{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:14:40Z","timestamp":1782393280971,"version":"3.54.5"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Nasal polyps (NPs) are rarely reported in childhood and usually represent red flags for systemic diseases, such as cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and immunodeficiencies. The European Position Paper released in 2020 (EPOS 2020) provided a detailed classification and defined the correct diagnostic and therapeutic approaches. We report a one-year experience of a multidisciplinary team, made up of otorhinolaryngologists, allergists, pediatricians, pneumologists and geneticists, with the aim of ensuring a personalized diagnostic and therapeutic management of the pathology. In 16 months of activity, 53 patients were admitted (25 children with chronic rhinosinusitis with polyposis and 28 with antro-choanal polyp). All patients underwent phenotypic and endo-typic assessment, using proper classification tools for nasal pathology (both endoscopic and radiological), as well as adequate cytological definition. An immuno\u2013allergic evaluation was carried out. Pneumologists evaluated any lower airway respiratory disease. Genetic investigations concluded the diagnostic investigation. Our experience enhanced the complexity of children\u2019s NPs. A multidisciplinary assessment is mandatory for a targeted diagnostic and therapeutic pathway.<\/jats:p>","DOI":"10.3390\/jpm13050707","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T03:38:07Z","timestamp":1682307487000},"page":"707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Endotypes of Nasal Polyps in Children: A Multidisciplinary Approach"],"prefix":"10.3390","volume":"13","author":[{"given":"Emanuela","family":"Sitzia","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Children\u2019s Hospital \u201cOspedale Pediatrico Bambino Ges\u00f9\u2014IRCCS\u201d, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Santarsiero","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Children\u2019s Hospital \u201cOspedale Pediatrico Bambino Ges\u00f9\u2014IRCCS\u201d, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Marini","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Children\u2019s Hospital \u201cOspedale Pediatrico Bambino Ges\u00f9\u2014IRCCS\u201d, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Majo","sequence":"additional","affiliation":[{"name":"Department of Cystic Fibrosis, Children\u2019s Hospital \u201cOspedale Pediatrico Bambino Ges\u00f9\u2014IRCCS\u201d, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"De Vincentiis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, University \u201cUniversit\u00e0 Degli Studi Tor Vergata di Roma\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cristalli","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Children\u2019s Hospital \u201cOspedale Pediatrico Bambino Ges\u00f9\u2014IRCCS\u201d, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Artesani","sequence":"additional","affiliation":[{"name":"Department of Allergology, Children\u2019s Hospital \u201cOspedale Pediatrico Bambino Ges\u00f9\u2014IRCCS\u201d, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro Giovanni","family":"Fiocchi","sequence":"additional","affiliation":[{"name":"Department of Allergology, Children\u2019s Hospital \u201cOspedale Pediatrico Bambino Ges\u00f9\u2014IRCCS\u201d, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11882-018-0792-8","article-title":"Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management","volume":"18","author":"Heath","year":"2018","journal-title":"Curr. 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