{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:09:42Z","timestamp":1790024982433,"version":"4.0.1"},"reference-count":100,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Reactive oxygen species (ROS) and free radicals, which have been implicated in inflammation, pain, carcinogenesis, and aging, are actually used in dental treatments such as tooth bleaching and composite resin polymerization. Recently, numerous studies have investigated the application of ROS in the medical and dental fields. In previous studies, ROS were generated intentionally through pathways such as photolysis, photocatalytic methods, and photodynamic therapy, which are used in the medical field to target cancer. In the field of dentistry, generated ROS are applied mainly for periodontal treatment and sterilization of the root canal, and its effectiveness as an antibacterial photodynamic therapy has been widely reported.. Given this background, the present article aimed to review the basic effects of ROS in dental medicine, especially endodontic therapy, and to discuss future applications of ROS.<\/jats:p>","DOI":"10.3390\/jpm12091531","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T02:06:50Z","timestamp":1663553210000},"page":"1531","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Application of Reactive Oxygen Species in Dental Treatment"],"prefix":"10.3390","volume":"12","author":[{"given":"Chiaki","family":"Komine","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Dentistry for the Compromised Patient, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Uchibori","sequence":"additional","affiliation":[{"name":"Department of Oral Function and Fixed Prothodontics, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Tsudukibashi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Dentistry for the Compromised Patient, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhisa","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. 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