{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T10:38:57Z","timestamp":1785839937366,"version":"3.56.0"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bio &amp; Medical Technology Development Program of the National Research Foundation (NRF)","award":["NRF-2021R1C1C1005746"],"award-info":[{"award-number":["NRF-2021R1C1C1005746"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This study aimed to investigate the possible link between glaucoma and dementia using a nationwide cohort sample of data. The glaucoma group (n = 875) included patients diagnosed between 2003 and 2005, aged over 55 years; the comparison group was selected using propensity score matching (n = 3500). The incidence of all-cause dementia was 18.67 (7014.7 person-years) among those with glaucoma aged over 55 years. The glaucoma group developed all-cause dementia more frequently than those in the comparison group (adjusted hazard ratio (HR) = 1.43, 95% confidence interval (CI), 1.17\u20131.74). In a subgroup analysis, primary open-angle glaucoma (POAG) showed a significantly increased adjusted HR for all-cause dementia events (1.52, 95% CI: 1.23\u20131.89), whereas we could not find any significant association in patients with primary angle-closure glaucoma (PACG). Additionally, POAG patients showed an increased risk of the development of Alzheimer\u2019s disease (adjusted HR = 1.57, 95% CI, 1.21\u20132.04) and Parkinson\u2019s disease (adjusted HR = 2.29, 95% CI, 1.46\u20133.61), but there was no significant difference in PACG patients. Moreover, the risk of Alzheimer\u2019s disease and Parkinson\u2019s disease was higher within 2 years of POAG diagnosis. Although our findings have some limitations, such as confounding factor bias, we suggest that clinicians should pay attention to the early detection of dementia in patients with POAG.<\/jats:p>","DOI":"10.3390\/jpm13020214","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T01:27:58Z","timestamp":1674782878000},"page":"214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-0177","authenticated-orcid":false,"given":"Dong-Kyu","family":"Kim","sequence":"first","affiliation":[{"name":"Institute of New Frontier Research, Division of Big Data and Artificial Intelligence, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nune Eye Hospital, Seoul 06198, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0140-6736(10)61423-7","article-title":"Glaucoma","volume":"377","author":"Quigley","year":"2011","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(08)01101-1","article-title":"Epidemiology of primary glaucoma: Prevalence, incidence, and blinding effects","volume":"173","author":"Cedrone","year":"2008","journal-title":"Prog. Brain Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pneurobio.2016.07.005","article-title":"Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson\u2019s disease and Alzheimer\u2019s disease","volume":"147","author":"Jiang","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer\u2019s disease: A prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Lin, I.-C., Wang, Y.-H., Wang, T.-J., Wang, I.-J., Shen, Y.-D., Chi, N.-F., and Chien, L.-N. (2014). Glaucoma, Alzheimer\u2019s Disease, and Parkinson\u2019s Disease: An 8-Year Population-Based Follow-Up Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108938"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/eye.2015.120","article-title":"Dementia is associated with open-angle glaucoma: A population-based study","volume":"29","author":"Chung","year":"2015","journal-title":"Eye"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-29557-6","article-title":"Association between Open-Angle Glaucoma and the Risks of Alzheimer\u2019s and Parkinson\u2019s Diseases in South Korea: A 10-year Nationwide Cohort Study","volume":"8","author":"Moon","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/09286586.2011.649228","article-title":"Glaucoma, Alzheimer Disease and Other Dementia: A Longitudinal Analysis","volume":"19","author":"Ou","year":"2012","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_9","first-page":"47","article-title":"No Increased Risk of Developing Alzheimer Disease in Patients with Glaucoma","volume":"16","author":"Kessing","year":"2007","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_10","first-page":"406","article-title":"Risk Factors and Open-angle Glaucoma: Classification and Application","volume":"16","author":"Boland","year":"2007","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1167\/iovs.08-2228","article-title":"Intracranial Pressure in Primary Open Angle Glaucoma, Normal Tension Glaucoma, and Ocular Hypertension: A Case\u2013Control Study","volume":"49","author":"Berdahl","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1111\/aos.12551","article-title":"Cerebrospinal fluid pressure trends in diseases associated with primary open-angle glaucoma","volume":"93","author":"Fleischman","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s10384-004-0156-x","article-title":"Vitreous fluid levels of \u03b2-amyloid(1\u201342) and tau in patients with retinal diseases","volume":"49","author":"Yoneda","year":"2005","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3129\/i07-185","article-title":"Retinal tau pathology in human glaucomas","volume":"43","author":"Gupta","year":"2008","journal-title":"Can. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1523\/JNEUROSCI.3986-15.2016","article-title":"Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma","volume":"36","author":"Chiasseu","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4103\/2008-322X.163766","article-title":"Senile dementia and glaucoma: Evidence for a common link","volume":"10","author":"Aref","year":"2015","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1111\/aos.12298","article-title":"Ocular perfusion pressure in glaucoma","volume":"92","author":"Costa","year":"2014","journal-title":"Acta Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1073\/pnas.0608251104","article-title":"Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer\u2019s phenotype","volume":"104","author":"Chow","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S1474-4422(14)70136-X","article-title":"Potential for primary prevention of Alzheimer\u2019s disease: An analysis of population-based data","volume":"13","author":"Norton","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lee, I.H., Yu, H., Ha, S.-S., Son, G.M., Park, K.J., Lee, J.J., and Kim, D.-K. (2021). Association between Late-Onset M\u00e9ni\u00e8re\u2019s Disease and the Risk of Incident All-Cause Dementia. J. Pers. Med., 12.","DOI":"10.3390\/jpm12010019"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kwon, Y.-S., Lee, J.-J., Lee, S.-H., Kim, C., Yu, H., Sohn, J.-H., and Kim, D.-K. (2021). Risk of Dementia in Patients Who Underwent Surgery under Neuraxial Anesthesia: A Nationwide Cohort Study. J. Pers. Med., 11.","DOI":"10.3390\/jpm11121386"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.sleep.2013.11.790","article-title":"Association between glaucoma and sleep apnea in a large French multicenter prospective cohort","volume":"15","author":"Aptel","year":"2014","journal-title":"Sleep Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0002-9394(01)01196-5","article-title":"Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"133","author":"Bayer","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.parkreldis.2007.07.018","article-title":"Visual field analysis in patients with Parkinson\u2019s disease","volume":"14","author":"Yenice","year":"2008","journal-title":"Park. Relat. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10633-007-9091-8","article-title":"Correlation between retinal morphological and functional findings and clinical severity in Parkinson\u2019s disease","volume":"116","author":"Altintas","year":"2008","journal-title":"Doc. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5301\/EJO.2010.1318","article-title":"Morphologic Changes and Functional Retinal Impairment in Patients with Parkinson Disease without Visual Loss","volume":"21","author":"Moschos","year":"2010","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/bjo.54.3.161","article-title":"Aetiology of the anatomical basis for primary angle-closure glaucoma. Biometrical comparisons between normal eyes and eyes with primary angle-closure glaucoma","volume":"54","author":"Lowe","year":"1970","journal-title":"Br. J. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/sj.eye.6702687","article-title":"Study of biometric parameters in family members of primary angle closure glaucoma patients","volume":"22","author":"Sihota","year":"2008","journal-title":"Eye"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14045","DOI":"10.1038\/s41598-021-93522-z","article-title":"Detection of unknown ototoxic adverse drug reactions: An electronic healthcare record-based longitudinal nationwide cohort analysis","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_30","first-page":"dyv319","article-title":"Cohort Profile: The National Health Insurance Service\u2013National Sample Cohort (NHIS-NSC), South Korea","volume":"46","author":"Lee","year":"2016","journal-title":"Leuk. Res."},{"key":"ref_31","first-page":"467","article-title":"Conversion of National Health Insurance Service-National Sample Cohort (NHIS-NSC) Database into Observational Medical Outcomes Partnership-Common Data Model (OMOP-CDM)","volume":"245","author":"You","year":"2017","journal-title":"Stud. Health Technol. Inform."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/2\/214\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:16:01Z","timestamp":1760120161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/2\/214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,26]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["jpm13020214"],"URL":"https:\/\/doi.org\/10.3390\/jpm13020214","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,26]]}}}