{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:10:18Z","timestamp":1760123418701,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Vaccination remains the best strategy against coronavirus disease 2019 (COVID-19) in terms of prevention. The efficacy and safety of COVID-19 vaccines is supported by well-designed clinical trials that recruited many participants. It is well-known that vaccination is associated with local side effects related to the injection site, and mild, systemic side effects. However, there has been an increase in the occurrence of what is known as infrequent adverse effects in the population of vaccinated individuals in real life. We present the case of a 46-year-old woman with no past medical history, who presented with a sharp chest pain with deep inspiration, a few days after receiving the third dose of the Pfizer-BioNTech COVID-19 mRNA vaccine (BNT162b2). There is an association between the BNT16b2 vaccination and myocarditis, pericarditis, and even bilateral pleural effusions. To the best of our knowledge, this is the first report featuring a unilateral pleural effusion in a patient with no known past medical history, who did not develop cardiac involvement nor have any viral infection. The aim of our report is to inform health professionals of the possibility of encountering this rare adverse event in their daily practice, as the population of individuals who are receiving additional vaccine doses is increasing steadily.<\/jats:p>","DOI":"10.3390\/jpm13030391","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T02:03:26Z","timestamp":1677204206000},"page":"391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unilateral Pleural Effusion after Third Dose of BNT162b2 mRNA Vaccination: Case Report"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-6243","authenticated-orcid":false,"given":"Nikolaos K.","family":"Athanasiou","sequence":"first","affiliation":[{"name":"Pulmonary and Respiratory Failure Department, First ICU, Evangelismos Hospital, 106 76 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archontoula","family":"Antonoglou","sequence":"additional","affiliation":[{"name":"Pulmonary and Respiratory Failure Department, First ICU, Evangelismos Hospital, 106 76 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Pulmonary and Respiratory Failure Department, First ICU, Evangelismos Hospital, 106 76 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7306-713X","authenticated-orcid":false,"given":"Edison","family":"Jahaj","sequence":"additional","affiliation":[{"name":"Pulmonary and Respiratory Failure Department, First ICU, Evangelismos Hospital, 106 76 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-619X","authenticated-orcid":false,"given":"Paraskevi","family":"Katsaounou","sequence":"additional","affiliation":[{"name":"Pulmonary and Respiratory Failure Department, First ICU, Evangelismos Hospital, 106 76 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, October 24). Weekly Epidemiological Update on COVID-19. Available online: https:\/\/covid19.who.int\/---24.10.2022."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.2147\/IDR.S315727","article-title":"Overview of the Main Anti-SARS-CoV-2 Vaccines: Mechanism of Action, Efficacy and Safety","volume":"14","author":"Mascellino","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"ref_4","unstructured":"(2022, October 26). Fact Sheet for Healthcare Providers Administering Vaccine (Vaccination Providers): Emergency Use Authorization (EUA) of the Pfizer-BioNTech COVID-19 Vaccine to Prevent Coronavirus Disease 2019 (COVID-19). Food and Drug Administration, Available online: https:\/\/www.fda.gov\/media\/153714\/download."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e059223","DOI":"10.1136\/bmjopen-2021-059223","article-title":"Reports of myocarditis and pericarditis following mRNA COVID-19 vaccination: A systematic review of spontaneously reported data from the UK, Europe and the USA and of the scientific literature","volume":"12","author":"Lane","year":"2022","journal-title":"BMJ Open"},{"key":"ref_6","unstructured":"(2022, October 18). Updated Signal Assessment Report on Myocarditis, Pericarditis with Tozinameran (COVID-19 mRNA Vaccine (Nucleoside-Modified)-COMIRNATY). European Medicines Agency. 2 September 2021. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/prac-recommendation\/updated-signal-assessment-report-myocarditis-pericarditis-tozinameran-covid-19-mrna-vaccine_en.pdf."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e00941-20","DOI":"10.1128\/JCM.00941-20","article-title":"Performance characteristics of the Abbott architect SARS-CoV-2 IgG assay and Seroprevalence in Boise, Idaho","volume":"58","author":"Bryan","year":"2020","journal-title":"J. Clin. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"ii4","DOI":"10.1136\/thx.2010.136978","article-title":"Investigation of a unilateral pleural effusion in adults: British Thoracic Society Pleural Disease Guideline 2010","volume":"65","author":"Hooper","year":"2010","journal-title":"Thorax"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1056\/NEJMra1403503","article-title":"Pleural Disease","volume":"378","author":"Light","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/qjmed\/hcm032","article-title":"Differentiating between malignant and idiopathic pleural effusions: The value of diagnostic procedures","volume":"100","author":"Sanchez","year":"2007","journal-title":"QJM"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jmv.27301","article-title":"Prevalence and clinical outcomes of pleural effusion in COVID-19 patients: A systematic review and meta-analysis","volume":"94","author":"Rathore","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/ijcp.14123","article-title":"Pleural effusion as an indicator for the poor prognosis of COVID-19 patients","volume":"75","author":"Wei","year":"2021","journal-title":"Int. J. Clin. Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e200126","DOI":"10.1148\/ryct.2020200126","article-title":"Thin-Section Chest CT Imaging of COVID-19 Pneumonia: A Comparison Between Patients with Mild and Severe Disease","volume":"2","author":"Yu","year":"2020","journal-title":"Radiol. Cardiothorac. Imaging"},{"key":"ref_14","first-page":"15","article-title":"Polyserositis (pericarditis and bilateral pleural effusion) after COVID-19 mRNA vaccine","volume":"22","author":"Korzeniowska","year":"2022","journal-title":"Hematol. Clin. Pract."},{"key":"ref_15","first-page":"e24828","article-title":"An Unusual Case of Hemorrhagic Pleuropericarditis After COVID-19 Vaccination","volume":"14","author":"Javed","year":"2022","journal-title":"Cureus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/clc.23828","article-title":"Myocarditis after COVID-19 mRNA vaccination: A systematic review of case reports and case series","volume":"45","author":"Park","year":"2022","journal-title":"Clin. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jccase.2022.04.020","article-title":"A case of an elderly female who developed subacute pleuropericarditis following BNT162b2 mRNA COVID-19 vaccination","volume":"26","author":"Mizoguchi","year":"2022","journal-title":"J. Cardiol. Cases"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1002\/jmv.27036","article-title":"Herpes zoster emergence following mRNA COVID-19 vaccine","volume":"93","author":"Eid","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1684\/ejd.2018.3335","article-title":"Herpes zoster complicated by unilateral pleural effusion","volume":"28","author":"He","year":"2018","journal-title":"Eur. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e01026","DOI":"10.1002\/rcr2.1026","article-title":"IgG4 related pleural disease: Recurrent pleural effusion after COVID-19 vaccination","volume":"10","author":"Tasnim","year":"2022","journal-title":"Respirol. Case Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e246533","DOI":"10.1136\/bcr-2021-246533","article-title":"Marked increase of interferon-\u03b2 after BNT162b2 mRNA vaccination: A case of polyarthritis with pleurisy","volume":"15","author":"Shimagami","year":"2022","journal-title":"BMJ Case Rep."},{"key":"ref_22","first-page":"21","article-title":"Chest Pain","volume":"2","author":"Johnson","year":"2022","journal-title":"Encycl. Respir. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e13706","DOI":"10.1111\/eci.13706","article-title":"Estimate false-negative RT-PCR rates for SARS-CoV-2. A systematic review and meta-analysis","volume":"52","author":"Pecoraro","year":"2022","journal-title":"Eur. J. Clin. Investig."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/3\/391\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:40:37Z","timestamp":1760121637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/3\/391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["jpm13030391"],"URL":"https:\/\/doi.org\/10.3390\/jpm13030391","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2023,2,23]]}}}