{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:20:54Z","timestamp":1767896454299,"version":"3.49.0"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Infective endocarditis is a severe infective heart disease, commonly involving native or prosthetic valves. It frequently presents with univalvular involvement and simultaneous double valve or multivalvular involvement is rarely described. The third leading cause of infective endocarditis worldwide is Enterococcus faecalis, which is associated with high mortality rates despite important advances in antimicrobial therapy. It develops secondary to enterococcal bacteremia, with its origin from the gastrointestinal or genitourinary tract and predominantly affecting the elderly population with multiple comorbidities. Clinical presentation is usually less typical, and the treatment is challenging. It can be marked by antibiotic resistance, side effects, and subsequent complications. Surgical treatment can be considered if deemed appropriate. To the best of our knowledge, we present the first case-based narrative review of Enterococcus faecalis double valve endocarditis involving both the aortic native and prosthetic mitral valve, highlighting the clinical characteristics, treatment, and complications of this condition.<\/jats:p>","DOI":"10.3390\/jpm13020300","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T06:00:05Z","timestamp":1675836005000},"page":"300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Native and Prosthetic Simultaneously Double Valve Infective Endocarditis with Enterococcus faecalis\u2014Case-Based Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-5580","authenticated-orcid":false,"given":"Raluca","family":"Haliga","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-2360","authenticated-orcid":false,"given":"Victorita","family":"Sorodoc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Morarasu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adorata","family":"Coman","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Interdisciplinary Team Department, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0043-9051","authenticated-orcid":false,"given":"Alexandr","family":"Ceasovschih","sequence":"additional","affiliation":[{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-2356","authenticated-orcid":false,"given":"Oana","family":"Sirbu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-0645","authenticated-orcid":false,"given":"Catalina","family":"Lionte","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bologa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5024-3030","authenticated-orcid":false,"given":"Alexandra","family":"Stoica","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Constantin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Puha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidiu","family":"Petris","sequence":"additional","affiliation":[{"name":"2nd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"},{"name":"Nursing Department, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-1909","authenticated-orcid":false,"given":"Minerva","family":"Badescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"3rd Internal Medicine Clinic, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Crisu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Catana","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, \u201cSt. Spiridon\u201d Emergency Clinical County Hospital, 700111 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Haliga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine, \u201cGrigore T. 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Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2324709620936855","DOI":"10.1177\/2324709620936855","article-title":"Multivalvular Endocarditis Involving 3 Valves in a Nonsurgical Candidate","volume":"8","author":"Boyer","year":"2020","journal-title":"J. Investig. Med. High Impact Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0003-4975(01)02603-0","article-title":"Double Valve Endocarditis","volume":"71","author":"Gillinov","year":"2001","journal-title":"Ann. Thorac. Surg."},{"key":"ref_5","first-page":"18","article-title":"Double Valve Infective Endocarditis Presenting with Acute Ischemic Stroke","volume":"2","author":"Ugurlu","year":"2015","journal-title":"J. Cardiovasc. Med. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tomoaia, R., Oprea, A., Sandu, I., Danu, V., Pop, D., Zdrenghea, D., D\u0103d\u00e2rlat-Pop, A., Minciun\u0103, I.A., Che\u021ban, I.M., and Hada, N.C. (2022). A Rare Case of Successfully Treated Double Valve Infective Endocarditis Caused by Pseudomonas aeruginosa. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911127"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/cid\/ciy064","article-title":"A Review of Combination Antimicrobial Therapy for Enterococcus faecalis Bloodstream Infections and Infective Endocarditis","volume":"67","author":"Beganovic","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMcp2000400","article-title":"Native-Valve Infective Endocarditis","volume":"383","author":"Chambers","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00380-021-01980-2","article-title":"Double-valve infective endocarditis: Clinical features and prognostic impact-a retrospective study in a surgical centre","volume":"37","author":"Scheggi","year":"2022","journal-title":"Heart Vessels."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1532\/HSF98.2013280","article-title":"Surgical treatment of double valve endocarditis","volume":"17","author":"Tas","year":"2014","journal-title":"Heart Surg. Forum."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cjca.2020.03.046","article-title":"Characteristics and Prognosis of Patients With Left-Sided Native Bivalvular Infective Endocarditis","volume":"37","author":"Bohbot","year":"2021","journal-title":"Can. J. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"\u00c1lvarez-Zaballos, S., Gonz\u00e1lez-Ramallo, V., Quintana, E., Mu\u00f1oz, P., De la Villa-Mart\u00ednez, S., Fari\u00f1as, M.C., Arn\u00e1iz-de las Revillas, F., de Alarc\u00f3n, A., Rodr\u00edguez-Esteban, M.\u00c1., and Mir\u00f3, J.M. (2022). Multivalvular Endocarditis: A Rare Condition with Poor Prognosis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11164736"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","article-title":"2015 ESC Guidelines for the management of infective endocarditis","volume":"36","author":"Habib","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.carpath.2009.09.006","article-title":"Prosthetic valve endocarditis: Clinicopathological correlates in 122 surgical specimens from 116 patients (1985\u20132004)","volume":"20","author":"Lee","year":"2011","journal-title":"Cardiovasc Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0140-6736(15)00067-7","article-title":"Infective endocarditis","volume":"387","author":"Cahill","year":"2016","journal-title":"Lancet"},{"key":"ref_16","first-page":"e22522","article-title":"A Rarely Reported Case of Enterococcus faecalis Bacteremia Causing Infective Endocarditis and Osteomyelitis","volume":"14","author":"Devarakonda","year":"2022","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIRCULATIONAHA.112.001170","article-title":"Enterococcus faecalis Infective Endocarditis. A Pilot Study of the Relationship Between Duration of Gentamicin Treatment and Outcome","volume":"127","author":"Dahl","year":"2013","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.3390\/jcm10194594","article-title":"Ampicillin Plus Ceftriaxone Regimen against Enterococcus faecalis Endocarditis: A Literature Review","volume":"10","author":"Marino","year":"2021","journal-title":"J. Clin. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s10096-005-0007-9","article-title":"Enterococcal prosthetic valve infective endocarditis: Report of 45 episodes from the International Collaboration on Endocarditis-merged database","volume":"24","author":"Anderson","year":"2005","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.amjmed.2005.02.020","article-title":"Enterococcal endocarditis: 107 cases from the international collaboration on endocarditis merged database","volume":"118","author":"McDonald","year":"2005","journal-title":"Am. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.eimc.2009.02.007","article-title":"Enterococcal endocarditis: A multicenter study of 76 cases","volume":"27","year":"2009","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"03000605221112019","DOI":"10.1177\/03000605221112019","article-title":"Enterococcus faecalis-induced infective endocarditis: An unusual source of infection and a rare clinical presentation","volume":"50","author":"Seby","year":"2022","journal-title":"J. Int. Med. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1586\/14779072.2013.832482","article-title":"Enterococcus faecalis infective endocarditis: Focus on clinical aspects","volume":"11","author":"Dahl","year":"2013","journal-title":"Expert. Rev. Cardiovasc. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1128\/JCM.00635-17","article-title":"Laboratory Diagnosis of Infective Endocarditis","volume":"55","author":"Liesman","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2019.04.059","article-title":"Prevalence of Infective Endocarditis in Enterococcus faecalis Bacteremia","volume":"74","author":"Dahl","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s10096-021-04210-9","article-title":"Short time to blood culture positivity in Enterococcus faecalis infective endocarditis","volume":"40","author":"Oldberg","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.7861\/clinmed.cme.20.1.1","article-title":"Infective endocarditis: A contemporary update","volume":"20","author":"Rajani","year":"2020","journal-title":"Clin. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/hrt.2003.029868","article-title":"Echocardiography in infective endocarditis","volume":"90","author":"Evangelista","year":"2004","journal-title":"Heart"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/22221751.2021.1924865","article-title":"Microdiversity of Enterococcus faecalis isolates in cases of infective endocarditis: Selection of non-synonymous mutations and large deletions is associated with phenotypic modifications","volume":"10","author":"Royer","year":"2021","journal-title":"Emerg. Microbes. Infect."},{"key":"ref_30","first-page":"e72","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"574","DOI":"10.7326\/0003-4819-146-8-200704170-00008","article-title":"Brief communication: Treatment of Enterococcus faecalis endocarditis with ampicillin plus ceftriaxone","volume":"146","author":"Len","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/cid\/cit052","article-title":"Ampicillin plus ceftriaxone is as effective as ampicillin plus gentamicin for treating Enterococcus faecalis infective endocarditis","volume":"56","author":"Almirante","year":"2013","journal-title":"Clin. Infect Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000329842","article-title":"Once versus twice daily gentamicin dosing for infective E. faecalis infective endocarditis: Focus on clinical aspects","volume":"119","author":"Buchholtz","year":"2011","journal-title":"Cardiology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/00365540701534517","article-title":"Swedish guidelines for diagnosis and treatment of infective endocarditis","volume":"39","author":"Westling","year":"2007","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1086\/594122","article-title":"Severity of gentamicin\u2019s nephrotoxic effect on patients with infective endocarditis: A prospective observational cohort study of 373 patients","volume":"48","author":"Buchholtz","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s15010-019-01290-w","article-title":"Efficacy of teicoplanin monotherapy following initial standard therapy in Enterococcus faecalis infective endocarditis: A retrospective cohort study","volume":"47","author":"Sommet","year":"2019","journal-title":"Infection"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1086\/444459","article-title":"Endocarditis due to vancomycin-resistant enterococci: Case report and review of the literature","volume":"41","author":"Stevens","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/JCM.02188-06","article-title":"Vancomycin-resistant Enterococcus faecalis endocarditis: Linezolid failure and strain characterization of virulence factors","volume":"45","author":"Tsigrelis","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1086\/383472","article-title":"Daptomycin: Another novel agent for treating infections due to drug-resistant Gram-positive pathogens","volume":"38","author":"Carpenter","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/23744235.2020.1725109","article-title":"Clinical efficacy of amoxicillin\/clavulanate plus cefditoren as de-escalation combination therapy for endocarditis due to strongly biofilm-forming Enterococcus faecalis","volume":"52","author":"Attanasio","year":"2020","journal-title":"Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40264-016-0469-y","article-title":"Vancomycin-Induced Thrombocytopenia: A Narrative Review","volume":"40","author":"Mohammadi","year":"2017","journal-title":"Drug. Saf."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1590\/S1413-86702002000400007","article-title":"Uncommon vancomycin-induced side effects","volume":"6","author":"Rocha","year":"2002","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1182\/blood.V75.2.518.518","article-title":"Vancomycin-dependent antibodies associated with thrombocytopenia and refractoriness to platelet transfusion in patients with leukemia","volume":"75","author":"Christie","year":"1990","journal-title":"Blood"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"294","DOI":"10.5045\/kjh.2009.44.4.294","article-title":"A case of vancomycin-induced thrombocytopenia","volume":"44","author":"Lee","year":"2009","journal-title":"Korean J. Hematol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"358","DOI":"10.5414\/CP204215","article-title":"Imipenem cilastatin sodium-associated thrombocytopenia in an older patient: A case report and literature review","volume":"60","author":"Qiao","year":"2022","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0025-7753(01)72059-3","article-title":"Trombocitopenia aguda por imipenem\/cilastatina [Imipenem\/cilastatin-induced acute thrombocytopenia]","volume":"117","year":"2001","journal-title":"Med. Clin."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jacc.2020.05.049","article-title":"Early Surgery in Infective Endocarditis: Can it Be Too Early?","volume":"76","author":"Mack","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/hrt.2003.032128","article-title":"Infective endocarditis in Europe: Lessons from the Euro heart survey","volume":"91","author":"Tornos","year":"2005","journal-title":"Heart"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1001\/jamainternmed.2013.8203","article-title":"In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis","volume":"173","author":"Lalani","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.amjcard.2007.12.015","article-title":"Management of prosthetic valve infective endocarditis","volume":"101","author":"Hill","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/CIRCULATIONAHA.117.028783","article-title":"Prosthetic Valve Endocarditis After Surgical Aortic Valve Replacement","volume":"136","author":"Glaser","year":"2017","journal-title":"Circulation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0735-1097(03)00829-5","article-title":"A randomized trial of aspirin on the risk of embolic events in patients with infective endocarditis","volume":"42","author":"Chan","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jinf.2009.03.006","article-title":"Reduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid","volume":"58","author":"Eisen","year":"2009","journal-title":"J. Infect."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1086\/513197","article-title":"Impact of prior antiplatelet therapy on risk of embolism in infective endocarditis","volume":"44","author":"Anavekar","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1086\/524021","article-title":"Effect of long-term aspirin use on embolic events in infective endocarditis","volume":"46","author":"Chan","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/B978-0-7020-4086-3.00007-2","article-title":"Infective endocarditis","volume":"119","author":"Ferro","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11886-018-1043-2","article-title":"Infective Endocarditis: Update on Epidemiology, Outcomes, and Management","volume":"20","author":"Vincent","year":"2018","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10096-010-1063-3","article-title":"Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis","volume":"30","author":"Rasmussen","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1445-5994.2011.02580.x","article-title":"Prosthetic valve endocarditis: What is the evidence for anticoagulant therapy?","volume":"41","author":"Yau","year":"2011","journal-title":"Intern. Med. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/jth.14736","article-title":"Coagulation: At the heart of infective endocarditis","volume":"18","author":"Liesenborghs","year":"2020","journal-title":"J. Thromb. 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