{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T22:11:41Z","timestamp":1766441501958,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Adelaide Kwok Paul Lee Bequest","award":["350-75131603","340-13133234"],"award-info":[{"award-number":["350-75131603","340-13133234"]}]},{"name":"FHMS Early Development Grant","award":["350-75131603","340-13133234"],"award-info":[{"award-number":["350-75131603","340-13133234"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Objective. To investigate the influence of endogenous and exogenous neuroendocrine analogues on the range and motion of jaw movement, mandibular growth, and factors affecting condylar guidance in patients with temporomandibular joint disorders using clinical assessment and radiographic imaging. Material and Methods. Eligible articles were extracted from eleven databases in early 2023 and screened following PRISMA protocols. Certainty of evidence and potential biases were assessed using the GRADE approach. Results. Nineteen articles were screened, with four deemed to be of high quality, eight of moderate quality, and the remaining seven of low to very low quality. Corticosteroids improve maximal incisal opening but not TMJ disorder symptoms. Higher doses worsen jaw movement and cause osseous deformity. Growth hormone affects occlusal development, and delayed treatment affects arch width. Sex hormone correlation with TMJ disorder is complex, with some studies showing a correlation between menstrual cycle phases and pain\/limited mobility. Conclusions. The evaluation of neuroendocrine influencers in relation to jaw movement in patients with temporomandibular joint disorders involves the complex interplay of potentially confounding factors that each require careful consideration to ensure accurate diagnoses and evaluations.<\/jats:p>","DOI":"10.3390\/jpm13050840","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:04:05Z","timestamp":1684289045000},"page":"840","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neuroendocrine Influencers and Associated Factors That Shape Jaw Movement and Growth in Temporomandibular Joint Disorder Management: A Systematic Review of Clinical and Radiographic Evidence"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-1572","authenticated-orcid":false,"given":"Taseef Hasan","family":"Farook","sequence":"first","affiliation":[{"name":"Adelaide Dental School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2004-0531","authenticated-orcid":false,"given":"James","family":"Dudley","sequence":"additional","affiliation":[{"name":"Adelaide Dental School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/joor.12531","article-title":"Temporomandibular disorders and dental occlusion. A systematic review of association studies: End of an era?","volume":"44","author":"Manfredini","year":"2017","journal-title":"J. Oral. Rehabil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00784-022-04835-w","article-title":"Variables influencing the device-dependent approaches in digitally analysing jaw movement\u2014A systematic review","volume":"27","author":"Farook","year":"2022","journal-title":"Clin. Oral. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0022-3913(78)80103-6","article-title":"Characteristics of the condylar path in internal derangements of the TMJ","volume":"39","author":"Farrar","year":"1978","journal-title":"J. Prosthet. Dent."},{"key":"ref_4","first-page":"181","article-title":"Topical review: New insights into the pathology and diagnosis of disorders of the temporomandibular joint","volume":"18","author":"Lobbezoo","year":"2004","journal-title":"J. Orofac. Pain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/bs.ctdb.2015.07.008","article-title":"Genetic influences on temporomandibular joint development and growth","volume":"115","author":"Hinton","year":"2015","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.archoralbio.2013.03.018","article-title":"Effects of growth hormone and ultrasound on mandibular growth in rats: microCT and toxicity analyses","volume":"58","author":"Khan","year":"2013","journal-title":"Arch. Oral. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/ijos.2015.47","article-title":"Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth","volume":"8","author":"Abbassy","year":"2016","journal-title":"Int. J. Oral. Sci."},{"key":"ref_8","first-page":"012085","article-title":"Molecular genetics and epigenetics of temporomandibular disorder","volume":"1943","author":"Antolis","year":"2021","journal-title":"J. Phys: Conf. Ser."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41368-021-00129-1","article-title":"A comprehensive review on biomarkers associated with painful temporomandibular disorders","volume":"13","author":"Shrivastava","year":"2021","journal-title":"Int. J. Oral. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/joor.13440","article-title":"Automation and deep (machine) learning in temporomandibular joint disorder radiomics. A systematic review","volume":"50","author":"Farook","year":"2023","journal-title":"J. Oral. Rehabil."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Chen, Y., Wang, J., Li, Y., Li, L., Luo, N., Wu, Y., Dai, H., and Zhou, J. (2022). Age-related variations in position and morphology of the temporomandibular joint in individuals with anterior openbite and crossbite: A multi-cross-sectional comparative study. BMC Oral. Health, 22.","DOI":"10.1186\/s12903-022-02236-9"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/joor.12480","article-title":"The role of molecular pain biomarkers in temporomandibular joint internal derangement","volume":"44","author":"Ernberg","year":"2017","journal-title":"J. Oral. Rehabil."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13005-021-00291-1","article-title":"Condylar erosion is predictive of painful closed lock of the temporomandibular joint: A magnetic resonance imaging study","volume":"17","author":"Emshoff","year":"2021","journal-title":"Head Face Med."},{"key":"ref_14","unstructured":"Piancino, M.G., Cannavale, R., Dalmasso, P., Tonni, I., Filipello, F., Perillo, L., Cattalini, M., and Meini, A. (2015). Seminars in Arthritis and Rheumatism, Elsevier."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.joms.2016.08.027","article-title":"Is there an association between temporomandibular joint effusion and arthralgia?","volume":"75","author":"Khawaja","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e422","DOI":"10.1097\/SCS.0000000000003627","article-title":"Genetic factors involved in mandibular prognathism","volume":"28","author":"Nelke","year":"2017","journal-title":"J. Craniofacial Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.yhbeh.2015.03.006","article-title":"The face of female dominance: Women with dominant faces have lower cortisol","volume":"71","author":"Wheatley","year":"2015","journal-title":"Horm. Behav."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.2147\/JPR.S311974","article-title":"How Well Do Current Laboratory Biomarkers Inform Clinical Decision-Making in Chronic Pain Management?","volume":"14","author":"Hagedorn","year":"2021","journal-title":"J. Pain Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM198008213030806","article-title":"Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system","volume":"303","author":"Cryer","year":"1980","journal-title":"New Engl. J. Med."},{"key":"ref_20","first-page":"742","article-title":"Conventional and functional imaging in the evaluation of temporomandibular joint rheumatoid arthritis: A systematic review","volume":"50","author":"Mupparapu","year":"2019","journal-title":"Quintessence Int."},{"key":"ref_21","unstructured":"Stoustrup, P., Kristensen, K.D., Verna, C., K\u00fcseler, A., Pedersen, T.K., and Herlin, T. (2013). Seminars in Arthritis and Rheumatism, Elsevier."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.sleep.2020.09.008","article-title":"Obstructive sleep Apnea\u2019s association with the cervical spine abnormalities, posture, and pain: A systematic review","volume":"75","author":"Pham","year":"2020","journal-title":"Sleep Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1179\/crn.2012.020","article-title":"New approaches to dental occlusion: A literature update","volume":"30","author":"Franco","year":"2012","journal-title":"CRANIO\u00ae"},{"key":"ref_24","first-page":"1","article-title":"Pharmacotherapy in temporomandibular disorders: A review","volume":"83","author":"Ouanounou","year":"2017","journal-title":"J. Can Dent. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1016\/j.joms.2011.05.026","article-title":"Female predominance and effect of gender on unilateral condylar hyperplasia: A review and meta-analysis","volume":"70","author":"Raijmakers","year":"2012","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10266-019-00439-1","article-title":"Estrogen signaling impacts temporomandibular joint and periodontal disease pathology","volume":"108","author":"Robinson","year":"2020","journal-title":"Odontology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/jgs.15354","article-title":"Temporomandibular joint disorders in older adults","volume":"66","author":"Yadav","year":"2018","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.oooo.2020.11.010","article-title":"Association of estrogen receptor alpha 1 and TMJ dysfunction: A pilot study","volume":"131","author":"Doetzer","year":"2021","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"727628","DOI":"10.3389\/fendo.2021.727628","article-title":"Common Pitfalls in the Interpretation of Endocrine Tests","volume":"12","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/01.NAJ.0000446779.99522.f6","article-title":"Constructing a search strategy and searching for evidence","volume":"114","author":"Aromataris","year":"2014","journal-title":"Am. J. Nurs."},{"key":"ref_31","first-page":"1","article-title":"Plagiarism in dentistry\u2014A systematic review","volume":"20","author":"Farook","year":"2020","journal-title":"Br. Dent. J. Oct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3899\/jrheum.141502","article-title":"Magnetic resonance imaging assessment of temporomandibular joint involvement and mandibular growth following corticosteroid injection in juvenile idiopathic arthritis","volume":"42","author":"Saurenmann","year":"2015","journal-title":"J. Rheumatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1016\/j.tripleo.2007.08.024","article-title":"Injection of sodium hyaluronate compared to a corticosteroid in the treatment of patients with temporomandibular joint osteoarthritis: A CT evaluation","volume":"105","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1530\/EJE-09-0694","article-title":"Influence of disease control with pegvisomant on sleep apnoea and tongue volume in patients with active acromegaly","volume":"161","author":"Berg","year":"2009","journal-title":"Eur. J. Endocrinol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.joms.2009.04.056","article-title":"Endogenous glutamate in association with inflammatory and hormonal factors modulates bone tissue resorption of the temporomandibular joint in patients with early rheumatoid arthritis","volume":"67","author":"Hajati","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12969-020-00464-3","article-title":"Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: A Norwegian 2-year prospective multicenter pilot study","volume":"18","author":"Frid","year":"2020","journal-title":"Pediatr. Rheumatol."},{"key":"ref_37","first-page":"1157","article-title":"Intraarticular corticosteroid injections of the temporomandibular joint in juvenile idiopathic arthritis","volume":"35","author":"Ringold","year":"2008","journal-title":"J. Rheumatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.joms.2011.11.003","article-title":"Intra-articular corticosteroid injections to the temporomandibular joints are safe and appear to be effective therapy in children with juvenile idiopathic arthritis","volume":"70","author":"Stoll","year":"2012","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_39","first-page":"e351","article-title":"A comparison of the effects of Methylprednisolone Acetate, Sodium Hyaluronate and Tenoxicam in the treatment of non-reducing disc displacement of the temporomandibular joint","volume":"23","year":"2018","journal-title":"Med. Oral. Patol. Oral. Cir. Bucal."},{"key":"ref_40","first-page":"293","article-title":"Arch dimensional changes in children with idiopathic short stature treated with recombinant growth hormone: A five-year study","volume":"65","author":"Richey","year":"1995","journal-title":"Angle Orthod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.ajodo.2011.12.021","article-title":"Prospective longitudinal evaluation of the relationship between changes in mandibular length and blood-spot IGF-1 measurements","volume":"141","author":"Masoud","year":"2012","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/00004728-200105000-00023","article-title":"Temporomandibular disorders: MR assessment of inflammatory changes in the posterior disk attachment during the menstrual cycle","volume":"25","author":"Suenaga","year":"2001","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.joms.2018.09.012","article-title":"Leptin levels in the synovial fluid of patients with temporomandibular disorders","volume":"77","author":"Xiong","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.joms.2017.12.030","article-title":"Benefit of temporomandibular joint lavage with intra-articular steroids versus lavage alone in the management of temporomandibular joint involvement in juvenile idiopathic arthritis","volume":"76","author":"Antonarakis","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1002\/art.21384","article-title":"Utility of corticosteroid injection for temporomandibular arthritis in children with juvenile idiopathic arthritis","volume":"52","author":"Arabshahi","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1007\/s00784-022-04667-8","article-title":"Association between sexual maturation and anterior disc displacement of temporomandibular joint in adolescents aged 13\u201314 years","volume":"26","author":"Shen","year":"2022","journal-title":"Clin. Oral. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.joms.2011.09.013","article-title":"Increased \u03b2-endorphin levels and generalized decreased pain thresholds in patients with limited jaw opening and movement-evoked pain from the temporomandibular joint","volume":"70","author":"Feldreich","year":"2012","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.17116\/stomat201594629-31","article-title":"Features of the hormonal status in patients with temporomandibular joint dysfunction and class II malocclusion","volume":"94","author":"Gus","year":"2015","journal-title":"Stomatologiia"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Leszczyszyn, A., Hnitecka, S., and Dominiak, M. (2021). Could Vitamin D3 Deficiency Influence Malocclusion Development?. Nutrients, 13.","DOI":"10.3390\/nu13062122"},{"key":"ref_50","first-page":"41","article-title":"Elevated Levels of \u03b2-Endorphin in Temporomandibular Joint Synovial Lavage Fluid of Patients with Closed Lock","volume":"19","author":"Kajii","year":"2005","journal-title":"J. Orofac. Pain"},{"key":"ref_51","first-page":"290","article-title":"Inflammatory markers in temporomandibular joint disorders","volume":"37","author":"Jurkowski","year":"2012","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/clr.13137","article-title":"Medication-related dental implant failure: Systematic review and meta-analysis","volume":"29","author":"Chappuis","year":"2018","journal-title":"Clin. Oral. Implants Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1111\/adj.12593","article-title":"Management of temporomandibular joint disorders: A surgeon\u2019s perspective","volume":"63","author":"Dimitroulis","year":"2018","journal-title":"Aust. Dent. J."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/5\/840\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:36:20Z","timestamp":1760124980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/5\/840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jpm13050840"],"URL":"https:\/\/doi.org\/10.3390\/jpm13050840","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}