{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:25:13Z","timestamp":1767626713539,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Ankylosing spondylitis (AS) is an inflammatory disease that involves the axial skeleton and can present with extra-articular manifestations. However, there are scarce reports describing the link between AS and pulmonary arterial hypertension (PAH). Herein, we report on a 58-year-old man with a history of AS for 32 years who developed PAH as confirmed by echocardiography and right cardiac catheterization. To our knowledge, this is the first case of AS associated with PAH 32 years after the AS diagnosis with a detailed clinical description. We are recommended that physicians should be aware of this rare comorbidity in AS patients. Early echocardiographic screening is necessary for symptomatic patients.<\/jats:p>","DOI":"10.3390\/jpm13010062","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T08:38:19Z","timestamp":1672216699000},"page":"62","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: A Rare Manifestation of Pulmonary Arterial Hypertension in Ankylosing Spondylitis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-153X","authenticated-orcid":false,"given":"Tsung-Yuan","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"},{"name":"Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-6696","authenticated-orcid":false,"given":"Yong-Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Occupational Safety and Health, Chung Shan Medical University Hospital, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wun-Zhih","family":"Siao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"},{"name":"Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-5497","authenticated-orcid":false,"given":"Gwo-Ping","family":"Jong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan"},{"name":"Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1136\/annrheumdis-2013-203582","article-title":"Prevalence of extra-articular manifestations in patients with ankylosing spondylitis: A systematic review and meta-analysis","volume":"74","author":"Stolwijk","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e010016","DOI":"10.1161\/JAHA.118.010016","article-title":"Lifetime risks of valvular heart disease and pacemaker use in patients with ankylosing spondylitis","volume":"7","author":"Ward","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ccm.2010.05.002","article-title":"Pulmonary manifestations of ankylosing spondylitis","volume":"31","author":"Kanathur","year":"2010","journal-title":"Clin. Chest Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1164\/rccm.202012-4317SO","article-title":"Pulmonary arterial hypertension: Diagnosis, treatment, and novel advances","volume":"203","author":"Maron","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jbspin.2010.11.003","article-title":"Aortitis and periaortitis in ankylosing spondylitis","volume":"78","author":"Palazzi","year":"2011","journal-title":"Jt. Bone Spine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Humbert","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_7","first-page":"31","article-title":"Pulmonary hypertension, involvement of the right and left cardiac parts in patients with ankylosing spondylarthritis","volume":"82","author":"Karoli","year":"2004","journal-title":"Klin. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2169\/internalmedicine.54.3160","article-title":"Ankylosing spondylitis associated with pulmonary arterial hypertension","volume":"54","author":"Hung","year":"2015","journal-title":"Intern. Med."},{"key":"ref_9","first-page":"72","article-title":"Pulmonary hypertension in patients with ankylosing spondilitis: Main factors of development","volume":"80","author":"Rebrov","year":"2008","journal-title":"Ter. Arkh."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jcmg.2014.12.003","article-title":"Pulmonary hypertension in valvular disease: A comprehensive review on pathophysiology to therapy from the HAVEC Group","volume":"8","author":"Magne","year":"2015","journal-title":"JACC Cardiovasc. Imaging."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1759720X211021676","DOI":"10.1177\/1759720X211021676","article-title":"Increased risk of valvular heart disease in patients with ankylosing spondylitis: A nationwide population-based longitudinal cohort study","volume":"13","author":"Siao","year":"2021","journal-title":"Ther. Adv. Musculoskelet. Dis."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/1\/62\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:53:34Z","timestamp":1760147614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/1\/62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,28]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jpm13010062"],"URL":"https:\/\/doi.org\/10.3390\/jpm13010062","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2022,12,28]]}}}