{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:42:22Z","timestamp":1760244142603,"version":"build-2065373602"},"reference-count":90,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The ribosomal DNA and pericentromeric satellite repeats are two important types of moderately repeated sequences existing in the human genome. They are functionally involved in the universal stress response. There is accumulating evidence that the copy number variation (CNV) of the repeat units is a novel factor modulating the stress response and, thus, has phenotypic manifestations. The ribosomal repeat copy number plays a role in stress resistance, lifespan, in vitro fertilization chances, disease progression and aging, while the dynamics of the satellite copy number are a sort of indicator of the current stress state. Here, we review some facts showing that a combined assay of rDNA and SatII\/III abundance can provide valuable individual data (\u201cstress profile\u201d) indicating not only the inherited adaptive reserve but also the stress duration and acute or chronic character of the stress. Thus, the repeat count could have applications in personalized medicine in the future.<\/jats:p>","DOI":"10.3390\/jpm12101752","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T04:40:36Z","timestamp":1666586436000},"page":"1752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Assay of rDNA and SatIII Copy Numbers as an Individual Profile of Stress Resistance, Longevity, Fertility and Disease Predisposition"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-6685","authenticated-orcid":false,"given":"Lev N.","family":"Porokhovnik","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, Research Centre for Medical Genetics, 1 Moskvorechye, 115522 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tig.2012.03.002","article-title":"Exploring the role of copy number variants in human adaptation","volume":"28","author":"Iskow","year":"2012","journal-title":"Trends Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1365-2443.2011.01519.x","article-title":"How does genome instability affect lifespan?","volume":"16","author":"Kobayashi","year":"2011","journal-title":"Genes Cells"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1179044","article-title":"Abundance of ribosomal RNA gene copies maintains genome integrity","volume":"327","author":"Ide","year":"2010","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Symonov\u00e1, R. 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