{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:16:30Z","timestamp":1790356590648,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) in the most severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with dupilumab in different rhinological units were followed up at 1, 3, 6 and 12 months from the first administration and were considered for this study. At baseline (T0) and at each follow-up, patients underwent nasal endoscopy and completed the sinonasal outcome test (SNOT)-22, a visual analogue scale (VAS) for smell\/nasal obstruction, peak nasal inspiratory flow (PNIF) and the Sniffin\u2019 Sticks identification test (SSIT). The aim of the present study was to evaluate the effects of dupilumab in patients with severe uncontrolled CRSwNP on recovering nasal obstruction and smell impairment. Moreover, the method between PNIF and SSIT with the highest correlation with patients\u2019 response to dupilumab was evaluated. One hundred forty-seven patients were included. All parameters improved during treatment (p &lt; 0.001). At T0, no correlations were found between PNIF and nasal symptoms. Nevertheless, during the following evaluations significant correlations between PNIF changes and both nasal symptoms and NPS were observed (p &lt; 0.05). At T0, SSIT did not correlate with SNOT-22. Similarly to PNIF, during the follow-up SSIT changes significantly correlated with nasal symptom and NPS (p &lt; 0.05). Comparing PNIF and SSIT correlations with SNOT-22 and NPS, PNIF showed a higher correlation with both. Dupilumab improves nasal obstruction and the sense of smell. PNIF and SSIT are effective tools in monitoring patients\u2019 response to dupilumab.<\/jats:p>","DOI":"10.3390\/jpm13020234","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:56:27Z","timestamp":1675050987000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Measuring Nasal Patency and the Sense of Smell in CRSwNP Patients Treated with Dupilumab"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-4761","authenticated-orcid":false,"given":"Giancarlo","family":"Ottaviano","sequence":"first","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5761-7018","authenticated-orcid":false,"given":"Eugenio","family":"De Corso","sequence":"additional","affiliation":[{"name":"ENT Department of A. Gemelli Unversitary Hospital IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cantone","sequence":"additional","affiliation":[{"name":"Reproductive and Odontostomatological Sciences-ENT Section, Department of Neuroscience, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciofalo","sequence":"additional","affiliation":[{"name":"Rhinology Unit, Department of Sensory Organs, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8349-9569","authenticated-orcid":false,"given":"Tommaso","family":"Saccardo","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Mairani","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2070-0314","authenticated-orcid":false,"given":"Claudio","family":"Montuori","sequence":"additional","affiliation":[{"name":"ENT Department of A. Gemelli Unversitary Hospital IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Roccuzzo","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Soldati","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto","family":"Randon","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonny","family":"Zampollo","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Di","family":"Chicco","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Visconti","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9628-5164","authenticated-orcid":false,"given":"Bruno","family":"Scarpa","sequence":"additional","affiliation":[{"name":"Department of Statistical Sciences, University of Padova, 35100 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neurosciences DNS, University of Padova, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1007\/s00405-014-3456-x","article-title":"Endoglin (CD105) Expression in Sinonasal Polyposis","volume":"272","author":"Ottaviano","year":"2015","journal-title":"Eur. 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