{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:00:14Z","timestamp":1787061614286,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T00:00:00Z","timestamp":1675468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Social Development Program of Jiangsu Province","award":["BE2021744"],"award-info":[{"award-number":["BE2021744"]}]},{"name":"Social Development Program of Jiangsu Province","award":["BK20191059"],"award-info":[{"award-number":["BK20191059"]}]},{"name":"Social Development Program of Jiangsu Province","award":["81900875"],"award-info":[{"award-number":["81900875"]}]},{"name":"Social Development Program of Jiangsu Province","award":["82070979"],"award-info":[{"award-number":["82070979"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["BE2021744"],"award-info":[{"award-number":["BE2021744"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["BK20191059"],"award-info":[{"award-number":["BK20191059"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["81900875"],"award-info":[{"award-number":["81900875"]}]},{"name":"Natural Science Foundation of Jiangsu Province","award":["82070979"],"award-info":[{"award-number":["82070979"]}]},{"name":"General Project of the National Natural Science","award":["BE2021744"],"award-info":[{"award-number":["BE2021744"]}]},{"name":"General Project of the National Natural Science","award":["BK20191059"],"award-info":[{"award-number":["BK20191059"]}]},{"name":"General Project of the National Natural Science","award":["81900875"],"award-info":[{"award-number":["81900875"]}]},{"name":"General Project of the National Natural Science","award":["82070979"],"award-info":[{"award-number":["82070979"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>(1) Background: The microstructural alterations of the peripapillary choriocapillaris in high myopes remain elusive. Here, we used optical coherence tomography angiography (OCTA) to explore factors involved in these alterations. (2) Methods: This cross-sectional control study included 205 young adults\u2019 eyes (95 with high myopia and 110 with mild to moderate myopia). The choroidal vascular network was imaged using OCTA, and the images underwent manual adjustments to determine the peripapillary atrophy (PPA)-\u03b2 zone and microvascular dropout (MvD). The area of MvD and the PPA-\u03b2 zone, spherical equivalent (SE), and axial length (AL) were collected and compared across groups. (3) Results: The MvD was identified in 195 eyes (95.1%). Highly myopic eyes exhibited a significantly greater area for the PPA-\u03b2 zone (1.221 \u00b1 0.073 vs. 0.562 \u00b1 0.383 mm2, p = 0.001) and MvD (0.248 \u00b1 0.191 vs. 0.089 \u00b1 0.082 mm2, p &lt; 0.001) compared with mildly to moderately myopic eyes, and a lower average density in the choriocapillaris. Linear regression analysis showed that the MvD area correlated with age, SE, AL, and the PPA-\u03b2 area (all p &lt; 0.05). (4) Conclusions: This study found that MvDs represent choroidal microvascular alterations in young-adult high myopes, which were correlated with age, SE, AL, and the PPA-\u03b2 zone. In this disorder, OCTA is important for characterizing the underlying pathophysiological adaptations.<\/jats:p>","DOI":"10.3390\/jpm13020289","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T02:57:32Z","timestamp":1675652252000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Microvascular Alterations of Peripapillary Choriocapillaris in Young Adult High Myopia Detected by Optical Coherence Tomography Angiography"],"prefix":"10.3390","volume":"13","author":[{"given":"Jie","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yangzhong People\u2019s Hospital, Yangzhong 212299, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1016\/S2214-109X(13)70113-X","article-title":"Causes of vision loss worldwide, 1990\u20132010: A systematic analysis","volume":"1","author":"Bourne","year":"2013","journal-title":"Lancet Glob. 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