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Female hormone fluctuation influences gastrointestinal symptoms, pain perception, and the state of active disease at the time of conception could negatively affect the pregnancy. Women with inflammatory bowel disease report a worse quality of life, higher psychological distress, and reduced sexual activity than male patients. This narrative review aims to resume the current knowledge of female-related features in clinical manifestations, development, and therapy, as well as sexual and psychological implications related to inflammatory bowel disease. The final attempt is to provide gastroenterologists with a roadmap of female-specific differences, to improve patients\u2019 diagnosis, management, and treatment.<\/jats:p>","DOI":"10.3390\/jpm13020165","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T03:41:52Z","timestamp":1673926912000},"page":"165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Impact of Female Gender in Inflammatory Bowel Diseases: A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Lisa","family":"Lungaro","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, St. Anna Hospital, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-1135","authenticated-orcid":false,"given":"Anna","family":"Costanzini","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, St. Anna Hospital, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2898-4323","authenticated-orcid":false,"given":"Francesca","family":"Manza","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, St. Anna Hospital, University of Ferrara, 44124 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Barbalinardo","sequence":"additional","affiliation":[{"name":"National Research Council, Institute for the Study of Nanostructured Materials (CNR-ISMN), Via P. 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