{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T01:40:02Z","timestamp":1768786802458,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: There is a growing body of evidence suggesting a link between obstructive sleep apnea (OSA) and atrial fibrillation (AF). The primary objective of this study is to evaluate the association between OSA and AF in acute ischemic stroke. The secondary objective is to describe the clinical features of patients with acute ischemic stroke and concomitant OSA. Methods: We enrolled consecutive patients with acute ischemic stroke. All patients underwent full-night cardiorespiratory polygraphy. To determine if there is an association between AF and OSA, we compared the observed frequency of this association with the expected frequency from a random co-occurrence of the two conditions. Subsequently, patients with and without OSA were compared. Results: A total of 174 patients were enrolled (mean age 67.3 \u00b1 11.6 years; 95 males). OSA and AF were present in 89 and 55 patients, respectively. The association OSA + AF was observed in 33\/174 cases, which was not statistically different compared to the expected co-occurrence of the two conditions. Patients with OSA showed a higher neck circumference and body mass index, a higher prevalence of hypertension and dysphagia, and a higher number of central apneas\/hypoapneas. In the multivariate analysis, dysphagia and hypertension were independent predictors of OSA. A positive correlation was observed between OSA severity, BMI, and neck circumference. The number of central apneas\/hypoapneas was positively correlated with stroke severity. Conclusions: Our data suggest that OSA and AF are highly prevalent but not associated in acute stroke. Our findings support the hypothesis that OSA acts as an independent risk factor for stroke.<\/jats:p>","DOI":"10.3390\/jpm13030527","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T05:53:44Z","timestamp":1678859624000},"page":"527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Obstructive Sleep Apnea and Atrial Fibrillation in Acute Ischemic Stroke: A Cross-Sectional Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-5353","authenticated-orcid":false,"given":"Valerio","family":"Brunetti","sequence":"first","affiliation":[{"name":"UOC Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy"},{"name":"Department of Neurosciences, Universit\u00e0 Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Testani","sequence":"additional","affiliation":[{"name":"Stroke Unit, Azienda Ospedaliera San Camillo, 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Losurdo","sequence":"additional","affiliation":[{"name":"Servizio di Neurologia e Neurofisiopatologia, Humanitas San Pio X, 20159 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catello","family":"Vollono","sequence":"additional","affiliation":[{"name":"UOC Neurofisiopatologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-9271","authenticated-orcid":false,"given":"Aldobrando","family":"Broccolini","sequence":"additional","affiliation":[{"name":"UOC Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy"},{"name":"Department of Neurosciences, Universit\u00e0 Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Di Iorio","sequence":"additional","affiliation":[{"name":"UOC Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1604-6594","authenticated-orcid":false,"given":"Giovanni","family":"Frisullo","sequence":"additional","affiliation":[{"name":"UOC Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-3916","authenticated-orcid":false,"given":"Fabio","family":"Pilato","sequence":"additional","affiliation":[{"name":"UOC Neurologia, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo, 200, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Profice","sequence":"additional","affiliation":[{"name":"UOC Neurologia and Stroke Unit, Mater Olbia Hospital, 07026 Olbia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Marotta","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Universit\u00e0 Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Rollo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Universit\u00e0 Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2370-840X","authenticated-orcid":false,"given":"Irene","family":"Scala","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Universit\u00e0 Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[{"name":"UOC Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy"},{"name":"Department of Neurosciences, Universit\u00e0 Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-799X","authenticated-orcid":false,"given":"Giacomo","family":"Della Marca","sequence":"additional","affiliation":[{"name":"UOC Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy"},{"name":"Department of Neurosciences, Universit\u00e0 Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","first-page":"1077","article-title":"The Sleep Heart Health Study: Design, rationale, and methods","volume":"20","author":"Quan","year":"1997","journal-title":"Sleep"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.15420\/aer.2015.4.1.14","article-title":"Obstructive Sleep Apnoea and Atrial Fibrillation","volume":"4","author":"Zhang","year":"2015","journal-title":"Arrhythmia Electrophysiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3389\/fneur.2017.00668","article-title":"The Interplay between Obstructive Sleep Apnea and Atrial Fibrillation","volume":"8","author":"Chaturvedi","year":"2017","journal-title":"Front. 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Dis."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/3\/527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:55:24Z","timestamp":1760122524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/3\/527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["jpm13030527"],"URL":"https:\/\/doi.org\/10.3390\/jpm13030527","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}