St. Franziskus Hospital Muenster, 48145 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3640-2995","authenticated-orcid":false,"given":"Jeanette","family":"K\u00f6ppe","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0675-1262","authenticated-orcid":false,"given":"Helen Ann","family":"K\u00f6ster","sequence":"additional","affiliation":[{"name":"Practice of Gynecology and Obstetrics, Schlo\u00dfstra\u00dfe 107-8, 12163 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Oelmeier","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-8562","authenticated-orcid":false,"given":"Johannes","family":"Steinhard","sequence":"additional","affiliation":[{"name":"Department of Fetal Cardiology, Heart and Diabetes Center North Rhine-Westphalia, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-6049","authenticated-orcid":false,"given":"Arrigo","family":"Fruscalzo","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, HFR Fribourg, Chemin des Pensionnats 2-6, 1708 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-7111","authenticated-orcid":false,"given":"Karol","family":"Kubiak","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, St. Franziskus Hospital Muenster, 48145 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"ref_1","first-page":"165","article-title":"Predictive factors for intrauterine growth restriction","volume":"7","author":"Albu","year":"2014","journal-title":"J. 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