{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T10:33:39Z","timestamp":1783247619840,"version":"3.54.6"},"reference-count":34,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education","award":["2021R1F1A1048113"],"award-info":[{"award-number":["2021R1F1A1048113"]}]},{"name":"Ministry of Education","award":["2021R1I1A1A01059868"],"award-info":[{"award-number":["2021R1I1A1A01059868"]}]},{"name":"Ministry of Education","award":["2020R1I1A1A01060447"],"award-info":[{"award-number":["2020R1I1A1A01060447"]}]},{"name":"Ministry of Education","award":["2022-0-00621"],"award-info":[{"award-number":["2022-0-00621"]}]},{"name":"Ministry of Education","award":["HI22C073600"],"award-info":[{"award-number":["HI22C073600"]}]},{"name":"Korean government (MSIT)","award":["2021R1F1A1048113"],"award-info":[{"award-number":["2021R1F1A1048113"]}]},{"name":"Korean government (MSIT)","award":["2021R1I1A1A01059868"],"award-info":[{"award-number":["2021R1I1A1A01059868"]}]},{"name":"Korean government (MSIT)","award":["2020R1I1A1A01060447"],"award-info":[{"award-number":["2020R1I1A1A01060447"]}]},{"name":"Korean government (MSIT)","award":["2022-0-00621"],"award-info":[{"award-number":["2022-0-00621"]}]},{"name":"Korean government (MSIT)","award":["HI22C073600"],"award-info":[{"award-number":["HI22C073600"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["2021R1F1A1048113"],"award-info":[{"award-number":["2021R1F1A1048113"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["2021R1I1A1A01059868"],"award-info":[{"award-number":["2021R1I1A1A01059868"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["2020R1I1A1A01060447"],"award-info":[{"award-number":["2020R1I1A1A01060447"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["2022-0-00621"],"award-info":[{"award-number":["2022-0-00621"]}]},{"name":"Ministry of Health &amp; Welfare, Republic of Korea","award":["HI22C073600"],"award-info":[{"award-number":["HI22C073600"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Retinal vascular occlusions are a common cause of visual loss. The association between oral health and the risk of retinal vascular occlusions remains unknown. We investigated whether oral health was associated with the risk of retinal vascular occlusions. We conducted a retrospective cohort study including 138,484 participants who completed a national health screening program with an oral health examination from the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) 2002\u20132015. Oral health markers, such as the presence of periodontitis, tooth loss, and dental caries, and the frequency of daily tooth brushing, were evaluated. The primary outcome was the occurrence of retinal vascular occlusions up to December 2015. In total, 2533 participants developed retinal vascular occlusions (215 with retinal artery occlusion, 1686 with retinal vein occlusion, 632 with unspecified retinal vascular occlusion). In the multivariable Cox regression analysis, periodontitis was an independent risk factor for retinal vascular occlusions (adjusted hazard ratio: 1.18; 95% confidence interval: 1.02\u20131.36; p = 0.024). Frequent tooth brushing was negatively associated with the risk of retinal vascular occlusions (adjusted hazard ratio: 0.89; 95% confidence interval: 0.80\u20130.98; p = 0.022). Improving oral hygiene may contribute to the attenuation of the risk of retinal vascular occlusions.<\/jats:p>","DOI":"10.3390\/jpm13010121","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T01:48:19Z","timestamp":1672969699000},"page":"121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oral Health and Risk of Retinal Vascular Occlusions: A Nationwide Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-2278","authenticated-orcid":false,"given":"Yoonkyung","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-3914","authenticated-orcid":false,"given":"Jimin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si 16995, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-762X","authenticated-orcid":false,"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-9736","authenticated-orcid":false,"given":"Jinkwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si 16995, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.ophtha.2009.03.006","article-title":"Retinal artery occlusion: Associated systemic and ophthalmic abnormalities","volume":"116","author":"Hayreh","year":"2009","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"The Central Vein Occlusion Study Group (1997). 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