{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:51:27Z","timestamp":1772142687362,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>With the spread of oral implant therapy, serious medical complications related to implant surgery are becoming a social problem. Although the number of complications after implant surgery in the edentulous jaw is decreasing in Japan, maxillary-sinus-related complications (MSRCs) have reached the highest number since 2012. It is essential to identify and eliminate possible predisposing risk factors for MSRCs at an early stage to prevent MSRCs. In this review article, we highlight the causal factors of postoperative complications with or without sinus augmentation for the maxillary molar region to achieve optimal treatment outcomes and reduce complications. In particular, we focus on anatomical variations that can cause the impairment of maxillary sinus drainage. Furthermore, we emphasize that the paradigm for personalized medicine for patients with a maxillary edentulous jaw by ENT specialist and dentist cooperation is shifting from the traditional assessment of maxillary sinus pathologies alone to the new assessment of anatomic variations that can cause the impairment of maxillary sinus drainage in addition to maxillary sinus pathologies.<\/jats:p>","DOI":"10.3390\/jpm12081289","type":"journal-article","created":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T22:51:46Z","timestamp":1659912706000},"page":"1289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Proposal for a Paradigm Shift in Personalized Medicine for Patients with a Maxillary Edentulous Jaw by ENT Specialist and Dentist Cooperation"],"prefix":"10.3390","volume":"12","author":[{"given":"Yuh","family":"Baba","sequence":"first","affiliation":[{"name":"Department of General Clinical Medicine, Ohu University School of Dentistry, 31-1, Mitsumido, Tomita-machi, Koriyama City 963-8611, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-9324","authenticated-orcid":false,"given":"Yasumasa","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Oral Function and Molecular Biology, Ohu University School of Dentistry, 31-1, Mitsumido, Tomita-machi, Koriyama City 963-8611, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-2452","authenticated-orcid":false,"given":"Keiso","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Periodontics, Department of Conservative Dentistry, Ohu University School of Dentistry, 31-1, Mitsumido, Tomita-machi, Koriyama City 963-8611, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12278","article-title":"Concepts for prevention of complications in implant therapy","volume":"81","author":"Romanos","year":"2019","journal-title":"Periodontol. 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.joms.2017.07.152","article-title":"Floor-of-mouth hematoma following dental implant placement: Literature Review and Case Presentation","volume":"75","author":"Law","year":"2017","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_3","first-page":"1100","article-title":"A maxillary sinusitis after sinus lift surgery","volume":"4","author":"Suzuki","year":"2018","journal-title":"J. Dent. Oral. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.ijom.2009.09.001","article-title":"The management of complications following displacement of oral implants in the paranasal sinuses: A multicenter clinical report and proposed treatment protocols","volume":"38","author":"Chiapasco","year":"2009","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_5","unstructured":"Working Group of Trouble Investigation of The Japanese Academy of Maxillofacial Implants (2012). Severe medical complications related dental implant surgery-The first investigative report in Japan. Jpn. J. Maxillo. Facial. Implants, 11, 31\u201339. (In Japanese)."},{"key":"ref_6","first-page":"89","article-title":"Severe medical complications related dental implant surgery-The second investigative report in Japan","volume":"16","author":"Usuda","year":"2017","journal-title":"Jpn. J. Maxillo. Facial. Implant."},{"key":"ref_7","first-page":"111","article-title":"Severe medical complications relating dental implant surgery-The third investigative report in Japan","volume":"19","author":"Fuchigami","year":"2020","journal-title":"Jpn. J. Maxillo. Facial. Implant."},{"key":"ref_8","first-page":"28","article-title":"Effect of schneiderian membrane perforation on posterior maxillary implant survival","volume":"5","author":"Nooh","year":"2013","journal-title":"J. Int. Oral Health."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/jcpe.12724","article-title":"Association between diabetes mellitus\/hyperglycaemia and peri-implant diseases: Systematic review and meta-analysis","volume":"44","author":"Monje","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S267","DOI":"10.1002\/JPER.16-0350","article-title":"Peri-implantitis","volume":"89","author":"Schwarz","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/lary.20992","article-title":"A systematic analysis of septal deviation associated with rhinosinusitis","volume":"120","author":"Orlandi","year":"2010","journal-title":"Laryngoscope"},{"key":"ref_12","first-page":"244","article-title":"Multiparametric statistical correlations between paranasal sinus anatomic variations and chronic rhinosinusitis","volume":"32","author":"Fadda","year":"2012","journal-title":"Acta. Otorhinolaryngol. Ital."},{"key":"ref_13","first-page":"163","article-title":"Accessory maxillary ostia: Prevalence of an anatomical variant and association with chronic sinusitis","volume":"8","author":"Aleshawi","year":"2020","journal-title":"Int. J. Gen. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"278","DOI":"10.5125\/jkaoms.2016.42.5.278","article-title":"Correlations between anatomic variations of maxillary sinus ostium and postoperative complication after sinus lifting","volume":"42","author":"Lee","year":"2016","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.bjoms.2019.04.013","article-title":"Correlation between prevelance of Haller cells and postoperative maxillary sinusitis after sinus lifting procedure","volume":"57","author":"Akbulut","year":"2019","journal-title":"Br. J. Oral. Maxillofac. Surg."},{"key":"ref_16","first-page":"6869805","article-title":"A successful treatment regimen for the prevention of sinusitis after maxillary sinus floor elevation surgery in a high-risk case","volume":"2020","author":"Takahashi","year":"2020","journal-title":"Case Rep. Otolaryngol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1177\/0194599819829747","article-title":"What affects postoperative sinusitis and implant failure after dental implant: A meta-analysis","volume":"160","author":"Kim","year":"2019","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/alr.21177","article-title":"Cysts of the maxillary sinus: A literature review","volume":"3","author":"Giotakis","year":"2013","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.4317\/medoral.24155","article-title":"Are mucous retention cysts and pseudocysts in the maxillary sinus a risk factor for dental implants? A systematic review","volume":"26","author":"Anitua","year":"2021","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/ID.0b013e3182341f79","article-title":"Sinus pathology and anatomy in relation to complications in lateral window sinus augmentation","volume":"20","author":"Chan","year":"2011","journal-title":"Implant. Dent."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/lary.26856","article-title":"A paradigm for evaluation and management of the maxillary sinus before dental implantation","volume":"128","author":"Chen","year":"2018","journal-title":"Laryngoscope"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2500\/aap.2019.40.4252","article-title":"Nasal polyps and rhinosinusitis","volume":"40","author":"Kwah","year":"2019","journal-title":"Allergy Asthma Proc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1055\/s-0041-1730456","article-title":"Analysis of ear, nose and throat Manifestations in COVID-19 Patients","volume":"25","author":"Eesa","year":"2021","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/ID.0b013e3182310dd0","article-title":"Sinus augmentation surgery after endoscopic sinus surgery for the treatment of chronic maxillary sinusitis: A case report","volume":"20","author":"Tobita","year":"2011","journal-title":"Implant Dent."},{"key":"ref_25","first-page":"244","article-title":"Osteomas of the paranasal sinuses: Surgical treatment options","volume":"13","author":"Strek","year":"2007","journal-title":"Med. Sci. Monit."},{"key":"ref_26","first-page":"195","article-title":"Eosinophilic sinusitis","volume":"44","author":"Haruna","year":"2001","journal-title":"Oto-Rhino-Laryngol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"555894","DOI":"10.19080\/ADOH.2021.14.555894","article-title":"Different management for patients with two types of chronic rhinosinusitis for their oral implant therapy","volume":"14","author":"Takahashi","year":"2021","journal-title":"Adv. Dent. Oral Health"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"106370","DOI":"10.1016\/j.ijscr.2021.106370","article-title":"The importance of early detection for postoperative maxillary cyst before dental implantation: A case report","volume":"86","author":"Funakawa","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"346","DOI":"10.5051\/jpis.2019.49.6.346","article-title":"Points to consider before the insertion of maxillary implants: The otolaryngologist\u2019s perspective","volume":"49","author":"Kim","year":"2019","journal-title":"J. Periodontal. Implant. Sci."},{"key":"ref_30","first-page":"110","article-title":"ENT assessment in the integrated management of candidate for (maxillary) sinus lift","volume":"28","author":"Pignataro","year":"2008","journal-title":"Acta. Otorhinolaryngol. Ital."},{"key":"ref_31","first-page":"889","article-title":"Sinus slot technique for simplification and improved orientation of zygomaticus dental implants: A technical note","volume":"15","author":"Stella","year":"2000","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1002\/hed.26347","article-title":"Respiratory droplet generation and dispersal during nasoendoscopy and upper respiratory swab testing","volume":"42","author":"Tan","year":"2020","journal-title":"Head Neck"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.3390\/s21217402","article-title":"Diagnostic Accuracy of Cystic Lesions Using a Pre-Programmed Low-Dose and Standard-Dose Dental Cone-Beam Computed Tomography Protocol: An Ex Vivo Comparison Study","volume":"21","author":"Wiedemeier","year":"2021","journal-title":"Sensors"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3390\/jimaging8050146","article-title":"Dental MRI of Oral Soft-Tissue Tumors-Optimized Use of Black Bone MRI Sequences and a 15-Channel Mandibular Coil","volume":"8","author":"Sekerci","year":"2022","journal-title":"J. Imaging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0501.2010.01986.x","article-title":"Antral computerized tomography pre-operative evaluation: Relationship between mucosal thickening and maxillary sinus function","volume":"22","author":"Carmeli","year":"2011","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/clr.12168","article-title":"Cone-beam computed tomographic analysis of sinus membrane thickness, ostium patency, and residual ridge heights in the posterior maxilla: Implications for sinus floor elevation","volume":"25","author":"Shanbhag","year":"2014","journal-title":"Clin. Oral Implant. Res."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/8\/1289\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:04:36Z","timestamp":1760141076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/8\/1289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":36,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["jpm12081289"],"URL":"https:\/\/doi.org\/10.3390\/jpm12081289","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]}}}