{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:00:49Z","timestamp":1775818849505,"version":"3.50.1"},"reference-count":198,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Cerebral cavernous malformations (CCMs) arise when capillaries within the brain enlarge abnormally, causing the blood\u2013brain barrier (BBB) to break down. The BBB serves as a sophisticated interface that controls molecular interactions between the bloodstream and the central nervous system. The neurovascular unit (NVU) is a complex structure made up of neurons, astrocytes, endothelial cells (ECs), pericytes, microglia, and basement membranes, which work together to maintain blood\u2013brain barrier (BBB) permeability. Within the NVU, tight junctions (TJs) and adherens junctions (AJs) between endothelial cells play a critical role in regulating the permeability of the BBB. Disruptions to these junctions can compromise the BBB, potentially leading to a hemorrhagic stroke. Understanding the molecular signaling cascades that regulate BBB permeability through EC junctions is, therefore, essential. New research has demonstrated that steroids, including estrogens (ESTs), glucocorticoids (GCs), and metabolites\/derivatives of progesterone (PRGs), have multifaceted effects on blood\u2013brain barrier (BBB) permeability by regulating the expression of tight junctions (TJs) and adherens junctions (AJs). They also have anti-inflammatory effects on blood vessels. PRGs, in particular, have been found to play a significant role in maintaining BBB integrity. PRGs act through a combination of its classic and non-classic PRG receptors (nPR\/mPR), which are part of a signaling network known as the CCM signaling complex (CSC). This network couples both nPR and mPR in the CmPn\/CmP pathway in endothelial cells (ECs).<\/jats:p>","DOI":"10.3390\/jpm13050751","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T02:27:56Z","timestamp":1682648876000},"page":"751","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["CmPn\/CmP Signaling Networks in the Maintenance of the Blood Vessel Barrier"],"prefix":"10.3390","volume":"13","author":[{"given":"Revathi","family":"Gnanasekaran","sequence":"first","affiliation":[{"name":"Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Aickareth","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majd","family":"Hawwar","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nickolas","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7892-0534","authenticated-orcid":false,"given":"Jacob","family":"Croft","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4379-3616","authenticated-orcid":false,"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine (MTM), Texas Tech University Health Science Center El Paso, El Paso, TX 79905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.20517\/2574-1209.2018.34","article-title":"Recent advances in cerebral cavernous malformation research","volume":"2","author":"Padarti","year":"2018","journal-title":"Vessel Plus"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Rigamonti, D. 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