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Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making.<\/jats:p>","DOI":"10.3390\/jpm12091410","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:13:56Z","timestamp":1661904836000},"page":"1410","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-3553","authenticated-orcid":false,"given":"Sandrine","family":"Morel","sequence":"first","affiliation":[{"name":"Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9004-2540","authenticated-orcid":false,"given":"Isabel C.","family":"Hostettler","sequence":"additional","affiliation":[{"name":"Stroke Research Centre, University College London Queen Square Institute of Neurology, London WC1N 3BG, UK"},{"name":"Department of Neurosurgery, Canton Hospital St. Gallen, 9000 St. Gallen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg R.","family":"Spinner","sequence":"additional","affiliation":[{"name":"ZHAW School of Life Sciences and Facility Management, 8820 W\u00e4denswil, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Hospital Centre Nantes, University of Nantes, L\u2019institut Du Thorax, 44007 Nantes, France"},{"name":"Department of Neuroradiology, University Hospital of Nantes, 44000 Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6142-2969","authenticated-orcid":false,"given":"Joanna","family":"Pera","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, ul. 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