{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:40:36Z","timestamp":1777470036833,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"College of Health, Medicine and Life Sciences at Brunel University London, UK","award":["P2-06"],"award-info":[{"award-number":["P2-06"]}]},{"name":"Ministry of Higher Education, United Arab Emirates","award":["P2-06"],"award-info":[{"award-number":["P2-06"]}]},{"name":"Saolta University Healthcare Group","award":["P2-06"],"award-info":[{"award-number":["P2-06"]}]},{"name":"Science Foundation Ireland","award":["P2-06"],"award-info":[{"award-number":["P2-06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: A better understanding of the influence of genetic factors on the response to lifestyle interventions in people with obesity may allow the development of more personalised, effective and efficient therapeutic strategies. We sought to determine the influence of six obesity-related genetic risk scores on the magnitude of weight lost by patients with severe obesity who completed a dietary intervention. Methods: In this single-centre prospective cohort study, participants with severe and complicated obesity who completed a 24-week, milk-based meal replacement programme were genotyped to detect the frequency of common risk alleles for obesity and type 2 diabetes-related traits. Genetic risk scores (GRS) for six of these traits were derived. Participants with a potentially deleterious monogenic gene variant were excluded from the analysis. Results: In 93 patients completing the programme who were not carrying a known obesity-related gene mutation, 35.5% had diabetes, 53.8% were female, mean age was 51.4 \u00b1 11 years, mean body mass index was 51.5 \u00b1 8.7 and mean total weight loss percent at 24 weeks was 16 \u00b1 6.3%. The waist\u2013hip ratio (WHR) GRS was inversely associated with percentage total weight loss at 24 weeks (adjusted \u03b2 for one standard deviation increase in WHR GRS \u221211.6 [\u221223.0, \u22120.3], p = 0.045), and patients in the lowest tertile of WHR GRS lost more weight. Conclusions: Patients with severe and complicated obesity with a genetic predisposition to central fat accumulation had less weight loss in a 24-week milk-based meal replacement programme, but there was no evidence for influence from the five other obesity-related genetic risk scores on the response to dietary restriction.<\/jats:p>","DOI":"10.3390\/jpm12111881","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:01:45Z","timestamp":1668045705000},"page":"1881","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher Waist Hip Ratio Genetic Risk Score Is Associated with Reduced Weight Loss in Patients with Severe Obesity Completing a Meal Replacement Programme"],"prefix":"10.3390","volume":"12","author":[{"given":"Dale","family":"Handley","sequence":"first","affiliation":[{"name":"College of Health, Medical and Life Sciences, Brunel University London, London UB8 3PH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Rafey","sequence":"additional","affiliation":[{"name":"Bariatric Medicine Service, Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, H91 YR71 Galway, Ireland"},{"name":"HRB Clinical Research Facility, University of Galway, H91 CF50 Galway, Ireland"},{"name":"Department of Medicine, University of Galway, H91 CF50 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumaya","family":"Almansoori","sequence":"additional","affiliation":[{"name":"College of Health, Medical and Life Sciences, Brunel University London, London UB8 3PH, UK"},{"name":"Faculty of Medicine, Imperial College London, London SW7 2BX, UK"},{"name":"International Centre for Forensic Science, General Department of Forensic Science and Criminology, Dubai Police, Dubai P.O. Box 1493, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Brazil","sequence":"additional","affiliation":[{"name":"Bariatric Medicine Service, Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, H91 YR71 Galway, Ireland"},{"name":"HRB Clinical Research Facility, University of Galway, H91 CF50 Galway, Ireland"},{"name":"Department of Medicine, University of Galway, H91 CF50 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisling","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Bariatric Medicine Service, Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, H91 YR71 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasnat","family":"Amin","sequence":"additional","affiliation":[{"name":"College of Health, Medical and Life Sciences, Brunel University London, London UB8 3PH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"HRB Clinical Research Facility, University of Galway, H91 CF50 Galway, Ireland"},{"name":"Department of Medicine, University of Galway, H91 CF50 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Blakemore","sequence":"additional","affiliation":[{"name":"College of Health, Medical and Life Sciences, Brunel University London, London UB8 3PH, UK"},{"name":"Department of Medicine, University of Galway, H91 CF50 Galway, Ireland"},{"name":"Faculty of Medicine, Imperial College London, London SW7 2BX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5374-7090","authenticated-orcid":false,"given":"Francis","family":"Finucane","sequence":"additional","affiliation":[{"name":"College of Health, Medical and Life Sciences, Brunel University London, London UB8 3PH, UK"},{"name":"Bariatric Medicine Service, Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, H91 YR71 Galway, Ireland"},{"name":"HRB Clinical Research Facility, University of Galway, H91 CF50 Galway, Ireland"},{"name":"Department of Medicine, University of Galway, H91 CF50 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"g6608","DOI":"10.1136\/bmj.g6608","article-title":"Identification, assessment, and management of overweight and obesity: Summary of updated NICE guidance","volume":"349","author":"Stegenga","year":"2014","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1056\/NEJMoa1600869","article-title":"Bariatric Surgery versus Intensive Medical Therapy for Diabetes\u20145-Year Outcomes","volume":"376","author":"Schauer","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1001\/jama.2016.7602","article-title":"Association of Pharmacological Treatments for Obesity with Weight Loss and Adverse Events: A Systematic Review and Meta-analysis","volume":"315","author":"Khera","year":"2016","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0140-6736(06)69701-8","article-title":"Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: Follow-up of the Finnish Diabetes Prevention Study","volume":"368","author":"Lindstrom","year":"2006","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.7326\/0003-4819-143-9-200511010-00010","article-title":"Meta-analysis: Secondary prevention programs for patients with coronary artery disease","volume":"143","author":"Clark","year":"2005","journal-title":"Ann. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJMoa1212914","article-title":"Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes","volume":"369","author":"Wing","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.jada.2007.07.017","article-title":"Weight-loss outcomes: A systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up","volume":"107","author":"Franz","year":"2007","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S2213-8587(16)30162-0","article-title":"Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: A post-hoc analysis of the Look AHEAD randomised clinical trial","volume":"4","author":"Gregg","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Brazil, J.F., Gibson, I., Dunne, D., Hynes, L.B., Harris, A., Bakir, M., Keegan, D., McGuire, B., Hynes, M., and Collins, C. (2021). Improved Quality of Life, Fitness, Mental Health and Cardiovascular Risk Factors with a Publicly Funded Bariatric Lifestyle Intervention for Adults with Severe Obesity: A Prospective Cohort Study. Nutrients, 13.","DOI":"10.3390\/nu13114172"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1126\/science.1104346","article-title":"Genetic factors in type 2 diabetes: The end of the beginning?","volume":"307","author":"Barroso","year":"2005","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1210\/jc.2004-2001","article-title":"Ethnic differences in insulin resistance and body composition in United Kingdom adolescents","volume":"90","author":"Ehtisham","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s001250051132","article-title":"Concordance rate for type II diabetes mellitus in monozygotic twins: Actuarial analysis","volume":"42","author":"Medici","year":"1999","journal-title":"Diabetologia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00125-013-2859-3","article-title":"Shared genetic influence of BMI physical activity and type 2 diabetes: A twin study","volume":"56","author":"Carlsson","year":"2013","journal-title":"Diabetologia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/s41366-022-01172-6","article-title":"The heritability of BMI varies across the range of BMI-a heritability curve analysis in a twin cohort","volume":"46","author":"Azzolini","year":"2022","journal-title":"Int. J. Obes."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.2337\/diacare.26.7.2126","article-title":"Reduced skeletal muscle oxygen uptake and reduced beta-cell function: Two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes","volume":"26","author":"Thamer","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMoa031314","article-title":"Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes","volume":"350","author":"Petersen","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.2337\/diacare.27.8.2033","article-title":"Inflammation, insulin resistance, and adiposity: A study of first-degree relatives of type 2 diabetic subjects","volume":"27","author":"Kriketos","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s00125-006-0285-5","article-title":"Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes","volume":"49","author":"Singh","year":"2006","journal-title":"Diabetologia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrendo.2013.227","article-title":"The bigger picture of FTO: The first GWAS-identified obesity gene","volume":"10","author":"Loos","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"Frayling","year":"2007","journal-title":"Science"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ng.686","article-title":"Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index","volume":"42","author":"Speliotes","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1007\/s00125-014-3270-4","article-title":"Genetic susceptibility to type 2 diabetes and obesity: From genome-wide association studies to rare variants and beyond","volume":"57","author":"Grarup","year":"2014","journal-title":"Diabetologia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/sj.ijo.0803499","article-title":"Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation","volume":"31","author":"Jocken","year":"2007","journal-title":"Int. J. Obes."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.2337\/diabetes.54.7.2251","article-title":"Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: The HERITAGE Family Study","volume":"54","author":"Santoro","year":"2005","journal-title":"Diabetes"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.2337\/diabetes.51.8.2581","article-title":"Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study","volume":"51","author":"Lindi","year":"2002","journal-title":"Diabetes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1056\/NEJMoa062418","article-title":"TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program","volume":"355","author":"Florez","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1758-8111.2011.00006.x","article-title":"Comparison of a low-energy diet and a very low-energy diet in sedentary obese individuals: A pragmatic randomized controlled trial","volume":"1","author":"Christensen","year":"2011","journal-title":"Clin. Obes."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1001\/jama.2010.1505","article-title":"Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: A randomized trial","volume":"304","author":"Goodpaster","year":"2010","journal-title":"JAMA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"b4609","DOI":"10.1136\/bmj.b4609","article-title":"Effect of a very low energy diet on moderate and severe obstructive sleep apnoea in obese men: A randomised controlled trial","volume":"339","author":"Johansson","year":"2009","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/archinternmed.2009.508","article-title":"Nonsurgical weight loss for extreme obesity in primary care settings: Results of the Louisiana Obese Subjects Study","volume":"170","author":"Ryan","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2147\/DMSO.S226327","article-title":"Effects of a Milk-Based Meal Replacement Program on Weight and Metabolic Characteristics in Adults with Severe Obesity","volume":"13","author":"Rafey","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"335","author":"Altman","year":"2007","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"736390","DOI":"10.3389\/fgene.2021.736390","article-title":"A Novel Quality-Control Procedure to Improve the Accuracy of Rare Variant Calling in SNP Arrays","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"D886","DOI":"10.1093\/nar\/gky1016","article-title":"CADD: Predicting the deleteriousness of variants throughout the human genome","volume":"47","author":"Rentzsch","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic studies of body mass index yield new insights for obesity biology","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10495","DOI":"10.1038\/ncomms10495","article-title":"New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk","volume":"7","author":"Lu","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.2337\/db15-1671","article-title":"Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease","volume":"65","author":"Yaghootkar","year":"2016","journal-title":"Diabetes"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41588-018-0334-2","article-title":"Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution","volume":"51","author":"Justice","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Dastani, Z., Hivert, M.-F., Timpson, N., Perry, J.R.B., Yuan, X., Scott, R.A., Henneman, P., Heid, I.M., Kizer, J.R., and Lyytik\u00e4inen, L.-P. (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet., 8.","DOI":"10.1371\/journal.pgen.1002607"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.2337\/db16-1253","article-title":"An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans","volume":"66","author":"Scott","year":"2017","journal-title":"Diabetes"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"s13742-015","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Magi, R., Manning, S., Yousseif, A., Pucci, A., Santini, F., Karra, E., Querci, G., Pelosini, C., McCarthy, M.I., and Lindgren, C.M. (2013). Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0070735"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.soard.2016.04.016","article-title":"The FKBP5 polymorphism rs1360780 is associated with lower weight loss after bariatric surgery: 26 months of follow-up","volume":"12","author":"Hartmann","year":"2016","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.clnu.2017.05.018","article-title":"The polymorphism rs17782313 near MC4R gene is related with anthropometric changes in women submitted to bariatric surgery over 60 months","volume":"37","author":"Resende","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.nut.2015.05.020","article-title":"A single FTO gene variant rs9939609 is associated with body weight evolution in a multiethnic extremely obese population that underwent bariatric surgery","volume":"31","author":"Rodrigues","year":"2015","journal-title":"Nutrition"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s11695-019-04184-w","article-title":"Genetic Obesity and Bariatric Surgery Outcome in 1014 Patients with Morbid Obesity","volume":"30","author":"Cooiman","year":"2020","journal-title":"Obes. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/ajcn\/nqab303","article-title":"Genetic risk for obesity and the effectiveness of the ChooseWell 365 workplace intervention to prevent weight gain and improve dietary choices","volume":"115","author":"Dashti","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2337\/db21-0741","article-title":"Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention: The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention","volume":"71","author":"McCaffery","year":"2022","journal-title":"Diabetes"},{"key":"ref_49","first-page":"17","article-title":"Polygenic risk score for predicting weight loss after bariatric surgery","volume":"3","author":"Tchernof","year":"2018","journal-title":"JCI Insight"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ciudin, A., Fidilio, E., Guti\u00e9rrez-Carrasquilla, L., Caix\u00e0s, A., Vilarrasa, N., Pellitero, S., Sim\u00f3-Servat, A., Vilallonga, R., Ruiz, A., and de la Fuente, M. (2021). A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study. J. Pers. Med., 11.","DOI":"10.3390\/jpm11101040"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/11\/1881\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:13:32Z","timestamp":1760145212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/11\/1881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["jpm12111881"],"URL":"https:\/\/doi.org\/10.3390\/jpm12111881","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,9]]}}}