{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:14:20Z","timestamp":1782422060947,"version":"3.54.5"},"reference-count":54,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chang Gung Memorial Hospital","award":["CMRPG3L0861"],"award-info":[{"award-number":["CMRPG3L0861"]}]},{"name":"Chang Gung Memorial Hospital","award":["CMRPG3J0593"],"award-info":[{"award-number":["CMRPG3J0593"]}]},{"name":"Chang Gung Memorial Hospital","award":["CMRPG3M1101"],"award-info":[{"award-number":["CMRPG3M1101"]}]},{"name":"Chang Gung Memorial Hospital","award":["CMRPB53"],"award-info":[{"award-number":["CMRPB53"]}]},{"name":"Chang Gung Memorial Hospital","award":["MOST 110-2314-B-182-045-MY3"],"award-info":[{"award-number":["MOST 110-2314-B-182-045-MY3"]}]},{"name":"Ministry of Science and Technology","award":["CMRPG3L0861"],"award-info":[{"award-number":["CMRPG3L0861"]}]},{"name":"Ministry of Science and Technology","award":["CMRPG3J0593"],"award-info":[{"award-number":["CMRPG3J0593"]}]},{"name":"Ministry of Science and Technology","award":["CMRPG3M1101"],"award-info":[{"award-number":["CMRPG3M1101"]}]},{"name":"Ministry of Science and Technology","award":["CMRPB53"],"award-info":[{"award-number":["CMRPB53"]}]},{"name":"Ministry of Science and Technology","award":["MOST 110-2314-B-182-045-MY3"],"award-info":[{"award-number":["MOST 110-2314-B-182-045-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Patients affected by oral tongue squamous cell carcinoma (OTSCC) underwent a supraomohyoid neck dissection (SOHND) or modified radical neck dissection (mRND) according to the clinical nodal status (cN0 vs. cN+). We investigate whether the type of neck dissection affects survival with the presence of extranodal extension (ENE) and multiple nodal metastases (MNM). Methods: We conducted a retrospective study enrolling surgically treated patients affected by cT1\/T2 OTSCC and MNM or ENE. The outcomes assessed were: overall survival (OS), disease-free survival (DFS), and neck-control- and metastases-free survival (NC-MFS). Survival curves were plotted by the Kaplan\u2013Meier method and the log-rank test. Furthermore, we conducted a multivariable analysis with the Cox regression model. Results: We included a total of 565 patients (36% cT1, 64% cT2). Of these, 501 patients underwent a SOHND, and 64 underwent an mRND. A total of 184 patients presented rpN+, with 28.7% of these in the SOHND group and 62.5% of these in the mRND group. We identified no significant differences in OS, DFS, and NC-MFS in the whole pN+ cohort, in the MNM, and the ENE subgroups. In the multivariable analysis, the type of ND did not affect OS and DFS. Conclusions: Treating cT1-2 N0\/+ tongue cancer with SOHND is oncologically safe. ENE and MNM patients do not benefit from an mRND.<\/jats:p>","DOI":"10.3390\/jpm12091535","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T21:47:27Z","timestamp":1663624047000},"page":"1535","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1\/T2 Tongue Cancer"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-3045","authenticated-orcid":false,"given":"Andrea","family":"Iandelli","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Branch, Yaoyuan 33302, Taiwan"},{"name":"Unit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7997-964X","authenticated-orcid":false,"given":"Filippo","family":"Marchi","sequence":"additional","affiliation":[{"name":"Unit of Otorhinolaryngology-Head and Neck Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16132 Genova, Italy"},{"name":"Department of Plastic Surgery, Chang Gung Memorial, Linkou Branch, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Branch, Yaoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Kuan","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial, Keelung Branch, Keelung 20401, Taiwan"},{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ta","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Branch, Yaoyuan 33302, Taiwan"},{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Kan","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Chang Gung Memorial, Linkou Branch, Taoyuan 333, Taiwan"},{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-9396","authenticated-orcid":false,"given":"Chung-Jan","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Branch, Yaoyuan 33302, Taiwan"},{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Medical Oncology, Internal Medicine, Chang Gung Memorial, Linkou Branch, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Chieh Joseph","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Radiation Oncology, Chang Gung Memorial, Linkou Branch, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-9938","authenticated-orcid":false,"given":"Shiang-Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou Branch, Yaoyuan 33302, Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, Chang Gun Medical College, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00428-021-03063-z","article-title":"The prognostic role of histologic grade, worst pattern of invasion, and tumor budding in early oral tongue squamous cell carcinoma: A comparative study","volume":"47","author":"Xu","year":"2021","journal-title":"Virchows Arch. 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