{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:52:16Z","timestamp":1787028736288,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81900552"],"award-info":[{"award-number":["81900552"]}]},{"name":"National Natural Science Foundation of China","award":["JQX20005"],"award-info":[{"award-number":["JQX20005"]}]},{"name":"National Natural Science Foundation of China","award":["ZKX19015"],"award-info":[{"award-number":["ZKX19015"]}]},{"name":"National Natural Science Foundation of China","award":["2022-LCYJ-MS-13"],"award-info":[{"award-number":["2022-LCYJ-MS-13"]}]},{"name":"National Natural Science Foundation of China","award":["2022-LCYJ-MS-17"],"award-info":[{"award-number":["2022-LCYJ-MS-17"]}]},{"name":"Nanjing Health Science and Technology Development Fund for Distinguished Young Youths","award":["81900552"],"award-info":[{"award-number":["81900552"]}]},{"name":"Nanjing Health Science and Technology Development Fund for Distinguished Young Youths","award":["JQX20005"],"award-info":[{"award-number":["JQX20005"]}]},{"name":"Nanjing Health Science and Technology Development Fund for Distinguished Young Youths","award":["ZKX19015"],"award-info":[{"award-number":["ZKX19015"]}]},{"name":"Nanjing Health Science and Technology Development Fund for Distinguished Young Youths","award":["2022-LCYJ-MS-13"],"award-info":[{"award-number":["2022-LCYJ-MS-13"]}]},{"name":"Nanjing Health Science and Technology Development Fund for Distinguished Young Youths","award":["2022-LCYJ-MS-17"],"award-info":[{"award-number":["2022-LCYJ-MS-17"]}]},{"name":"Nanjing Medical Science and Technique Development Foundation","award":["81900552"],"award-info":[{"award-number":["81900552"]}]},{"name":"Nanjing Medical Science and Technique Development Foundation","award":["JQX20005"],"award-info":[{"award-number":["JQX20005"]}]},{"name":"Nanjing Medical Science and Technique Development Foundation","award":["ZKX19015"],"award-info":[{"award-number":["ZKX19015"]}]},{"name":"Nanjing Medical Science and Technique Development Foundation","award":["2022-LCYJ-MS-13"],"award-info":[{"award-number":["2022-LCYJ-MS-13"]}]},{"name":"Nanjing Medical Science and Technique Development Foundation","award":["2022-LCYJ-MS-17"],"award-info":[{"award-number":["2022-LCYJ-MS-17"]}]},{"name":"Special Fund Project for Clinical Research of Nanjing Drum Tower Hospital","award":["81900552"],"award-info":[{"award-number":["81900552"]}]},{"name":"Special Fund Project for Clinical Research of Nanjing Drum Tower Hospital","award":["JQX20005"],"award-info":[{"award-number":["JQX20005"]}]},{"name":"Special Fund Project for Clinical Research of Nanjing Drum Tower Hospital","award":["ZKX19015"],"award-info":[{"award-number":["ZKX19015"]}]},{"name":"Special Fund Project for Clinical Research of Nanjing Drum Tower Hospital","award":["2022-LCYJ-MS-13"],"award-info":[{"award-number":["2022-LCYJ-MS-13"]}]},{"name":"Special Fund Project for Clinical Research of Nanjing Drum Tower Hospital","award":["2022-LCYJ-MS-17"],"award-info":[{"award-number":["2022-LCYJ-MS-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Wedge hepatic vein pressure (WHVP) accurately estimates the portal pressure (PP) in chronic sinusoidal portal hypertension patients. Whether this applies to patients with acute portal hypertension due to hepatic sinusoidal obstruction syndrome (HSOS) is unclear. Our aim was to assess the agreement between WHVP and PP in patients with HSOS by comparing them to decompensated cirrhosis patients. Methods: From December 2013 to December 2021, patients with pyrrolidine alkaloid-induced HSOS (PA-HSOS) receiving hepatic venous pressure gradient (HVPG) measurement and transjugular intrahepatic portosystem shunt (TIPS) were retrospectively collected and matched with those of patients with virus- or alcohol-related cirrhosis as a cirrhosis group. Pearson\u2019s correlation (R), intraclass correlation coefficient (ICC), scatter plots, and the Bland\u2013Altman method were performed for agreement evaluation. Results: A total of 64 patients were analyzed (30 PA-HSOS and 34 cirrhosis groups). The correlation between WHVP and PP was moderate in the PA-HSOS group (R: 0.58, p = 0.001; ICC: 0.68, p = 0.002) but good in the cirrhosis group (R: 0.81, p &lt; 0.001; ICC: 0.90, p &lt; 0.001). The percentage of patients with inconsistent WHVP and PP in the two groups was 13 (43.3%) and 15 (26.5%) (p = 0.156), respectively, and an overestimation of PP was more common in the PA-HSOS group (33.3% vs. 2.9%, p = 0.004). HVPG and portal pressure gradient (PPG) consistency was poor in both groups (R: 0.51 vs. 0.26; ICC: 0.65 vs. 0.41; p &lt; 0.05). Conclusions: WHVP in patients with PA-HSOS did not estimate PP as accurately as in patients with virus- or alcohol-related cirrhosis, which was mainly due to PP overestimation.<\/jats:p>","DOI":"10.3390\/jpm13010004","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T02:31:33Z","timestamp":1671589893000},"page":"4","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Agreement between Wedged Hepatic Venous Pressure and Portal Pressure in Hepatic Sinusoidal Obstruction Syndrome"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-624X","authenticated-orcid":false,"given":"Yang","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"},{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3117-1406","authenticated-orcid":false,"given":"Lihong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical School of Southeast University Nanjing Drum Tower Hospital, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangqiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzheng","family":"Zhuge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"},{"name":"Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41598-020-80136-0","article-title":"Validation and comparison of non-invasive prediction models based on liver stiffness measurement to identify patients who could avoid gastroscopy","volume":"11","author":"Hu","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.mayocp.2018.12.020","article-title":"Portal Hypertension and Related Complications: Diagnosis and Management","volume":"94","author":"Simonetto","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2009.149","article-title":"The clinical use of HVPG measurements in chronic liver disease","volume":"6","author":"Bosch","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.dld.2005.02.009","article-title":"Assessment of the agreement between wedge hepatic vein pressure and portal vein pressure in cirrhotic patients","volume":"37","author":"Thalheimer","year":"2005","journal-title":"Dig. Liver Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0168-8278(89)90141-4","article-title":"Comparison between portal vein pressure and wedged hepatic vein pressure in hepatitis B-related cirrhosis","volume":"9","author":"Lin","year":"1989","journal-title":"J. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41401-020-00553-9","article-title":"Tu-San-Qi (Gynura japonica): The culprit behind pyrrolizidine alkaloid-induced liver injury in China","volume":"42","author":"Zhu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jhep.2010.07.031","article-title":"Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum","volume":"54","author":"Lin","year":"2010","journal-title":"J. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (2016). EASL Clinical Practice Guidelines: Vascular diseases of the liver. J. Hepatol., 64, 179\u2013202.","DOI":"10.1016\/j.jhep.2015.07.040"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cld.2019.07.007","article-title":"Portal Hypertension: Pathogenesis and Diagnosis","volume":"23","author":"Turco","year":"2019","journal-title":"Clin. Liver Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1053\/gast.1996.v111.pm8780575","article-title":"Prognostic value of hepatic venous pressure gradient measurements in alcoholic cirrhosis: A 10-year prospective study","volume":"111","author":"Vorobioff","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/jgh.14612","article-title":"Expert consensus on the clinical management of pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome","volume":"34","author":"Zhuge","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/MEG.0000000000000134","article-title":"Different scoring systems in predicting survival in Chinese patients with liver cirrhosis undergoing transjugular intrahepatic portosystemic shunt","volume":"26","author":"Zhang","year":"2014","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/MEG.0000000000001349","article-title":"Comparison of transjugular intrahepatic portosystemic shunt for treatment of variceal bleeding in patients with cirrhosis with or without spontaneous portosystemic shunt","volume":"31","author":"Leng","year":"2019","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jhep.2020.10.003","article-title":"Agreement between wedged hepatic venous pressure and portal pressure in non-alcoholic steatohepatitis-related cirrhosis","volume":"74","author":"Bassegoda","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hep.510300628","article-title":"Wedged hepatic venous pressure adequately reflects portal pressure in hepatitis C virus-related cirrhosis","volume":"30","author":"Escorsell","year":"1999","journal-title":"Hepatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.3748\/wjg.v25.i28.3753","article-title":"Pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome: Pathogenesis, clinical manifestations, diagnosis, treatment, and outcomes","volume":"25","author":"Yang","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1111\/liv.13684","article-title":"Clinical characteristics and treatment of pyrrolizidine alkaloid-related hepatic vein occlusive disease","volume":"38","author":"Zhuge","year":"2018","journal-title":"Liver Int."},{"key":"ref_18","first-page":"959","article-title":"Renewing consensus in portal hypertension","volume":"76","author":"Bosch","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s12072-021-10293-5","article-title":"Development of a Drum Tower Severity Scoring (DTSS) system for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome","volume":"16","author":"Wang","year":"2022","journal-title":"Hepatol. Int."},{"key":"ref_20","first-page":"251","article-title":"Efficacy of transjugular intrahepatic portosystemic shunt in the treatment of 21 patients with Gynura segetum-related hepatic sinusoidal obstruction syndrome","volume":"39","author":"Hou","year":"2019","journal-title":"Chin. J. Digest."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/hep.20062","article-title":"The hepatic venous pressure gradient: Anything worth doing should be done right","volume":"39","author":"Groszmann","year":"2004","journal-title":"Hepatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1007\/s10620-008-0491-8","article-title":"Hepatic venous pressure gradient: Worth another look?","volume":"54","author":"Parikh","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.dld.2011.03.002","article-title":"Hepatic venous pressure gradient measurement in clinical hepatology","volume":"43","author":"Merkel","year":"2011","journal-title":"Dig. Liver Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/00365515309094199","article-title":"Estimation of Portal Venous Pressure by Occlusive Hepatic Vein Catheterization","volume":"5","author":"Krook","year":"1953","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.gie.2020.06.065","article-title":"EUS-guided portal pressure gradient measurement in patients with acute or subacute portal hypertension","volume":"93","author":"Zhang","year":"2020","journal-title":"Gastrointest. Endosc."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (2019). EASL Clinical Practice Guideline: Occupational liver diseases. J. Hepatol., 71, 1022\u20131037.","DOI":"10.1016\/j.jhep.2019.08.008"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s12072-020-10126-x","article-title":"Risk factors of poor prognosis in patients with pyrrolidine alkaloid-induced hepatic sinusoidal obstruction syndrome after transjugular intrahepatic portosystemic shunt","volume":"15","author":"Xiao","year":"2021","journal-title":"Hepatol. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1026622721389","article-title":"Portohepatic gradient and portal hemodynamics in patients with cirrhosis due to hepatitis C virus infection","volume":"44","author":"Deplano","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/liv.12229","article-title":"Impact of deep sedation on the accuracy of hepatic and portal venous pressure measurements in patients with cirrhosis","volume":"34","author":"Reverter","year":"2013","journal-title":"Liver Int."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/1\/4\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:44:46Z","timestamp":1760147086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/1\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jpm13010004"],"URL":"https:\/\/doi.org\/10.3390\/jpm13010004","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]}}}