{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T17:21:13Z","timestamp":1763400073077,"version":"build-2065373602"},"reference-count":101,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Electronic Waveform Lab Inc.","award":["1101 CX002099-01"],"award-info":[{"award-number":["1101 CX002099-01"]}]},{"name":"R41 MD012318\/MD\/NIMHD NIH HHS\/United States","award":["1101 CX002099-01"],"award-info":[{"award-number":["1101 CX002099-01"]}]},{"name":"Veterans Administration","award":["1101 CX002099-01"],"award-info":[{"award-number":["1101 CX002099-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Addiction is a complex multifactorial condition. Established genetic factors can provide clear guidance in assessing the risk of addiction to substances and behaviors. Chronic stress can accumulate, forming difficult to recognize addiction patterns from both genetic and epigenetic (environmental) factors. Furthermore, psychological\/physical\/chemical stressors are typically categorized linearly, delaying identification and treatment. The patient in this case report is a Caucasian female, aged 36, who presented with chronic pain and partial disability following a surgically repaired trimalleolar fracture. The patient had a history of unresolved attention deficit disorder and an MRI scan of her brain revealed atrophy and functional asymmetry. In 2018, the patient entered the Bajaj Chiropractic Clinic, where initial treatment focused on re-establishing integrity of the spine and lower extremity biomechanics and graduated into cognitive behavior stabilization assisted by DNA pro-dopamine regulation guided by Genetic Addiction Risk Severity testing. During treatment (2018\u20132021), progress achieved included: improved cognitive clarity, focus, sleep, anxiety, and emotional stability in addition to pain reduction (75%); elimination of powerful analgesics; and reduced intake of previously unaddressed alcoholism. To help reduce hedonic addictive behaviors and pain, coupling of H-Wave with corrective chiropractic care seems prudent. We emphasize the importance of genetic assessment along with attempts at inducing required dopaminergic homeostasis via precision KB220PAM. It is hypothesized that from preventive care models, a new standard is emerging including self-awareness and accountability for reward deficiency as a function of hypodopaminergia. This case study documents the progression of a patient dealing with the complexities of an injury, pain management, cognitive impairment, anxiety, depression, and the application of universal health principles towards correction versus palliative care.<\/jats:p>","DOI":"10.3390\/jpm12091416","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:13:56Z","timestamp":1661904836000},"page":"1416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave\u00ae and Other Neurobiologically Based Modalities to Address Complexities of Chronic Pain in a Female Diagnosed with Reward Deficiency Syndrome (RDS): Emergence of Induction of \u201cDopamine Homeostasis\u201d in the Face of the Opioid Crisis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-6740","authenticated-orcid":false,"given":"Anish","family":"Bajaj","sequence":"first","affiliation":[{"name":"Bajaj Chiropractic Clinic, New York, NY 10010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-803X","authenticated-orcid":false,"given":"Kenneth","family":"Blum","sequence":"additional","affiliation":[{"name":"Division of Addiction Research & Education, Center for Psychiatry, Medicine, and Primary Care, (Office of the Provost), Western University Health Sciences, Pomona, CA 91766, USA"},{"name":"The Kenneth Blum Institute on Behavior & Neurogenetics, Austin, TX 78701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-0688","authenticated-orcid":false,"given":"Abdalla","family":"Bowirrat","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-2755","authenticated-orcid":false,"given":"Ashim","family":"Gupta","sequence":"additional","affiliation":[{"name":"Future Biologics, Lawrenceville, GA 30043, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baron","sequence":"additional","affiliation":[{"name":"Division of Addiction Research & Education, Center for Psychiatry, Medicine, and Primary Care, (Office of the Provost), Western University Health Sciences, Pomona, CA 91766, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Fugel","sequence":"additional","affiliation":[{"name":"Bajaj Chiropractic Clinic, New York, NY 10010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayo","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Bajaj Chiropractic Clinic, New York, NY 10010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Fitch","sequence":"additional","affiliation":[{"name":"Bajaj Chiropractic Clinic, New York, NY 10010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2096-8265","authenticated-orcid":false,"given":"B. William","family":"Downs","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-6427","authenticated-orcid":false,"given":"Debasis","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Southern University College of Pharmacy, Houston, TX 77004, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Dennen","sequence":"additional","affiliation":[{"name":"The Kenneth Blum Institute on Behavior & Neurogenetics, Austin, TX 78701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5586-5114","authenticated-orcid":false,"given":"Rajendra D.","family":"Badgaiyan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, South Texas Veteran Health Care System, Audie L. 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