{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:22:45Z","timestamp":1778325765141,"version":"3.51.4"},"reference-count":18,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Age-related macular degeneration (AMD) is a progressive, degenerative disease of the central retina. AMD is subdivided into \u201cdry\u201d (atrophic), \u201cwet\u201d (exudative), and neovascular (nAMD) forms. In recent years, the concepts about nAMD changed with the development of optical coherence tomography\u2013angiography (OCT-A) and intravitreal anti-VEGF treatment. The aim of this study was to define the morphologic type of the neovascular membrane (NVM) before treatment with OCT-A and to register vascular remodeling after treatment with anti-VEGF. We also analyzed the relationship between NVM and visual acuity. Methods: The study was retrospective and included 119 patients with newly diagnosed, treatment-na\u00efve nAMD. All the patients underwent full ophthalmic examination and also fluoresceine angiography and optical coherence tomography\u2013angiography (OCT-A). Results: Based on the collected data, we found repetitive regularities. Conclusion: The analysis of our results could be used as prognostic markers for the evolution of the disease and as a basis for new treatment strategies, depending on the na\u00efve NVM morphologic type.<\/jats:p>","DOI":"10.3390\/jpm12091456","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T22:33:01Z","timestamp":1662503581000},"page":"1456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Personalized Approach in Treatment of Neovascular Age-Related Macular Degeneration"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1712-9877","authenticated-orcid":false,"given":"Radina","family":"Kirkova","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, ENT and Maxillofacial Surgery, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"},{"name":"Department of Ophthalmology, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7413-8614","authenticated-orcid":false,"given":"Snezhana","family":"Murgova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, ENT and Maxillofacial Surgery, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"},{"name":"Department of Ophthalmology, University Hospital Dr. Georgi Stranski, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidin","family":"Kirkov","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, Faculty of Public Health \u201cProf. Dr. Tzekomir Vodenicharov\u201d, Medical University of Sofia, 1000 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Tanev","sequence":"additional","affiliation":[{"name":"Eye Clinic \u201cZrenie\u201d, 1000 Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","article-title":"Global estimates of visual impairment: 2010","volume":"96","author":"Mariotti","year":"2012","journal-title":"Br. 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A new diagnostic challenge","volume":"35","author":"Coscas","year":"2015","journal-title":"Retina"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"de Almodovar, C.R., Ny, A., Carmeliet, P., King, G.L., Suzuma, K., Sun, J.K., Agostini, H., and Martin, G. (2007). Retinal Angiogenesis and Growth Factors. Retinal Vascular Disease, Springer.","DOI":"10.1007\/978-3-540-29542-6_3"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1364\/BOE.2.001184","article-title":"In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)","volume":"2","author":"Enfield","year":"2011","journal-title":"Biomed. Opt. 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