{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:01:59Z","timestamp":1788328919452,"version":"build-2803163510"},"reference-count":20,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Obstructive sleep apnea (OSA) increases the risk of stroke and cardiovascular diseases. However, its impact on geriatric patients with a prior history of stroke\/transient ischemic attack (TIA) has not been adequately studied. Methods: We utilized the 2019 National Inpatient Sample in the US to identify geriatric patients with OSA (G-OSA) who had a prior history of stroke\/TIA. We then compared subsequent stroke (SS) rates among sex and race subgroups. We also compared the demographics and comorbidities of SS+ and SS\u2212 groups and utilized logistic regression models to assess outcomes. Results: Out of 133,545 G-OSA patients admitted with a prior history of stroke\/TIA, 4.9% (6520) had SS. Males had a higher prevalence of SS, while Asian-Pacific Islanders and Native Americans had the highest prevalence of SS, followed by Whites, Blacks, and Hispanics. The SS+ group had higher all-cause in-hospital mortality rates, with Hispanics showing the highest rate compared to Whites and Blacks (10.6% vs. 4.9% vs. 4.4%, p &lt; 0.001), respectively. Adjusted analysis for covariates showed that complicated and uncomplicated hypertension (aOR 2.17 [95% CI 1.78\u20132.64]; 3.18 [95% CI 2.58\u20133.92]), diabetes with chronic complications (aOR 1.28 [95% CI 1.08\u20131.51]), hyperlipidemia (aOR 1.24 [95% CI 1.08\u20131.43]), and thyroid disorders (aOR 1.69 [95% CI 1.14\u20132.49]) were independent predictors of SS. The SS+ group had fewer routine discharges and higher healthcare costs. Conclusions: Our study shows that about 5% of G-OSA patients with a prior history of stroke\/TIA are at risk of hospitalization due to SS, which is associated with higher mortality and healthcare utilization. Complicated and uncomplicated hypertension, diabetes with chronic complications, hyperlipidemia, thyroid disorders, and admission to rural hospitals predict subsequent stroke.<\/jats:p>","DOI":"10.3390\/jpm13050782","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T13:54:46Z","timestamp":1682949286000},"page":"782","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recurrent\/Subsequent Stroke and Associated Outcomes in Geriatric Patients with OSA and Prior Stroke Events: A Retrospective Study Using the 2019 National Inpatient Sample"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-6426","authenticated-orcid":false,"given":"Rupak","family":"Desai","sequence":"first","affiliation":[{"name":"Division of Cardiology, Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital of North Midlands NHS Foundation Trust, Stoke-on-Trent ST4 6QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4372-1985","authenticated-orcid":false,"given":"Sai Priyanka","family":"Mellacheruvu","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Massachusetts, Lowell, MA 01854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-6459","authenticated-orcid":false,"given":"Adil Sarvar","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshni","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of General Medicine, GMERS Medical College, Gotri, Vadodara 390021, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayodya","family":"Perera","sequence":"additional","affiliation":[{"name":"International Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata Akhil","family":"Makarla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mamata Medical College, Khammam 507002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarayu","family":"Santhosh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Adichunchanagiri Institute of Medical Sciences, Rajiv Gandhi University of Health Sciences, B.G. Nagara, Bengaluru 560041, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneeb Ali","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine, William Carey University, Hattiesburg, MS 39401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal Khan","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaki Ur Rahman","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sanford Health, Fargo, ND 58102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wyoming Valley Medical Center, Wilkes-Barre, PA 18711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-4120","authenticated-orcid":false,"given":"Ankit","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Baptist Hospitals Of Southeast Texas, Beaumont, TX 77701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-4246","authenticated-orcid":false,"given":"Akhil","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mercy Catholic Medical Center, Darby, PA 19153, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-6247","authenticated-orcid":false,"given":"Rajesh","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA"},{"name":"Division of Cardiology, Emory University School of Medicine, Atlanta VA Medical Center, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.sleep.2023.02.019","article-title":"Post-stroke sleep disturbance and recurrent cardiovascular and cerebrovascular events: A systematic review and meta-analysis","volume":"104","author":"Hale","year":"2023","journal-title":"Sleep Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.sleep.2022.08.024","article-title":"Screening for OSA in stroke patients: The role of a sleep educator","volume":"100","author":"Sanchez","year":"2022","journal-title":"Sleep Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/1747493020903979","article-title":"Sleep for Stroke Management and Recovery Trial (Sleep SMART): Rationale and methods","volume":"15","author":"Brown","year":"2020","journal-title":"Int. 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