{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:42:06Z","timestamp":1790023326627,"version":"4.0.1"},"reference-count":69,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Previous systematic reviews have reported that coronally advanced flap (CAF) + connective tissue graft (CTG) are the gold standard in root coverage procedures (RCP). Nevertheless, adjunctive treatment with hyaluronic acid (HA) has been proposed to aim at improving clinical outcomes and reducing patient morbidity. The aim of this systematic review and meta-analysis is to compare the use of HA as an adjunctive treatment to CAF procedures in Miller class I and II (recession type 1; RT1) gingival recession (GR) defects treatment with no adjunctive\/other treatments. MEDLINE, The Cochrane Central Register of Controlled Trials, Web of Science, Scopus databases and gray literature were searched up to April 2022. The primary outcome variables were mean recession coverage (MRC) and reduction of the recession depth (RecRed). Weighted mean differences and 95% confidence intervals between treatments were estimated using a random-effect mode. From 264 titles identified, 3 RCTs reporting 90 GR defects in 60 patients were included. Overall analysis of MRC and RecRed were 0.27% (p = 0.01) and 0.40 mm (p = 0.45) in favor of CAF + HA compared to CAF alone\/CAF + subepithelial connective tissue graft (SCTG), respectively, with a statistically significant difference only for MRC values. Nevertheless, due to the limited number and heterogeneity of the included studies, well-performed RCTs are needed to clarify a potential advantage of HA in RCPs in the future.<\/jats:p>","DOI":"10.3390\/jpm12091539","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T21:47:27Z","timestamp":1663624047000},"page":"1539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hyaluronic Acid as an Adjunct to Coronally Advanced Flap Procedures for Gingival Recessions: A Systematic Review and Meta\u2014Analysis of Randomized Clinical Trials"],"prefix":"10.3390","volume":"12","author":[{"given":"Mariana A.","family":"Rojas","sequence":"first","affiliation":[{"name":"Section of Periodontics, Department of Oral and Maxillo-Facial Sciences, Sapienza, University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6662-2644","authenticated-orcid":false,"given":"Lorenzo","family":"Marini","sequence":"additional","affiliation":[{"name":"Section of Periodontics, Department of Oral and Maxillo-Facial Sciences, Sapienza, University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Sahrmann","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontology and Cariology, University Centre for Dental Medicine, University of Basel, 4058 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pilloni","sequence":"additional","affiliation":[{"name":"Section of Periodontics, Department of Oral and Maxillo-Facial Sciences, Sapienza, University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1902\/annals.1999.4.1.98","article-title":"Mucogingival deformities","volume":"4","year":"1999","journal-title":"Ann. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S204","DOI":"10.1002\/JPER.16-0671","article-title":"Mucogingival conditions in the natural dentition: Narrative review, case definitions, and diagnostic considerations","volume":"89","author":"Cortellini","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.14219\/jada.archive.2003.0137","article-title":"The etiology and prevalence of gingival recession","volume":"134","author":"Kassab","year":"2003","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1902\/jop.2017.160767","article-title":"Long-Term Stability of Root Coverage by Coronally Advanced Flap Procedures","volume":"88","author":"Jepsen","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1601-6343.2010.01491.x","article-title":"Orthodontic therapy and gingival recession: A systematic review","volume":"13","author":"Grebenstein","year":"2010","journal-title":"Orthod. Craniofac. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/prd.12115","article-title":"Management and prevention of gingival recession","volume":"71","author":"Merijohn","year":"2016","journal-title":"Periodontology 2000"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1902\/jop.1993.64.9.900","article-title":"Gingival recession in relation to history of hard toothbrush use","volume":"64","author":"Khocht","year":"1993","journal-title":"J. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-051X.1994.tb00278.x","article-title":"The prevalence and distribution of gingival recession in subjects with a high standard of oral hygiene","volume":"21","author":"Serino","year":"1994","journal-title":"J. Clin. Periodontol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/j.1600-051X.2007.01149.x","article-title":"Does tooth brushing influence the development and progression of non-inflammatory gingival recession? A systematic review","volume":"34","author":"Rajapakse","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1902\/annals.1996.1.1.671","article-title":"Mucogingival therapy","volume":"1","year":"1996","journal-title":"Ann. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1902\/jop.2003.74.5.741","article-title":"Evidence-based mucogingival therapy. Part 2: Ordinary and individual patient data meta-analyses of surgical treatment of recession using complete root coverage as the outcome variable","volume":"74","author":"Clauser","year":"2003","journal-title":"J. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1902\/jop.2015.130674","article-title":"Periodontal soft tissue root coverage procedures: A systematic review from the AAP Regeneration Workshop","volume":"86","author":"Chambrone","year":"2015","journal-title":"J Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/prd.12059","article-title":"Periodontal plastic surgery","volume":"68","author":"Zucchelli","year":"2015","journal-title":"Periodontol 2000"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1902\/jop.1956.27.2.92","article-title":"Repair of gingival defects by a sliding flap operation","volume":"27","author":"Grupe","year":"1956","journal-title":"J. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1902\/jop.1968.39.2.65","article-title":"The double papillae repositioned flap in periodontal therapy","volume":"39","author":"Cohen","year":"1968","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1902\/jop.1965.36.4.305","article-title":"Oblique Rotated Flap","volume":"36","author":"Pennel","year":"1965","journal-title":"J. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-051X.1975.tb01721.x","article-title":"Coronally repositioned periodontal flap. Clinical evaluation after one year","volume":"2","author":"Bernimoulin","year":"1975","journal-title":"J Clin. Periodontol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1600-051X.1986.tb01456.x","article-title":"Semilunar coronally repositioned flap","volume":"13","author":"Tarnow","year":"1986","journal-title":"J. Clin. Periodontol."},{"key":"ref_19","first-page":"216","article-title":"Use of the supraperiosteal envelope in soft tissue grafting for root coverage. I. Rationale and technique","volume":"14","author":"Allen","year":"1994","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1600-051X.2006.01039.x","article-title":"Coronally advanced flap: A modified surgical approach for isolated recession-type defects: Three-year results","volume":"34","author":"Zucchelli","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1902\/jop.2000.71.9.1506","article-title":"Treatment of multiple recession-type defects in patients with esthetic demands","volume":"71","author":"Zucchelli","year":"2000","journal-title":"J. Periodontol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/jcpe.12112","article-title":"Treatment of multiple adjacent Miller class I and II gingival recessions with a Modified Coronally Advanced Tunnel (MCAT) technique and a collagen matrix or palatal connective tissue graft: A randomized, controlled clinical trial","volume":"40","author":"Aroca","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.11607\/prd.3680","article-title":"The Laterally Closed Tunnel for the Treatment of Deep Isolated Mandibular Recessions: Surgical Technique and a Report of 24 Cases","volume":"38","author":"Sculean","year":"2018","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/cap.10046","article-title":"Laterally Stretched Flap With Connective Tissue Graft to Treat Single Narrow Deep Recession Defects on Lower Incisors","volume":"9","author":"Carranza","year":"2019","journal-title":"Clin. Adv. Periodontics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1902\/jop.1996.67.11.1216","article-title":"Guided tissue regeneration versus mucogingival surgery in the treatment of human buccal recessions. A 4-year follow-up study","volume":"67","author":"Clauser","year":"1996","journal-title":"J. Periodontol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1902\/jop.2006.050390","article-title":"Root coverage with a coronally positioned flap used in combination with enamel matrix derivative: 18-month clinical evaluation","volume":"77","author":"Pilloni","year":"2006","journal-title":"J. Periodontol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/JPER.19-0350","article-title":"Autogenous soft tissue grafting for periodontal and peri-implant plastic surgical reconstruction","volume":"91","author":"Zucchelli","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1902\/jop.2004.75.3.413","article-title":"Root coverage using the coronally positioned flap with or without a subepithelial connective tissue graft","volume":"75","author":"Joly","year":"2004","journal-title":"J. Periodontol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/prd.12247","article-title":"Experimental and clinical studies on plastic periodontal procedures","volume":"79","author":"Novaes","year":"2019","journal-title":"Periodontology 2000"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.11607\/prd.3581","article-title":"Minimizing Patient Morbidity Following Palatal Gingival Harvesting: A Randomized Controlled Clinical Study","volume":"38","author":"Tavelli","year":"2018","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1902\/jop.2009.090530","article-title":"Acellular dermal matrix seeded with autologous gingival fibroblasts for the treatment of gingival recession: A proof-of-concept study","volume":"81","author":"Jhaveri","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/jre.12199","article-title":"Root coverage by coronally advanced flap with connective tissue graft and\/or enamel matrix derivative: A meta-analysis","volume":"50","author":"Cheng","year":"2015","journal-title":"J. Periodontal Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/1947-2714.112473","article-title":"Hyaluronic Acid: A boon in periodontal therapy","volume":"5","author":"Dahiya","year":"2013","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1524-475X.1999.00079.x","article-title":"Functions of hyaluronan in wound repair","volume":"7","author":"Chen","year":"1999","journal-title":"Wound Repair Regen."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/wrr.12214","article-title":"Hyaluronan in wound healing: Rediscovering a major player","volume":"22","author":"Aya","year":"2014","journal-title":"Wound Repair Regen."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/jre.12602","article-title":"Activity of two hyaluronan preparations on primary human oral fibroblasts","volume":"54","author":"Asparuhova","year":"2019","journal-title":"J. Periodontal Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1034\/j.1600-051X.2003.300203.x","article-title":"Treatment of gingivitis with hyaluronan","volume":"30","author":"Jentsch","year":"2003","journal-title":"J. Clin. Periodontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1902\/jop.2012.120269","article-title":"Hyaluronic Acid as an adjunct after scaling and root planing: A prospective randomized clinical trial","volume":"84","author":"Eick","year":"2013","journal-title":"J. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Pilloni, A., Zeza, B., Kuis, D., Vrazic, D., Domic, T., Olszewska-Czyz, I., Popova, C., Kotsilkov, K., Firkova, E., and Dermendzieva, Y. (2021). Treatment of Residual Periodontal Pockets Using a Hyaluronic Acid-Based Gel: A 12 Month Multicenter Randomized Triple-Blinded Clinical Trial. Antibiotics, 10.","DOI":"10.3390\/antibiotics10080924"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00784-018-2537-4","article-title":"Effectiveness of adjunctive hyaluronic acid application in coronally advanced flap in Miller class I single gingival recession sites: A randomized controlled clinical trial","volume":"23","author":"Pilloni","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/cap.10053","article-title":"Surgical Treatment of a Cemental Tear-Associated Bony Defect Using Hyaluronic Acid and a Resorbable Collagen Membrane: A 2-Year Follow-Up","volume":"9","author":"Pilloni","year":"2019","journal-title":"Clin. Adv. Periodontics"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5095","DOI":"10.1007\/s00784-021-03822-x","article-title":"Healing of intrabony defects following regenerative surgery by means of single-flap approach in conjunction with either hyaluronic acid or an enamel matrix derivative: A 24-month randomized controlled clinical trial","volume":"25","author":"Pilloni","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/pho.2013.3509","article-title":"Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: A randomized clinical study","volume":"32","author":"Romeo","year":"2014","journal-title":"Photomed. Laser Surg."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., and PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref_45","first-page":"8","article-title":"A classification of marginal tissue recession","volume":"5","author":"Miller","year":"1985","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1600-051X.2011.01732.x","article-title":"The interproximal clinical attachment level to classify gingival recessions and predict root coverage outcomes: An explorative and reliability study","volume":"38","author":"Cairo","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Schardt, C., Adams, M.B., Owens, T., Keitz, S., and Fontelo, P. (2007). Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med. Inform. Decis. Mak., 7.","DOI":"10.1186\/1472-6947-7-16"},{"key":"ref_48","first-page":"799","article-title":"Literature search strategies in dental education and research","volume":"16","author":"Khurshid","year":"2021","journal-title":"J. Taibah Univ. Med. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1136\/bmj.38636.593461.68","article-title":"Effectiveness and efficiency of search methods in systematic reviews of complex evidence: Audit of primary sources","volume":"331","author":"Greenhalgh","year":"2005","journal-title":"BMJ"},{"key":"ref_50","unstructured":"Higgins, J., and Green, S. (2022, April 30). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0. Available online: https:\/\/handbook-5-1.cochrane.org."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1016\/j.adaj.2018.08.003","article-title":"Hyaluronic acid used as an adjunct to coronally advanced flap probably results in an increase in recession reduction and root coverage in patients with single Miller class I gingival recessions","volume":"150","year":"2019","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_53","first-page":"113","article-title":"Effects of topical application of hyaluronic acid gel on wound healing following gingival recession treatment","volume":"16","author":"Zukorlic","year":"2011","journal-title":"Eur. J. Med. Res."},{"key":"ref_54","first-page":"94","article-title":"Hyaluronon as an adjunct to coronally advanced flap for the treatment of gingival recession defects","volume":"6","author":"Rajan","year":"2015","journal-title":"Natl. J. Integr. Res. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"746","DOI":"10.4103\/0972-124X.147411","article-title":"Efficacy of hyaluronic acid (hyaluronan) in root coverage procedures as an adjunct to coronally advanced flap in Millers Class I recession: A clinical study","volume":"18","author":"Kumar","year":"2014","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"319","DOI":"10.11607\/prd.2698","article-title":"Coronally Advanced Flap with Different Designs in the Treatment of Gingival Recession: A Comparative Controlled Randomized Clinical Trial","volume":"36","author":"Zucchelli","year":"2016","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"101635","DOI":"10.1016\/j.jebdp.2021.101635","article-title":"Connective Tissue Graft with or without Enamel Matrix Derivative for Treating Gingival Recession Defects: A Systematic Review and Meta-Analysis","volume":"21","author":"Dubey","year":"2021","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41598-017-00113-y","article-title":"Evaluation of Recombinant Human FGF-2 and PDGF-BB in Periodontal Regeneration: A Systematic Review and Meta-Analysis","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1007\/s00784-020-03400-7","article-title":"Use of platelet-rich fibrin for the treatment of gingival recessions: A systematic review and meta-analysis","volume":"24","author":"Miron","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chambrone, L., Botelho, J., Machado, V., Mascarenhas, P., Mendes, J.J., and Avila-Ortiz, G. (2022). Does the subepithelial connective tissue graft in conjunction with a coronally advanced flap remain as the gold standard therapy for the treatment of single gingival recession defects? A systematic review and network meta-analysis. J. Periodontol., ahead of print.","DOI":"10.1002\/JPER.22-0167"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/00016357.2019.1588372","article-title":"Clinical efficacy of xenogeneic collagen matrix in the treatment of gingival recession: A systematic review and meta-analysis","volume":"77","author":"Moraschini","year":"2019","journal-title":"Acta Odontol. Scand."},{"key":"ref_62","first-page":"308","article-title":"Periodontal wound healing\/regeneration of two-wall intrabony defects following reconstructive surgery with cross-linked hyaluronic acid-gel with or without a collagen matrix: A preclinical study in dogs","volume":"52","author":"Shirakata","year":"2021","journal-title":"Quintessence Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/8756-3282(95)80005-B","article-title":"Stimulation of osteoinduction in bone wound healing by high-molecular hyaluronic acid","volume":"16","author":"Sasaki","year":"1995","journal-title":"Bone"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/(SICI)1097-0215(19970410)71:2<251::AID-IJC21>3.0.CO;2-J","article-title":"Early-response gene signalling is induced by angiogenic oligosaccharides of hyaluronan in endothelial cells. Inhibition by non-angiogenic, high-molecular-weight hyaluronan","volume":"71","author":"Deed","year":"1997","journal-title":"Int. J. Cancer"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/10454411940050030601","article-title":"The role of proteoglycans in hard and soft tissue repair","volume":"5","author":"Bertolami","year":"1994","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/JPER.17-0619","article-title":"Long-term evaluation (20 years) of the outcomes of subepithelial connective tissue graft plus coronally advanced flap in the treatment of maxillary single recession-type defects","volume":"89","author":"Franceschi","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1902\/jop.2003.74.8.1110","article-title":"Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative or connective tissue. Part 1: Comparison of clinical parameters","volume":"74","author":"McGuire","year":"2003","journal-title":"J. Periodontol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Snetkov, P., Zakharova, K., Morozkina, S., Olekhnovich, R., and Uspenskaya, M. (2020). Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer. Polymers, 12.","DOI":"10.3390\/polym12081800"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/9\/1539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:34:40Z","timestamp":1760142880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/9\/1539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":69,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["jpm12091539"],"URL":"https:\/\/doi.org\/10.3390\/jpm12091539","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,19]]}}}