{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:03:54Z","timestamp":1760148234792,"version":"build-2065373602"},"reference-count":15,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Aims: There is little evidence guiding the choice between a one-stent and a two-stent approach in unprotected distal left main coronary artery disease (UDLMCAD) presenting as acute coronary syndrome (ACS). We aim to compare these two techniques in an unselected ACS group. Methods and results: We conducted a single center retrospective observational study, that included all patients with UDLMCAD and ACS undergoing PCI between 2014 and 2018. Group A underwent PCI with a one-stent technique (n = 41, 58.6%), Group B with a two-stent technique (n = 29, 41.4%). A total of 70 patients were included, with a median age of 63 years, including n = 12 (17.1%) with cardiogenic shock. There were no differences between Group A and B in terms of patient characteristics, including SYNTAX score (median 23). The 30-day mortality was 15.7% overall, and was lower in Group B (3.5% vs. 24.4%, p = 0.02). Mortality rate at 4 years was significantly lower in Group B (21.4% vs. 44%), also when adjusted in a multivariable regression model (HR 0.26, p = 0.01). Conclusions: In our study, patients with UDLMCAD and ACS undergoing PCI using a two-stent technique had lower early and midterm mortality compared to one-stent approach, even after adjusting for patient-related or angiographic factors.<\/jats:p>","DOI":"10.3390\/jpm13040670","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T02:26:02Z","timestamp":1681698362000},"page":"670","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unprotected Left Main Bifurcation Stenting in Acute Coronary Syndromes: Two-Stent Technique versus One-Stent Technique"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2835-1665","authenticated-orcid":false,"given":"Lucian","family":"Predescu","sequence":"first","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"},{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marin","family":"Postu","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucian","family":"Zarma","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Bucsa","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Platon","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"},{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Croitoru","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Mereuta","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"},{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Licheardopol","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tulcea County Hospital, 820195 Tulcea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Predescu","sequence":"additional","affiliation":[{"name":"Doppler Clinic, 030136 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Dorobantu","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"},{"name":"Faculty of Health Sciences, University of Bristol, Bristol BS8 1QU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Deleanu","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cProf. CC Iliescu\u201d Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.4244\/EIJ-D-17-00622","article-title":"Percutaneous coronary intervention for the left main stem and other bifurcation lesions: 12th consensus document from the European Bifurcation Club","volume":"13","author":"Lassen","year":"2018","journal-title":"EuroIntervention"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1093\/eurheartj\/ehp353","article-title":"Unprotected left main revascularization in patients with acute coronary syndromes","volume":"30","author":"Montalescot","year":"2009","journal-title":"Eur. 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Dis., 8.","DOI":"10.3390\/jcdd8110155"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/4\/670\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:16:40Z","timestamp":1760123800000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/4\/670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,16]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["jpm13040670"],"URL":"https:\/\/doi.org\/10.3390\/jpm13040670","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2023,4,16]]}}}