{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:16:53Z","timestamp":1782782213794,"version":"3.54.5"},"reference-count":32,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education","award":["None"],"award-info":[{"award-number":["None"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This study aimed to determine the impact of modifications in emergency department (ED) practices caused by the coronavirus disease 2019 (COVID-19) pandemic on the clinical outcomes and management of patients with septic shock. We performed a retrospective study. Patients with septic shock who presented to the ED between 1 January 2018 and 19 January 2020 were allocated to the pre-COVID-19 group, whereas those who presented between 20 January 2020 and 31 December 2020 were assigned to the post-COVID-19 group. We used propensity score matching to compare the sepsis-related interventions and clinical outcomes. The primary outcome measure was in-hospital mortality. Of the 3697 patients included, 2254 were classified as pre-COVID-19 and 1143 as post-COVID-19. A total of 1140 propensity score-matched pairings were created. Overall, the in-hospital mortality rate was 25.5%, with no statistical difference between the pre- and post-COVID-19 groups (p = 0.92). In a matched cohort, the post-COVID-19 group had delayed lactate measurement, blood culture test, and infection source control (all p &lt; 0.05). There was no significant difference in time to antibiotics (p = 0.19) or vasopressor administration (p = 0.09) between the groups. Although sepsis-related interventions were delayed during the COVID-19 pandemic, there was no significant difference in the in-hospital mortality between the pre- and post-COVID-19 groups.<\/jats:p>","DOI":"10.3390\/jpm12111803","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T06:01:28Z","timestamp":1667282488000},"page":"1803","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of COVID-19 Pandemic on Management and Outcomes in Patients with Septic Shock in the Emergency Department"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-1008","authenticated-orcid":false,"given":"Daun","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1714-1400","authenticated-orcid":false,"given":"Gun Tak","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-990X","authenticated-orcid":false,"given":"Jong Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-1040","authenticated-orcid":false,"given":"Tae Gun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunga","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul 06355, Korea"},{"name":"Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doeun","family":"Jang","sequence":"additional","affiliation":[{"name":"Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-5966","authenticated-orcid":false,"given":"Won Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Hwan","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-011X","authenticated-orcid":false,"given":"Sung Phil","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-257X","authenticated-orcid":false,"given":"Jin Ho","family":"Beom","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-6937","authenticated-orcid":false,"given":"Sung-Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Guro Hospital, Korea University Medical Center, Seoul 08308, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon Yong","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-2217","authenticated-orcid":false,"given":"Gil Joon","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byuk Sung","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-1269","authenticated-orcid":false,"given":"Kap Su","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Korea University Anam Hospital, Seoul 02841, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7121-2137","authenticated-orcid":false,"given":"Jong Hwan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-304X","authenticated-orcid":false,"given":"Hanjin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Korea University College of Medicine, Korea University Ansan Hospital, Ansan 15355, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Korean Shock Society (KoSS) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Yeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/STROKEAHA.120.032789","article-title":"Influence of the COVID-19 Pandemic on Treatment Times for Acute Ischemic Stroke: The Society of Vascular and Interventional Neurology Multicenter Collaboration","volume":"52","author":"Siegler","year":"2021","journal-title":"Stroke"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.15441\/ceem.21.131","article-title":"Discharge from the Emergency Department and Early Hospital Revaluation in Patients with COVID-19 Pneumonia: A Prospective Study","volume":"9","author":"Mattioli","year":"2022","journal-title":"Clin. 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