{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:43:53Z","timestamp":1777103033682,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Introduction: Millions of Americans infected with the severe acute respiratory syndrome-associated coronavirus-19 (COVID-19) need oncologic surgery. Patients with acute or resolved COVID-19 illness complain of neuropsychiatric symptoms. How surgery affects postoperative neuropsychiatric outcomes such as delirium is unknown. We hypothesize that patients with a history of COVID-19 could have an exaggerated risk of developing postoperative delirium after undergoing major elective oncologic surgery. Methods: We conducted a retrospective study to determine the association between COVID-19 status and antipsychotic drugs during postsurgical hospitalization as a surrogate of delirium. Secondary outcomes included 30 days of postoperative complications, length of stay, and mortality. Patients were grouped into pre-pandemic non-COVID-19 and COVID-19-positive groups. A 1:2 propensity score matching was used to minimize bias. A multivariable logistic regression model estimated the effects of important covariates on the use of postoperative psychotic medication. Results: A total of 6003 patients were included in the study. Pre- and post-propensity score matching demonstrated that a history of preoperative COVID-19 did not increase the risk of antipsychotic medications postoperatively. However, respiratory and overall 30-day complications were higher in COVID-19 individuals than in pre-pandemic non-COVID-19 patients. The multivariate analysis showed that the odds of using postoperative antipsychotic medication use for the patients who had COVID-19 compared to those who did not have the infection were not significantly different. Conclusion: A preoperative diagnosis of COVID-19 did not increase the risk of postoperative antipsychotic medication use or neurological complications. More studies are needed to reproduce our results due to the increased concern of neurological events post-COVID-19 infection.<\/jats:p>","DOI":"10.3390\/jpm13020274","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T02:52:02Z","timestamp":1675219922000},"page":"274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between COVID-19 and Postoperative Neurological Complications and Antipsychotic Medication Use after Cancer Surgery: A Retrospective Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Juan P.","family":"Cata","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, The University of Texas\u2014MD Anderson Cancer Centre, Houston, TX 77030, USA"},{"name":"Anesthesiology and Surgical Oncology Research Group, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, The University of Texas\u2014MD Anderson Cancer Centre, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, The University of Texas\u2014MD Anderson Cancer Centre, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The University of Texas\u2014MD Anderson Cancer Centre, Houston, TX 77030, USA"},{"name":"Data-Driven Determinants for COVID-19 Oncology Discovery Effort (D3CODE) Team, University of Texas\u2014MD Anderson Cancer Centre, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott E.","family":"Woodman","sequence":"additional","affiliation":[{"name":"Data-Driven Determinants for COVID-19 Oncology Discovery Effort (D3CODE) Team, University of Texas\u2014MD Anderson Cancer Centre, Houston, TX 77030, USA"},{"name":"Department of Genomic Medicine, The University of Texas\u2014MD Anderson Cancer Centre, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa A.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Gynecology Oncology and Reproductive Medicine, The University of Texas\u2014MD Anderson Cancer Centre, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S2213-2600(20)30304-0","article-title":"COVID-19-associated acute respiratory distress syndrome: Is a different approach to management warranted?","volume":"8","author":"Fan","year":"2020","journal-title":"Lancet Respir. 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