{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:40:30Z","timestamp":1790120430939,"version":"4.0.1"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Project of Hubei Province","award":["2022CFC022"],"award-info":[{"award-number":["2022CFC022"]}]},{"name":"Natural Science Foundation of Project of Hubei Province","award":["ZY2023F060"],"award-info":[{"award-number":["ZY2023F060"]}]},{"name":"Natural Science Foundation of Project of Hubei Province","award":["WG20M01"],"award-info":[{"award-number":["WG20M01"]}]},{"name":"Natural Science Foundation of Project of Hubei Province","award":["(2022)02049"],"award-info":[{"award-number":["(2022)02049"]}]},{"name":"Hubei Administration of Traditional Chinese Medicine","award":["2022CFC022"],"award-info":[{"award-number":["2022CFC022"]}]},{"name":"Hubei Administration of Traditional Chinese Medicine","award":["ZY2023F060"],"award-info":[{"award-number":["ZY2023F060"]}]},{"name":"Hubei Administration of Traditional Chinese Medicine","award":["WG20M01"],"award-info":[{"award-number":["WG20M01"]}]},{"name":"Hubei Administration of Traditional Chinese Medicine","award":["(2022)02049"],"award-info":[{"award-number":["(2022)02049"]}]},{"name":"Wuhan Municipal Health Commission","award":["2022CFC022"],"award-info":[{"award-number":["2022CFC022"]}]},{"name":"Wuhan Municipal Health Commission","award":["ZY2023F060"],"award-info":[{"award-number":["ZY2023F060"]}]},{"name":"Wuhan Municipal Health Commission","award":["WG20M01"],"award-info":[{"award-number":["WG20M01"]}]},{"name":"Wuhan Municipal Health Commission","award":["(2022)02049"],"award-info":[{"award-number":["(2022)02049"]}]},{"name":"China Plastic and Cosmetic Association","award":["2022CFC022"],"award-info":[{"award-number":["2022CFC022"]}]},{"name":"China Plastic and Cosmetic Association","award":["ZY2023F060"],"award-info":[{"award-number":["ZY2023F060"]}]},{"name":"China Plastic and Cosmetic Association","award":["WG20M01"],"award-info":[{"award-number":["WG20M01"]}]},{"name":"China Plastic and Cosmetic Association","award":["(2022)02049"],"award-info":[{"award-number":["(2022)02049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Purpose: This study aimed to investigate the value of combined detection of HCY and NRG4 in the diagnosis of early diabetic kidney disease (DKD) and to explore the association between the ratio of HCY\/NRG4 and DKD. Methods: A total of 140 diabetic patients and 43 healthy people were prospectively enrolled. The plasma HCY level, NRG4 level and HCY\/NRG4 of them were measured to compare their differences and analyze the correlation with DKD. The independent influencing factors of patients with DKD were screened, and the nomograph of DKD occurrence was constructed. Results: The levels of HCY and HCY\/NRG4 in diabetic patients were significantly increased, while the level of NRG4 was significantly decreased (p &lt; 0.01). The AUCs of HCY\/NRG4 predicted for DKD were 0.961. HCY\/NRG4 and the course of DM were independent risk factors for DKD. A predictive nomograph of DKD was constructed, and decision curve analysis (DCA) showed good clinical application value. HCY\/NRG4 was positively correlated with Scr, UACR, TG, UA, BUN, TCHOL and LDL and negatively correlated with eGFR and HDL (p &lt; 0.05). Conclusions: The level of HCY and NRG4 is closely related to the severity of DM, and combined detection of HCY\/NRG4 can identify patients with DKD at an early stage.<\/jats:p>","DOI":"10.3390\/jpm13030556","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T06:48:35Z","timestamp":1679294915000},"page":"556","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Value of the Combined Measurement of Serum HCY and NRG4 in Type 2 Diabetes Mellitus with Early Complicating Diabetic Nephropathy"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-5389","authenticated-orcid":false,"given":"Sheng","family":"Ding","sequence":"first","affiliation":[{"name":"The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan 430070, China"},{"name":"Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Wuhan Hospital, Wuhan 430022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Physical Examination, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Xu","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Cheng","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan 430070, China"},{"name":"Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuding","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangda","family":"Xiang","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China"},{"name":"Department of Endocrinology, General Hospital of Central Theater Command, Wuluo Road 627, Wuhan 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, May 25). 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Syndr."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/3\/556\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:20Z","timestamp":1760122760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/3\/556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["jpm13030556"],"URL":"https:\/\/doi.org\/10.3390\/jpm13030556","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,20]]}}}