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Neurologists find it sometimes difficult to apply these guidelines, having to confront situations such as (1) ischemic strokes, mainly cardioembolic ones, in patients with already low LDL-cholesterol levels; (2) myasthenic patients, whose lifespan has been extended by available treatment, and whose age and cholesterol levels put them at risk for ischemic stroke; (3) patients with myotonic dystrophy, whose disease often associates diabetes mellitus and heart conduction defects, and in whom blood cholesterol management is also not settled. As such, further trials are needed to address these issues.<\/jats:p>","DOI":"10.3390\/jpm12121981","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T08:46:41Z","timestamp":1669798001000},"page":"1981","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cholesterol Management in Neurology: Time for Revised Strategies?"],"prefix":"10.3390","volume":"12","author":[{"given":"Felicia Liana","family":"Andronie-Cioar\u0103","sequence":"first","affiliation":[{"name":"Department of Psycho-Neuroscience and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-2877","authenticated-orcid":false,"given":"Anamaria","family":"Jurc\u0103u","sequence":"additional","affiliation":[{"name":"Department of Psycho-Neuroscience and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carolina","family":"Jurc\u0103u","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-7180","authenticated-orcid":false,"given":"Delia Carmen","family":"Nistor-Cseppent\u00f6","sequence":"additional","affiliation":[{"name":"Department of Psycho-Neuroscience and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurel","family":"Simion","sequence":"additional","affiliation":[{"name":"Department of Psycho-Neuroscience and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.7164\/antibiotics.29.1346","article-title":"ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by penicillium citrinium","volume":"29","author":"Endo","year":"1976","journal-title":"J. Antiobiot."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Scandinavian Simvastatin Survival Study Group (1994). Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet, 344, 1383\u20131389.","DOI":"10.1016\/S0140-6736(94)90566-5"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1161\/01.CIR.92.9.2419","article-title":"Reduction in cardiovascular events during pravastatin therapy. Pooled analysis of clinical events of the Pravastatin Atherosclerosis Intervention Program","volume":"92","author":"Byington","year":"1995","journal-title":"Circulation"},{"key":"ref_4","first-page":"e1082","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA Guideline on the management of blood cholesterol: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"139","author":"Grundy","year":"2019","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/STROKEAHA.119.028718","article-title":"Treat Stroke to Target Investigators. Benefit of targeting a LDL (low-density lipoprotein) cholesterol <70 mg\/dL during 5 years after ischemic stroke","volume":"51","author":"Amarenco","year":"2020","journal-title":"Stroke"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Turner, R.M., and Pirmohamed, M. (2020). Statin-related myotoxicity: A comprehensive review of pharmacokinetic, pharmacogenomic and muscle components. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010022"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1161\/CIRCULATIONAHA.117.030950","article-title":"Benefit of adding ezetimibe to statin therapy on cardiovascular outcomes and and safety in patients with versus without diabetes mellitus","volume":"137","author":"Giugliano","year":"2017","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1615664","article-title":"Evolocumab and clinical outcomes in patients with cardiovascular disease","volume":"376","author":"Sabatine","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ceb.2018.06.002","article-title":"Mechanisms of cellular cholesterol compartmentalization: Recent insights","volume":"53","author":"Ikonen","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature04399","article-title":"Role of cholesterol and lipid organization in disease","volume":"438","author":"Maxfield","year":"2005","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"105215","DOI":"10.1016\/j.phrs.2020.105215","article-title":"Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues","volume":"163","author":"Gliozzi","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12013-017-0792-7","article-title":"High cholesterol\/low cholesterol: Effects in biological membranes: A review","volume":"75","author":"Subczynski","year":"2017","journal-title":"Cell Biochem. Biophys."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fphys.2016.00360","article-title":"Molecular properties of globin channels and pores: Role of cholesterol in ligand binding and movement","volume":"7","author":"Morrill","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21896","DOI":"10.1073\/pnas.2004807117","article-title":"How cholesterol stiffens unsaturated lipid membranes","volume":"117","author":"Chakraborty","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.bbamem.2018.05.002","article-title":"Dynamic pattern generation in cell membranes: Current insights into membrane organization","volume":"1860","author":"Raghunathan","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Paukner, K., Kr\u00e1lov\u00e1 Lesn\u00e1, I., and Poledne, R. (2022). Cholesterol in the cell membrane-an emerging player in atherogenesis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23010533"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1194\/jlr.TR119000383","article-title":"The ins and outs of lipid rafts: Functions in intracellular cholesterol homeostasis, microparticles, and cell membranes: Thematic Review Series: Biology of Lipid Rafts","volume":"61","author":"Ouweneel","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"109413","DOI":"10.1016\/j.abb.2022.109413","article-title":"Membrane lipid organization and nicotinic acetylcholine receptor function: A two-way physiological relationship","volume":"730","author":"Fabiani","year":"2022","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.tins.2022.01.001","article-title":"Local cholesterol metabolism orchestrates remyelination","volume":"45","author":"Berghoff","year":"2022","journal-title":"Trends Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Poitelon, Y., Kopec, A.M., and Belin, S. (2020). Myelin fat facts: An overview of lipids and fatty acid metabolism. Cells, 9.","DOI":"10.3390\/cells9040812"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s11095-021-03098-6","article-title":"Interactions of lipids, lipoproteins, and apolipoproteins with the blood-brain barrier","volume":"38","author":"Rhea","year":"2021","journal-title":"Pharm. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"134532","DOI":"10.1016\/j.neulet.2019.134532","article-title":"Astrocytes in myelination and remyelination","volume":"713","author":"Miron","year":"2019","journal-title":"Neurosci. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"108966","DOI":"10.1016\/j.abb.2021.108966","article-title":"An overview of the synaptic vesicle lipid composition","volume":"709","author":"Binotti","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Geda, O., T\u00e1bi, T., Lakatos, P.P., and Sz\u00f6k\u0151, \u00c9. (2022). Differential ganglioside and cholesterol depletion by various cyclodextrin derivatives and their effect on synaptosomal glutamate release. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169460"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neulet.2006.06.029","article-title":"Influence of cholesterol depletion in plasma membrane of rat synaptosomes on calcium-dependent and calcium-independent exocytosis","volume":"405","author":"Waseem","year":"2006","journal-title":"Neurosci. Lett."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1523\/JNEUROSCI.1352-11.2012","article-title":"Critical time window of neuronal cholesterol synthesis during neurite outgrowth","volume":"32","author":"Funfschilling","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.plipres.2011.06.002","article-title":"Cholesterol metabolism in neurons and astrocytes","volume":"50","author":"Pfrieger","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.294.5545.1354","article-title":"CNS synaptogenesis promoted by glia-derived cholesterol","volume":"294","author":"Mauch","year":"2001","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/hipo.20743","article-title":"Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers","volume":"20","author":"Valdez","year":"2010","journal-title":"Hippocampus"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.yexcr.2017.02.034","article-title":"The mevalonate pathway in neurons: It\u2019s not just about cholesterol","volume":"360","author":"Moutinho","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0898-6568(97)00120-4","article-title":"Membrane association and targeting of prenylated Ras-like GTPases","volume":"10","author":"Seabra","year":"1998","journal-title":"Cell. Signal."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1256405","article-title":"The role of the Rho GTPases in neuronal development","volume":"19","author":"Govek","year":"2005","journal-title":"Genes Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1471-4159.2008.05854.x","article-title":"Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation","volume":"108","author":"Kim","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1146\/annurev.biochem.78.072407.103859","article-title":"Cholesterol 24- hydroxylase: An enzyme of cholesterol turnover in the brain","volume":"78","author":"Russell","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archneur.60.4.510","article-title":"Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease","volume":"60","author":"Vega","year":"2003","journal-title":"Arch. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"26383","DOI":"10.1074\/jbc.M115.664367","article-title":"Effect of cholesterol reduction on receptor signaling in neurons","volume":"290","author":"Fukui","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11974","DOI":"10.1038\/s41598-018-30384-y","article-title":"Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability","volume":"8","author":"Mosqueira","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00232-019-00079-0","article-title":"Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes","volume":"252","author":"Woods","year":"2019","journal-title":"J. Membr. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00232-022-00239-9","article-title":"Fluorescence studies of nicotinic acetylcholine receptor and its associated lipid milieu: The influence of Erwin London\u2019s methodological approaches","volume":"255","author":"Barrantes","year":"2022","journal-title":"J. Membr. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Krivoi, I.I., and Petrov, A.M. (2019). Cholesterol and the safety factor for neuromuscular transmission. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051046"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"17122","DOI":"10.1074\/jbc.M110.211870","article-title":"Cholesterol modulates the rate and mechanism of acetylcholine receptor internalization","volume":"286","author":"Borroni","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/eurheartj\/ehy680","article-title":"Effect of statins on measures of coagulation: Potential role of low-density lipoprotein receptors","volume":"40","author":"Paciullo","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_43","first-page":"463","article-title":"Significant reduction in the LDL cholesterol increases the risk of intracerebral hemorrhage: A systematic review and meta-analysis of 33 randomized controlled trials","volume":"12","author":"Cheng","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00392-017-1106-1","article-title":"HDL cholesterol: Reappraisal of its clinical relevance","volume":"106","author":"Kleber","year":"2017","journal-title":"Clin. Res. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Gorabi, A.M., Kiaie, N., Hajighasemi, S., Banach, M., Penson, P.E., Jamialahmadi, T., and Sahebkar, A. (2019). Statin-induced nitric oxide signaling: Mechanisms and therapeutic implications. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122051"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic effects of statins on the cardiovascular system","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCGENETICS.113.000099","article-title":"Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentration in routine clinical care","volume":"6","author":"DeGorter","year":"2013","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/14740338.2020.1747431","article-title":"An overview of statin-induced myopathy and perspectives for the future","volume":"19","author":"Nikolic","year":"2020","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jbspin.2019.01.018","article-title":"Statins, myalgia, and rhabdomyolysis","volume":"87","author":"Tournadre","year":"2020","journal-title":"Jt. Bone Spine"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1080\/00325481.2017.1292107","article-title":"New onset diabetes mellitus induced by statins: Current evidence","volume":"129","author":"Chrysant","year":"2017","journal-title":"Postgrad. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/jcsm.12654","article-title":"Effects of statins on mitochondrial pathways","volume":"12","author":"Mollazadeh","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1016\/j.jacc.2019.09.041","article-title":"Effects of statins on memory, cognition, and brain volume in the elderly","volume":"74","author":"Samaras","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41569-018-0098-5","article-title":"Safety and efficacy of statin therapy","volume":"15","author":"Adhyaru","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jacl.2012.03.003","article-title":"Understanding Statin use in America and Gaps in Patient Education (USAGE): An internet-based survey of 10,138 current and former statin users","volume":"6","author":"Cohen","year":"2012","journal-title":"J. Clin. Lipidol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"39982","DOI":"10.1038\/srep39982","article-title":"Association between reductions in low-density lipoprotein cholesterol with statin therapy and the risk of new-onset diabetes: A meta-analysis","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Galicia-Garcia, U., Jebari, S., Larrea-Sebal, A., Uribe, K.B., Siddiqi, H., Ostolaza, H., Benito-Vicente, A., and Mart\u00edn, C. (2020). Statin treatment-induced development of type 2 diabetes: From clinical evidence to mechanistic insights. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134725"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40035-018-0110-3","article-title":"The role of statins in both cognitive impairment and protection against dementia: A tale of two mechanisms","volume":"7","author":"Schultz","year":"2018","journal-title":"Transl. Neurodegener."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/1871527319666200303121016","article-title":"Oxidative stress in the pathogenesis of Alzheimer\u2019s disease and cerebrovascular disease with therapeutic implications","volume":"19","author":"Jurcau","year":"2020","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jacl.2019.04.011","article-title":"The Statin Adverse Treatment Experience Survey: Experience of patients reporting side effects of statin therapy","volume":"13","author":"Jacobson","year":"2019","journal-title":"J. Clin. Lipidol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/clpt.2014.121","article-title":"Phenotype standardization for statin-induced myotoxicity","volume":"96","author":"Alfirevic","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_61","first-page":"205","article-title":"Withdrawal of cerivastatin from the world market","volume":"2","author":"Furberg","year":"2001","journal-title":"Curr. Control Trials Cardiovasc. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00228-014-1801-z","article-title":"Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: A class effect?","volume":"71","author":"Birmingham","year":"2015","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/gim.2016.33","article-title":"Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response","volume":"19","author":"Kozyra","year":"2017","journal-title":"Genet. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/14740338.2018.1394455","article-title":"Statin drug interactions and related adverse reactions: An update","volume":"17","author":"Bellosta","year":"2018","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/CIRCRESAHA.118.312782","article-title":"Statin toxicity","volume":"124","author":"Ward","year":"2019","journal-title":"Circ. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2015.08.002","article-title":"Statin-induced myopathy is associated with mitochondrial complex III inhibition","volume":"22","author":"Schirris","year":"2015","journal-title":"Cell Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.freeradbiomed.2011.10.449","article-title":"Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes","volume":"52","author":"Kwak","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1016\/j.xphs.2017.04.005","article-title":"Association of miR-145 with statin-induced skeletal muscle toxicity in human rhabdomyosarcoma RD Cells","volume":"106","author":"Saito","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jacbts.2019.03.012","article-title":"A mechanism for statin-induced susceptibility to myopathy","volume":"4","author":"Lotteau","year":"2019","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Jurcau, A. (2021). Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111847"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/path.2018","article-title":"Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia","volume":"210","author":"Draeger","year":"2006","journal-title":"J. Pathol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jacl.2015.08.006","article-title":"ODYSSEY ALTERNATIVE Investigators. Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial","volume":"9","author":"Moriarty","year":"2015","journal-title":"J. Clin. Lipidol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/1744666X.2018.1440206","article-title":"Statin-induced myalgia and myositis: An update on pathogenesis and clinical recommendations","volume":"14","author":"Milisenda","year":"2018","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMra1515161","article-title":"Statin-associated autoimmune myopathy","volume":"374","author":"Mammen","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/WCO.0000000000000606","article-title":"Toxic myopathies","volume":"31","author":"Pasnoor","year":"2018","journal-title":"Curr. Opin. Neurol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.immuni.2016.01.009","article-title":"Poor repair of skeletal muscle in aging mice reflects a defect in local interleukin-33-dependent accumulation of regulatory T cells","volume":"44","author":"Kuswanto","year":"2016","journal-title":"Immunity"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12974-019-1587-0","article-title":"Exosomes derived from statin-modified bone marrow dendritic cells increase thymus-derived natural regulatory T cells in experimental autoimmune myasthenia gravis","volume":"16","author":"Zhang","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1001\/archinte.164.2.153","article-title":"Conceptual foundations of the UCSD statin study","volume":"164","author":"Golomb","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12944-019-0965-z","article-title":"Role of cholesterol and sphingolipids in brain development and neurological diseases","volume":"18","author":"Hussain","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"14241","DOI":"10.1038\/ncomms14241","article-title":"Dietary cholesterol promotes repair of demyelinated lesions in the adult brain","volume":"8","author":"Berghoff","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"13609","DOI":"10.1523\/JNEUROSCI.2765-08.2008","article-title":"Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo","volume":"28","author":"Klopfleisch","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.2353\/ajpath.2009.080947","article-title":"Statin therapy inhibits remyelination in the central nervous system","volume":"174","author":"Miron","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"680301","DOI":"10.3389\/fcell.2021.680301","article-title":"Astrocyte-neuron signaling in synaptogenesis","volume":"9","author":"Shan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-pharmtox-010919-023411","article-title":"Lipid-dependent regulation of ion channels and G protein-coupled receptors: Insights from structures and simulations","volume":"60","author":"Duncan","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.chemphyslip.2016.04.006","article-title":"Interaction of G protein coupled receptors and cholesterol","volume":"199","author":"Gimpl","year":"2016","journal-title":"Chem. Phys. Lipids"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"S561","DOI":"10.1016\/j.jalz.2010.05.1915","article-title":"Effects of chronic and acute simvastatin on neuronal excitability and LTP in APPswe\/PS1dE9 mice","volume":"6","author":"Herron","year":"2010","journal-title":"Alzheimers Dement."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1194\/jlr.M081240","article-title":"Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels","volume":"60","author":"Bukiya","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/biof.5520180212","article-title":"The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications","volume":"18","author":"Langsjoen","year":"2003","journal-title":"Biofactors"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.2147\/DDDT.S223153","article-title":"Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: A double-blind, randomized, placebo-controlled study","volume":"13","author":"Derosa","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/eurheartj\/ehr224","article-title":"Opposite effects of statins on mitochondria of cardiac and skeletal muscles: A \u2018mitohormesis\u2019 mechanism involving reactive oxygen species and PGC-1","volume":"33","author":"Bouitbir","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jacc.2013.02.074","article-title":"Simvastatin impairs exercise training adaptations","volume":"62","author":"Mikus","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"104201","DOI":"10.1016\/j.phrs.2019.03.010","article-title":"Mechanisms of statin-associated skeletal muscle-associated symptoms","volume":"154","author":"Bouitbir","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jns.2012.12.023","article-title":"Decreased skeletal muscle mitochondrial DNA in patients with statin-induced myopathy","volume":"325","author":"Stringer","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"727","DOI":"10.31083\/j.jin2003078","article-title":"Molecular pathophysiological mechanisms of ischemia\/reperfusion injuries after recanalization therapy for acute ischemic stroke","volume":"20","author":"Jurcau","year":"2021","journal-title":"J. Integr. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cmet.2015.05.022","article-title":"HMG-CoA reductase inhibitors bind to PPARalpha to upregulate neurotrophin expression in the brain and improve memory in mice","volume":"22","author":"Roy","year":"2015","journal-title":"Cell Metab."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainresbull.2020.09.019","article-title":"High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin","volume":"165","author":"Okudan","year":"2020","journal-title":"Brain Res. Bull."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/17512433.2019.1606711","article-title":"Evidence and mechanisms for statin-induced cognitive decline","volume":"12","author":"Tan","year":"2019","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"114349","DOI":"10.1016\/j.bcp.2020.114349","article-title":"Serotonin transporter regulation by cholesterol-independent lipid signaling","volume":"183","author":"Deveau","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1136\/jnnp-2013-306573.211","article-title":"Statins can cause myasthenia gravis: Fact or fiction?","volume":"84","author":"Virgo","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_100","first-page":"3","article-title":"The epidemiology of neuromuscular disorders: A comprehensive overview of the literature","volume":"2","author":"Deenen","year":"2015","journal-title":"J. Neuromuscul. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.nmd.2020.08.355","article-title":"Mortality rates and causes of death in Swedish myasthenia gravis patients","volume":"30","author":"Westerberg","year":"2020","journal-title":"Neuromuscul. Disord."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/mus.26132","article-title":"Survival and mortality of adult-onset myasthenia gravis in the population of Belgrade, Serbia","volume":"58","author":"Basta","year":"2018","journal-title":"Muscle Nerve"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Sheikh, S., Alvi, U., Soliven, B., and Rezania, K. (2021). Drugs that induce or cause deterioration of myasthenia gravis: An update. J. Clin. Med., 10.","DOI":"10.3390\/jcm10071537"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jocn.2013.11.009","article-title":"Statins can induce myasthenia gravis","volume":"21","author":"Gale","year":"2014","journal-title":"J. Clin. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11910-020-01064-0","article-title":"Neuromuscular complications of statin therapy","volume":"20","author":"Crisan","year":"2020","journal-title":"Curr. Neurol. Neurosci Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/01.md.0000209337.59874.aa","article-title":"Statin-associated myasthenia gravis: Report of 4 cases and review of the literature","volume":"85","author":"Purvin","year":"2006","journal-title":"Medicine"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.therap.2019.07.004","article-title":"Statin-associated myasthenia: A case report and literature review","volume":"75","author":"Masmoudi","year":"2020","journal-title":"Therapies"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/mus.26637","article-title":"Statin-induced myasthenia: A disproportionality analysis of the WHO\u2019s VigiBase pharmacovigilance database","volume":"60","author":"Batteux","year":"2019","journal-title":"Muscle Nerve"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Attardo, S., Musumeci, O., Velardo, D., and Toscano, A. (2022). Statins neuromuscular adverse effects. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158364"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1196\/annals.1254.032","article-title":"T cells and cytokines in the pathogenesis of acquired myasthenia gravis","volume":"998","author":"Milani","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature01158","article-title":"The HMG-CoA reductase inhibitor atorvastatin promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease","volume":"420","author":"Youssef","year":"2002","journal-title":"Nature"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jacl.2014.12.005","article-title":"Use of lipid-lowering medications in myasthenia gravis: A case report and literature review","volume":"9","author":"Ragbourne","year":"2015","journal-title":"J. Clin. Lipidol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"456348","DOI":"10.1155\/2015\/456348","article-title":"Muscular dystrophy: Disease mechanisms and therapies","volume":"2015","author":"Pandey","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1542\/peds.2018-0333L","article-title":"Psychosocial management of the patient with Duchenne muscular dystrophy","volume":"142","author":"Colvin","year":"2018","journal-title":"Pediatrics"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13023-020-01430-8","article-title":"Global epidemiology of Duchenne muscular dystrophy: An updated systematic review and meta-analysis","volume":"15","author":"Crisafulli","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13023-017-0631-3","article-title":"The burden, epidemiology, costs and treatment for Duchenne muscular dystrophy: An evidence review","volume":"12","author":"Ryder","year":"2017","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mus.20301","article-title":"Clinical and molecular aspects of the myotonic dystrophies: A review","volume":"32","author":"Brook","year":"2005","journal-title":"Muscle Nerve"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.tcm.2019.06.001","article-title":"Cardiovascular manifestations of myotonic dystrophy","volume":"30","author":"Wahbi","year":"2020","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jacl.2017.08.014","article-title":"Successful treatment of a patient with statin-induced myopathy and myotonic dystrophy type II with proprotein convertase subtilisin\/kexin type 9 inhibitor, alirocumab (Praluent)","volume":"11","author":"Shakir","year":"2017","journal-title":"J. Clin. Lipidol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"fcaa191","DOI":"10.1093\/braincomms\/fcaa191","article-title":"Diagnostic modelling and therapeutic monitoring of immune-mediated necrotizing myopathy: Role of electrical myotonia","volume":"2","author":"Triplett","year":"2020","journal-title":"Brain Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00131402-200103000-00003","article-title":"HMG-CoA reductase inhibitor myopathy: Clinical, electrophysiological, and pathologic data in five patients","volume":"2","author":"Meriggioli","year":"2001","journal-title":"J. Clin. Neuromuscul. Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1590\/S0004-282X2008000600024","article-title":"Myotonic potentials in statin-induced rhabdomyolysis","volume":"66","author":"Lissa","year":"2008","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fphar.2017.00500","article-title":"Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study","volume":"8","author":"Camerino","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.ajpath.2014.04.013","article-title":"Abnormal splicing of NEDD4 in myotonic dystrophy type 2: Possible link to statin adverse reactions","volume":"184","author":"Screen","year":"2014","journal-title":"Am. J. Pathol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1161\/10.1161\/01.ATV.0000194548.11901.a4","article-title":"Mechanisms of statin-induced myopathy: A role for the ubiquitin-proteasome pathway?","volume":"25","author":"Chapman","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cell.2006.11.039","article-title":"NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN","volume":"128","author":"Wang","year":"2007","journal-title":"Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"bcr2013203094","DOI":"10.1136\/bcr-2013-203094","article-title":"Persisting weakness after withdrawal of a statin","volume":"2014","author":"Mygland","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2147\/TCRM.S162931","article-title":"Myopathy due to HMGCR antibodies in adult mimicking muscular dystrophy associated with cancer and statin exposure-narrative review of the literature-case report","volume":"14","author":"Carvalho","year":"2018","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"478","DOI":"10.7326\/0003-4819-152-7-201004060-00025","article-title":"Another side to statin-related side effects","volume":"152","author":"Knoblauch","year":"2010","journal-title":"Ann. Int. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e523","DOI":"10.1212\/NXI.0000000000000523","article-title":"Anti-HMGCR myopathy may resemble limb-girdle muscular dystrophy","volume":"6","author":"Mohassel","year":"2018","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.atherosclerosis.2011.07.007","article-title":"Mechanisms of statin-induced myalgia assessed by physiogenomic associations","volume":"218","author":"Windemuth","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1080\/14740338.2020.1796966","article-title":"Statin use and safety concerns: An overview of the past, present, and the future","volume":"19","author":"Mulchandani","year":"2020","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1000141","DOI":"10.4172\/2329-6887.1000141","article-title":"Examination of the FDA warning for statins and cognitive dysfunction","volume":"2","author":"Sahebzamani","year":"2014","journal-title":"J. Pharmacovigil."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"638","DOI":"10.14740\/jocmr3066w","article-title":"Association of cognitive impairment in patients on 3-Hydroxy-3-Methyl-Glutaryl-CoA reductase inhibitors","volume":"9","author":"Roy","year":"2017","journal-title":"J. Clin. Med. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/07853890.2020.1800074","article-title":"Personalised medicine in hypercholesterolaemia: The role of pharmacogenetics in statin therapy","volume":"52","author":"Ahangari","year":"2020","journal-title":"Ann. Med."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Barthold, D., Joyce, G., Brinton, R.D., Wharton, W., Kehoe, P.G., and Zissimopoulos, J. (2020). Association of combination statin and antihypertensive therapy with reduced Alzheimer\u2019s disease and related dementia risk. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0229541"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JAD-215735","article-title":"Pharmacogenetic analyses of therapeutic effects of lipophilic statins on cognitive and functional changes in Alzheimer\u2019s disease","volume":"87","author":"Bertolucci","year":"2022","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"968039","DOI":"10.3389\/fnagi.2022.968039","article-title":"Statins and cognition: Modifying factors and possible underlying mechanisms","volume":"14","author":"Kashanian","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1345\/aph.1Q620","article-title":"Is statin-associated cognitive impairment clinically relevant? A narrative review and clinical recommendations","volume":"46","author":"Cameron","year":"2012","journal-title":"Ann. Pharmacother."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Kim, M.-Y., Jung, M., Noh, Y., Shin, S., Hong, C.H., Lee, S., and Jung, Y.-S. (2020). Impact of statin use on dementia incidence in elderly men and women with ischemic heart disease. Biomedicines, 8.","DOI":"10.3390\/biomedicines8020030"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1097\/GME.0000000000001412","article-title":"Statin therapy: Does sex matter?","volume":"26","author":"Faubion","year":"2019","journal-title":"Menopause"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.52711\/0974-360X.2021.00650","article-title":"Repurposing statins as a potential ligand for estrogen receptor alpha via molecular docking","volume":"14","author":"Alisha","year":"2021","journal-title":"Res. J. Pharm. Tech."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Joosten, H., Visser, S.T., van Eersel, M.E., Gansevoort, R.T., Bilo, H.J., Slaets, J.P., and Izaks, G.J. (2014). Statin use and cognitive function: Population-based observational study with long-term follow-up. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0115755"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.mayocp.2013.07.013","article-title":"Statins and cognition: A systematic review and meta-analysis of short- and long-term cognitive effects","volume":"88","author":"Swiger","year":"2013","journal-title":"Mayo Clin. Proc."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.122.319951","article-title":"Post-stroke cognitive impairment and dementia","volume":"130","author":"Rost","year":"2022","journal-title":"Circ. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/jgs.16342","article-title":"Benefits and harms of statins in people with dementia: A systematic review and meta-analysis","volume":"68","author":"Davis","year":"2020","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1038\/s41598-020-63035-2","article-title":"The cognitive effects of statins are modified by age","volume":"10","author":"Alsehli","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Jurcau, A., and Simion, A. (2021). Cognition, statins, and cholesterol in elderly ischemic stroke patients: A neurologist\u2019s perspective. Medicina, 57.","DOI":"10.3390\/medicina57060616"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e1435","DOI":"10.1212\/WNL.0000000000007174","article-title":"Effects of blood pressure and lipid lowering on cognition","volume":"92","author":"Bosch","year":"2019","journal-title":"Neurology"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3389\/fnins.2018.00383","article-title":"Alzheimer\u2019s disease and type 2 diabetes: A critical assessment of the shared pathological traits","volume":"12","author":"Chatterjee","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrneurol.2017.185","article-title":"Brain insulin resistance in type 2 diabetes and Alzheimer disease: Concepts and conundrums","volume":"14","author":"Arnold","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"255","DOI":"10.14740\/jocmr4144","article-title":"Cognitive function assessment in patients on moderate-or high-intensity statin therapy","volume":"12","author":"Roy","year":"2020","journal-title":"J. Clin. Med. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000503105","article-title":"Association between use of statin and risk of dementia: A meta-analysis of observational studies","volume":"54","author":"Poly","year":"2020","journal-title":"Neuroepidemiology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.06.036","article-title":"Statin use and the risk of dementia in patients with stroke: A nationwide population-based cohort study","volume":"27","author":"Pan","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1212\/WNL.0000000000004818","article-title":"Comparative effect of statins on the risk of incident Alzheimer disease","volume":"90","author":"Sinyavskaya","year":"2018","journal-title":"Neurology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1001\/jamacardio.2017.0083","article-title":"Long-term safety and efficacy of achieving very low levels of low-density lipoprotein cholesterol: A prespecified analysis of the IMPROVE-IT Trial","volume":"2","author":"Giugliano","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJMoa1701131","article-title":"EBBINGHAUS Investigators. Cognitive function in a randomized trial of evolocumab","volume":"377","author":"Giugliano","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e200281","DOI":"10.1148\/ryct.2020200281","article-title":"Coronary artery calcium scoring: New insights into clinical interpretation-lessons from the CAC Consortium","volume":"2","author":"Adelhoefer","year":"2020","journal-title":"Radiol. Cardiothorac. 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