{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:30:27Z","timestamp":1790429427775,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institutional Research funding of UMC Maribor","award":["IRP- 2021\/01-21"],"award-info":[{"award-number":["IRP- 2021\/01-21"]}]},{"name":"Institutional Research funding of UMC Maribor","award":["P3-0321"],"award-info":[{"award-number":["P3-0321"]}]},{"name":"Institutional Research funding of UMC Maribor","award":["J3-3069"],"award-info":[{"award-number":["J3-3069"]}]},{"name":"Institutional Research funding of UMC Maribor","award":["J3-4523"],"award-info":[{"award-number":["J3-4523"]}]},{"name":"Slovenian Research Agency","award":["IRP- 2021\/01-21"],"award-info":[{"award-number":["IRP- 2021\/01-21"]}]},{"name":"Slovenian Research Agency","award":["P3-0321"],"award-info":[{"award-number":["P3-0321"]}]},{"name":"Slovenian Research Agency","award":["J3-3069"],"award-info":[{"award-number":["J3-3069"]}]},{"name":"Slovenian Research Agency","award":["J3-4523"],"award-info":[{"award-number":["J3-4523"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The role of estrogens and progesterone in the development and progression of endometrial cancer is well-established, but there are very little data about the role of androgens. There are five different androgens produced in women: dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA), androstenedione (A4), testosterone (T) and dihydrotestosterone (DHT). The most potent hormones are T and DHT, the latter being mainly produced from T in peripheral tissues, including endometrium. Although they are considered to exert antiproliferative effects in many settings and the expression of their receptors is more often associated with a good prognosis in EC, it is still unknown in which specific settings androgens have carcinogenic or protective effects in EC.<\/jats:p>","DOI":"10.3390\/jpm13020341","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T02:52:56Z","timestamp":1676515976000},"page":"341","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["What Role do Androgens Play in Endometrial Cancer?"],"prefix":"10.3390","volume":"13","author":[{"given":"Petra","family":"Ma\u010dek","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Maribor, Taborska ul 8, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Molinari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Maribor, Taborska ul 8, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1384-9487","authenticated-orcid":false,"given":"Monika","family":"Sobo\u010dan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Maribor, Taborska ul 8, 2000 Maribor, Slovenia"},{"name":"Division of Gynecology and Perinatology, University Medical Centre Maribor, Ljubljanska ul 5, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3543-5920","authenticated-orcid":false,"given":"Jure","family":"Knez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Maribor, Taborska ul 8, 2000 Maribor, Slovenia"},{"name":"Division of Gynecology and Perinatology, University Medical Centre Maribor, Ljubljanska ul 5, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Neves, T.R., Correia, M.T., Serrado, M.A., Horta, M., Caetano, A.P., and Cunha, T.M. 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