{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:38:35Z","timestamp":1769049515479,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T00:00:00Z","timestamp":1682726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>(1) Background: In head and neck squamous cell carcinoma, tumor hypoxia has been associated with radio\/chemoresistance and poor prognosis, whereas human papillomavirus (HPV)-positive status has a positive impact on treatment response and survival outcomes. The aim of this study was to evaluate the expression and the potential prognostic value of hypoxia-induced endogenous markers in patients treated for squamous cell carcinoma of the nasal cavity and paranasal sinuses (SNSCC), and their correlation with HPV status. (2) Methods: In this monocentric study, patients treated in a curative intent for a SNSCC were screened retrospectively. Protein expression of CA-IX, GLUT-1, VEGF, VEGF-R1, and HIF-1\u03b1 was determined by immunohistochemical staining, scored, and then correlated with overall survival (OS) and locoregional recurrence free survival (LRRFS). HPV status was assessed and correlated with hypoxic markers. (3) Results: 40 patients were included. A strong expression of CA-IX, GLUT-1, VEGF, and VEGF-R1 was detected in 30%, 32.5%, 50%, and 37.5% of cases, respectively. HIF-1\u03b1 was detected in 27.5% of cases. High CA-IX expression was associated in univariate analysis with poor OS (p = 0.035), but there was no significant association between GLUT-1, VEGF, VEGF-R1, and HIF-1\u03b1 expression, and OS\/LRRFS. There was no correlation found between HPV status and hypoxia-induced endogenous markers (all p &gt; 0.05). (4) Conclusions: This study provides data on the expression of hypoxia-induced endogenous markers in patients treated for SNSCC and underlines the potential role of CA-IX as a prognostic biomarker for SNSCC.<\/jats:p>","DOI":"10.3390\/jpm13050767","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T13:54:46Z","timestamp":1682949286000},"page":"767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression, Prognostic Value and Correlation with HPV Status of Hypoxia-Induced Markers in Sinonasal Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-4908","authenticated-orcid":false,"given":"Alessandro","family":"Vinciguerra","sequence":"first","affiliation":[{"name":"Otorhinolaryngology and Skull Base Center, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Bedarida","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Skull Base Center, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"},{"name":"Centre de Ressources Biologiques Biobank Lariboisi\u00e8re (BB-0033-00064), DMU BioGem, AP-HP, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-2752","authenticated-orcid":false,"given":"Charlotte","family":"Pronier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Rennes, CHU Rennes, Virology, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) UMR_S 1085, F-35000 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"El Zein","sequence":"additional","affiliation":[{"name":"Pathology Department, Institut Curie, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Wassef","sequence":"additional","affiliation":[{"name":"Pathology Department, DMU DREAM, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-1119","authenticated-orcid":false,"given":"Sarah","family":"Atallah","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Skull Base Center, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-339X","authenticated-orcid":false,"given":"Florian","family":"Chatelet","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Skull Base Center, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75010 Paris, France"},{"name":"INSERM UMR 1153 ECSTRRA Team, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joffrey","family":"Molher","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Skull Base Center, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Manivet","sequence":"additional","affiliation":[{"name":"Centre de Ressources Biologiques Biobank Lariboisi\u00e8re (BB-0033-00064), DMU BioGem, AP-HP, 75010 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75010 Paris, France"},{"name":"INSERM U1141 NeuroDiderot, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Herman","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Skull Base Center, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75010 Paris, France"},{"name":"INSERM U1141 NeuroDiderot, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homa","family":"Adle-Biassette","sequence":"additional","affiliation":[{"name":"Pathology Department, DMU DREAM, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75010 Paris, France"},{"name":"INSERM U1141 NeuroDiderot, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Verillaud","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Skull Base Center, AP-HP, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75010 Paris, France"},{"name":"INSERM U1141 NeuroDiderot, 75010 Paris, 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