{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:06:31Z","timestamp":1790996791313,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>We aimed to investigate high-order aberration (HOA) change between topography-guided (TG) and wavefront-optimized (WFO) laser in situ keratomileusis (LASIK) in patients with different degrees of myopia. A non-randomized clinical trial was conducted, in which 40 eyes of 20 patients aged 20\u201350 years old were included. Participants received TG-LASIK in one eye and WFO-LASIK on the alternate eye. Corneal topography and HOAs including coma, trefoil, spherical aberration (SA), and contrast sensitivity (CS) were collected. Moreover, a quality of vision (QoV) questionnaire was completed by each participant. Non-parametric tests were used to infer the difference in HOAs and CS between the TG-LASIK and WFO-LASIK groups, and subgroup analyses stratified by myopia degree were performed. The high-myopia patients with TG-LASIK showed more coma and SA compared to low-myopia individuals (all 95% CI lower limits &gt; 0), and subjects who received WFO-LASIK exhibited more SA in high-myopia status (both 95% CI lower limits &gt; 0). The TG-LASIK group showed lower postoperative trefoil compared to the WFO-LASIK group in the high-myopia population (mean difference: \u22120.1267, 95% CI: \u22120.24 to \u22120.01). The TG-LASIK group yielded less surgically induced haze, better clarity at night, and better total quality scores (all p &lt; 0.05). In conclusion, TG-LASIK might yield less postoperative trefoil in high-myopia patients and higher QoV in the general population compared to the WFO-LASIK procedure.<\/jats:p>","DOI":"10.3390\/jpm13030399","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:22:16Z","timestamp":1677464536000},"page":"399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Higher-Order Aberrations of Topography-Guided LASIK and Wavefront-Optimized LASIK in High- and Low-Myopic Eyes: A Non-Randomized Controlled Trial"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5291-8484","authenticated-orcid":false,"given":"Elsa Lin-Chin","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Optometry, MacKay Junior College of Medicine, Nursing, and Management, Taipei 11260, Taiwan"},{"name":"Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei 220216, Taiwan"},{"name":"Department of Optometry, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Kai","family":"Chang","sequence":"additional","affiliation":[{"name":"Nobel Eye Institute, Taipei 100008, Taiwan"},{"name":"Department of Optometry, Da-Yeh University, Changhua 515006, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-0488","authenticated-orcid":false,"given":"Chia-Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Nobel Eye Institute, Taipei 100008, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 402306, Taiwan"},{"name":"Department of Ophthalmology, Jen-Ai Hospital Dali Branch, Taichung 412224, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-6049","authenticated-orcid":false,"given":"Ie-Bin","family":"Lian","sequence":"additional","affiliation":[{"name":"Institute of Statistical and Information Science, National Changhua University of Education, Chunghua 50007, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-6407","authenticated-orcid":false,"given":"Chen-Cheng","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Optometry, MacKay Junior College of Medicine, Nursing, and Management, Taipei 11260, Taiwan"},{"name":"Nobel Eye Institute, Taipei 100008, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/cxo.12075","article-title":"Laser in situ keratomileusis in 2012: A review","volume":"97","author":"Sutton","year":"2014","journal-title":"Clin. 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