{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:58:37Z","timestamp":1786989517066,"version":"build-2736575974"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research University Grant","award":["GPF002C-2018"],"award-info":[{"award-number":["GPF002C-2018"]}]},{"name":"Research University Grant","award":["GA012-2020"],"award-info":[{"award-number":["GA012-2020"]}]},{"name":"Research University Grant","award":["LG010-2019"],"award-info":[{"award-number":["LG010-2019"]}]},{"name":"Malaysian Brain, Mind and Neuroscience Research Foundation","award":["GPF002C-2018"],"award-info":[{"award-number":["GPF002C-2018"]}]},{"name":"Malaysian Brain, Mind and Neuroscience Research Foundation","award":["GA012-2020"],"award-info":[{"award-number":["GA012-2020"]}]},{"name":"Malaysian Brain, Mind and Neuroscience Research Foundation","award":["LG010-2019"],"award-info":[{"award-number":["LG010-2019"]}]},{"name":"Ministry of Higher Education Malaysia Long-term Research Grant Scheme","award":["GPF002C-2018"],"award-info":[{"award-number":["GPF002C-2018"]}]},{"name":"Ministry of Higher Education Malaysia Long-term Research Grant Scheme","award":["GA012-2020"],"award-info":[{"award-number":["GA012-2020"]}]},{"name":"Ministry of Higher Education Malaysia Long-term Research Grant Scheme","award":["LG010-2019"],"award-info":[{"award-number":["LG010-2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>SLC1A2 is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of neurological diseases and psychiatric disorders. Our study investigated the association of rs4755404 single nucleotide polymorphism (SNP) of the SLC1A2 gene with methamphetamine (METH) dependence and METH-induced psychosis and mania in a Malaysian population. The rs4755404 gene polymorphism was genotyped in METH-dependent male subjects (n = 285) and male control subjects (n = 251). The subjects consisted of the four ethnic groups in Malaysia (Malay, Chinese, Kadazan-Dusun, and Bajau). Interestingly, there was a significant association between rs4755404 polymorphism and METH-induced psychosis in the pooled METH-dependent subjects in terms of genotype frequency (p = 0.041). However, there was no significant association between rs4755404 polymorphism and METH dependence. Also, the rs455404 polymorphism was not significantly associated with METH-induced mania for both genotype frequencies and allele frequencies in the METH-dependent subjects, regardless of stratification into the different ethnicities. Our study suggests that the SLC1A2 rs4755404 gene polymorphism confers some susceptibility to METH-induced psychosis, especially for those who carry the GG homozygous genotype.<\/jats:p>","DOI":"10.3390\/jpm13020270","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:52:02Z","timestamp":1675219922000},"page":"270","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis"],"prefix":"10.3390","volume":"13","author":[{"given":"Dayang Nooreffazleen","family":"Yahya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2453-3760","authenticated-orcid":false,"given":"Rhanye Mac","family":"Guad","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Therapeutics, Faculty of Medicine and Health Science, Universiti Malaysia Sabah, Kota Kinabalu 88400, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-8049","authenticated-orcid":false,"given":"Yuan-Seng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya 47500, Malaysia"},{"name":"Centre for Virus and Vaccine Research, School of Medical and Life Sciences, Sunway University, Subang Jaya 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-3651","authenticated-orcid":false,"given":"Siew Hua","family":"Gan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-4687","authenticated-orcid":false,"given":"Subash C. B.","family":"Gopinath","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Technology, Universiti Malaysia Perlis, Arau 02600, Malaysia"},{"name":"Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, Kangar 01000, Malaysia"},{"name":"Micro System Technology, Centre of Excellence (CoE), Universiti Malaysia Perlis (UniMAP), Pauh Campus, Arau 02600, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5866-6292","authenticated-orcid":false,"given":"Hasif Adli","family":"Zakariah","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusdi Abdul","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7848-0775","authenticated-orcid":false,"given":"Maw Shin","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","unstructured":"United Nations Office on Drugs and Crime (2022, November 23). Synthetic Drugs in East and South-East Asia Trends and Patterns of Am-phetamine-Type Stimulants and New Psychoactive Substances. A Report from the Global SMART Programme March 2019. Available online: https:\/\/www.unodc.org\/documents\/southeastasiaandpacific\/Publications\/2019\/2019_The_Challenge_of_Synthetic_Drugs_in_East_and_SEA.pdf."},{"key":"ref_2","unstructured":"National Anti-Drugs Agency Malaysia (2022, November 23). Drug Statistics, Available online: https:\/\/www.adk.gov.my\/en\/public\/drugs-statistics\/."},{"key":"ref_3","unstructured":"United Nations Office on Drugs and Crime (2022, November 23). Methamphetamine Continues to Dominate Synthetic Drug Markets, Global SMART Update Volume 20. Available online: https:\/\/www.unodc.org\/documents\/scientific\/Global_Smart_Update_20_web.pdf."},{"key":"ref_4","unstructured":"National Center for Biotechnology Information (2022, November 23). SLC1A2 Solute Carrier Family 1 Member 2 [Homo Sapiens (Human)], Available online: https:\/\/www.ncbi.nlm.nih.gov\/gene\/6506."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mam.2013.01.001","article-title":"The SLC1 high-affinity glutamate and neutral amino acid transporter family","volume":"34","author":"Kanai","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1124\/dmd.121.000705","article-title":"Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity","volume":"50","author":"Sheng","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1007\/s00018-015-1937-8","article-title":"Glutamate transporter EAAT2: Regulation, function, and potential as a therapeutic target for neurological and psychiatric disease","volume":"72","author":"Takahashi","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/glia.20119","article-title":"Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics","volume":"49","author":"Matute","year":"2004","journal-title":"Glia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1001\/jamapsychiatry.2013.3939","article-title":"Increased Glutamine in Patients Undergoing Long-term Treatment for Schizophrenia: A proton magnetic resonance spectroscopy study at 3 T","volume":"71","author":"Bustillo","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1523\/JNEUROSCI.5129-07.2008","article-title":"Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking","volume":"28","author":"Lalumiere","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1523\/JNEUROSCI.23-08-03531.2003","article-title":"Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior","volume":"23","author":"McFarland","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41386-018-0027-7","article-title":"Psychostimulant drug effects on glutamate, Glx, and creatine in the anterior cingulate cortex and subjective response in healthy humans","volume":"43","author":"White","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fpsyt.2018.00368","article-title":"Increased Absolute Glutamate Concentrations and Glutamate-to-Creatine Ratios in Patients with Methamphetamine Use Disorders","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00041444-200010030-00001","article-title":"Genetic variation of the glutamate transporter EAAT2 gene and vulnerability to alcohol dependence","volume":"10","author":"Sander","year":"2000","journal-title":"Psychiatr. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bcp.2007.06.039","article-title":"Glutamatergic substrates of drug addiction and alcoholism","volume":"75","author":"Gass","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41398-019-0483-9","article-title":"Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling","volume":"9","author":"Veldic","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"134128","DOI":"10.1016\/j.neulet.2019.02.046","article-title":"Pharmacogenetics of drug dependence: Polymorphisms of genes involved in glutamate neurotransmission","volume":"726","author":"Iamjan","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1196\/annals.1316.035","article-title":"Clinical Features of Sensitization to Methamphetamine Observed in Patients with Methamphetamine Dependence and Psychosis","volume":"1025","author":"Ujike","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Bulatao, R.A., and Anderson, N.B. (2004). Understanding Racial and Ethnic Differences in Health in Late Life: A Research Agenda, National Academy Press.","DOI":"10.1037\/e305812005-001"},{"key":"ref_20","unstructured":"Chiarella, P., Capone, P., and Sisto, R. (2020). The Recent Topics in Genetic Polymorphisms, IntechOpen."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/ADM.0000000000000075","article-title":"Genetic Polymorphism in DTNBP1 Gene Is Associated with Methamphetamine-Induced Panic Disorder","volume":"8","author":"Sim","year":"2014","journal-title":"J. Addict. Med."},{"key":"ref_23","first-page":"22","article-title":"The Mini-International Neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diag-nostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000066696","article-title":"Power and Sample Size Calculations for Case-Control Genetic Association Tests when Errors Are Present: Application to Single Nucleotide Polymorphisms","volume":"54","author":"Gordon","year":"2002","journal-title":"Hum. Hered."},{"key":"ref_25","unstructured":"Gordon, D., Levenstien, M.A., Finch, S.J., and Ott, J. (2003, January 3\u20137). Errors and Linkage Disequilibrium Interact Multiplicatively when Computing Sample Sizes for Genetic Case-Control Association Studies. Proceedings of the Pacific Symposium on Biocomputing, Lihue, HI, USA."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40291-012-0004-5","article-title":"Influence of an Interaction between Lithium Salts and a Functional Polymorphism in SLC1A2 on the History of Illness in Bipolar Disorder","volume":"16","author":"Dallaspezia","year":"2012","journal-title":"Mol. Diagn. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2217\/pgs.13.25","article-title":"Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population","volume":"14","author":"Sim","year":"2013","journal-title":"Pharmacogenomics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2147\/NDT.S194924","article-title":"Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population","volume":"15","author":"Merk","year":"2019","journal-title":"Neuropsychiatr. Dis. 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