{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:31:23Z","timestamp":1762072283489,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Graves\u2019 orbitopathy (GO) is an extrathyroidal manifestation of Graves\u2019 disease (GD), which can be associated with corneal ulcerations or optic neuropathy in severe forms. Transnasal endoscopic orbital decompression (TEOD) is a surgical procedure performed in order to decrease the intraorbital pressure by removing part of its bony borders in cases with excessive mass in orbit. The aim of this study was to present the results and evaluate the efficacy of TEOD for GO. The retrospective study included 28 orbits (16 patients) who underwent TEOD from 2017 to 2020. Outcome was evaluated based on visual acuity improvement, clinical activity score (CAS) decrease, proptosis, and intraocular pressure (IOP) reduction. A preoperative best-corrected visual acuity (BCVA) increased from 0.69 \u00b1 0.385 (mean \u00b1 standard deviation) to 0.74 \u00b1 0.332 (p = 0.17) postoperatively. CAS decreased in 15 orbits postoperatively. Proptosis decreased from 22.89 \u00b1 1.873 mm to 21.25 \u00b1 2.053 mm (p &lt; 0.05). IOP decreased from a preoperative 16.11 \u00b1 3.93 mmHg to 14.40 \u00b1 3.27 mmHg (p &lt; 0.05) postoperatively. In addition, postoperative relief of exposure keratitis was observed. The analysis of development of iatrogenic diplopia revealed increasing in degree of diplopia. TEOD shows rare complications, but significant improvements in BCVA, CAS, proptosis, and IOP.<\/jats:p>","DOI":"10.3390\/jpm12101714","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T02:29:46Z","timestamp":1665973786000},"page":"1714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment Results of Endoscopic Transnasal Orbital Decompression for Graves\u2019 Orbitopathy\u2014A Single-Center Retrospective Analysis in 28 Orbits of 16 Patients"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2538-7064","authenticated-orcid":false,"given":"Krzysztof B.","family":"Po\u015blednik","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1311-8377","authenticated-orcid":false,"given":"Katarzyna","family":"Czerwaty","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5561-2184","authenticated-orcid":false,"given":"Nils","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Moli\u0144ska-Glura","sequence":"additional","affiliation":[{"name":"Department of Economics and Forest Technology, Faculty of Forestry and Wood Technology, Poznan University of Life Sciences, 60-624 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-6705","authenticated-orcid":false,"given":"Anna","family":"Jab\u0142o\u0144ska-Pawlak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9024-9015","authenticated-orcid":false,"given":"Piotr","family":"Mi\u015bkiewicz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Endocrinology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ireneusz","family":"Kantor","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4211-7664","authenticated-orcid":false,"given":"Karolina","family":"D\u017caman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Cyran","sequence":"additional","affiliation":[{"name":"Legorreta Cancer Center, Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-137X","authenticated-orcid":false,"given":"Miros\u0142aw J.","family":"Szczepa\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"},{"name":"Department of Biochemistry, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"ref_1","first-page":"7453260","article-title":"Immunological Aspects of Graves\u2019 Ophthalmopathy","volume":"2019","author":"Nowicka","year":"2019","journal-title":"BioMed Res. 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