{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:08:55Z","timestamp":1790845735571,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014840","name":"The Federal Joint Committee, Innovation Committee","doi-asserted-by":"publisher","award":["01VSF18051"],"award-info":[{"award-number":["01VSF18051"]}],"id":[{"id":"10.13039\/501100014840","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Depression and anxiety (DA) are common mental disorders in patients with chronic diseases, but the research regarding their prevalence in heart transplantation (HTx) is still limited. Methods: We performed an analysis of the prevalence and prognostic relevance of DA in patients who underwent HTx between 2010 and 2018 in Germany. Data were obtained from Allgemeine Ortskrankenkasse (AOK), which is the largest public health insurance provider. Results: Overall, 694 patients were identified. More than a third of them were diagnosed with DA before undergoing HTx (n = 260, 37.5%). Patients with DA more often had an ischaemic cardiomyopathy (p &lt; 0.001) and a history of previous myocardial infarction (p = 0.001) or stroke (p = 0.002). The prevalence of hypertension (p &lt; 0.001), diabetes (p = 0.004), dyslipidaemia (p &lt; 0.001) and chronic kidney disease (p = 0.003) was higher amongst transplant recipients with DA. Patients with DA were more likely to suffer an ischaemic stroke (p &lt; 0.001) or haemorrhagic stroke (p = 0.032), or develop septicaemia (p = 0.050) during hospitalisation for HTx. Our analysis found no significant differences between the groups with respect to in-hospital mortality. The female sex and mechanical circulatory support were associated with an inferior prognosis. Pretransplant non-ischaemic cardiomyopathy was related to a favourable outcome. Conclusions: DA affect up to a third of the population undergoing HTx, with a greater prevalence in patients with comorbidities. DA are associated with a higher incidence of stroke and septicaemia after HTx.<\/jats:p>","DOI":"10.3390\/jpm13050844","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T02:04:05Z","timestamp":1684289045000},"page":"844","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-604X","authenticated-orcid":false,"given":"Emyal","family":"Alyaydin","sequence":"first","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Albert Schweitzer Campus 1, A1, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen Reinhard","family":"Sindermann","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Albert Schweitzer Campus 1, A1, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3640-2995","authenticated-orcid":false,"given":"Jeanette","family":"K\u00f6ppe","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-683X","authenticated-orcid":false,"given":"Joachim","family":"Gerss","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0263-3154","authenticated-orcid":false,"given":"Patrik","family":"Dr\u00f6ge","sequence":"additional","affiliation":[{"name":"AOK Research Institute (WIdO), 10178 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ruhnke","sequence":"additional","affiliation":[{"name":"AOK Research Institute (WIdO), 10178 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"G\u00fcnster","sequence":"additional","affiliation":[{"name":"AOK Research Institute (WIdO), 10178 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[{"name":"Department of Cardiology I\u2014Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Albert Schweitzer Campus 1, A1, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik","family":"Feld","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref_1","unstructured":"(2023, March 21). Depression and Other Common Mental Disorders: Global Health Estimates. World Health Organization. Available online: http:\/\/www.who.int\/mental_health\/management\/depression\/prevalence_global_health_estimates\/en."},{"key":"ref_2","first-page":"A14","article-title":"The vital link between chronic disease and depressive disorders","volume":"2","author":"Chapman","year":"2005","journal-title":"Prev. Chronic Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/HRP.0000000000000162","article-title":"Depression and Anxiety in Heart Failure: A Review","volume":"26","author":"Celano","year":"2018","journal-title":"Harv. Rev. Psychiatry."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2006.06.055","article-title":"Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes","volume":"48","author":"Rutledge","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13019-017-0626-0","article-title":"Pre-transplant depression as a predictor of adherence and morbidities after orthotopic heart transplantation","volume":"12","author":"Delibasic","year":"2017","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.healun.2010.05.034","article-title":"The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients","volume":"29","author":"Costanzo","year":"2010","journal-title":"J. Heart Lung Transplant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e14096","DOI":"10.1111\/ctr.14096","article-title":"Gender differences in heart transplantation: Twenty-five year trends in the nationwide Spanish heart transplant registry","volume":"34","year":"2020","journal-title":"Clin. Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100149","DOI":"10.1016\/j.lanepe.2021.100149","article-title":"Associations between physical multimorbidity patterns and common mental health disorders in middle-aged adults: A prospective analysis using data from the UK Biobank","volume":"8","author":"Ronaldson","year":"2021","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s11606-011-1704-y","article-title":"Depression and medication adherence in the treatment of chronic diseases in the United States: A meta-analysis","volume":"26","author":"Grenard","year":"2011","journal-title":"J. Gen. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/eurheartj\/eht462","article-title":"Depression and cardiovascular disease: A clinical review","volume":"35","author":"Hare","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_11","unstructured":"Health Quality Ontario (2013). Screening and management of depression for adults with chronic diseases: An evidence-based analysis. Ont. Health Technol. Assess Ser., 13, 1\u201345."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2015.10.023","article-title":"The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update","volume":"35","author":"Mehra","year":"2016","journal-title":"J. Heart Lung Transplant."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1017\/S0033291703008596","article-title":"Major depression and cigarette smoking: Results of a 21-year longitudinal study","volume":"33","author":"Fergusson","year":"2003","journal-title":"Psychol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archpsyc.55.2.161","article-title":"Major depression and stages of smoking. A longitudinal investigation","volume":"55","author":"Breslau","year":"1998","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jpsychires.2010.06.006","article-title":"Tobacco smoking as a risk factor for depression. A 26-year population-based follow-up study","volume":"45","author":"Flachs","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1093\/eurheartj\/ehy913","article-title":"Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation","volume":"41","author":"Vaccarino","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_17","first-page":"19","article-title":"AHA science advisory. Depression and coronary heart disease. Recommendations for screening, referral, and treatment. A science advisory from the American Heart Association Prevention Committee to the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care Outcomes Research. Endorsed by the American Psychiatric Association","volume":"24","author":"Lichtman","year":"2009","journal-title":"Prog. Cardiovasc. Nurs."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jad.2012.03.025","article-title":"Anxiety and depression after cancer diagnosis: Prevalence rates by cancer type, gender, and age","volume":"141","author":"Linden","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0022-3999(98)00010-5","article-title":"Psychological distress in patients awaiting heart transplantation","volume":"45","author":"Zipfel","year":"1998","journal-title":"J. Psychosom. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/jamaneurol.2016.4529","article-title":"Association of Selective Serotonin Reuptake Inhibitors with the Risk for Spontaneous Intracranial Hemorrhage","volume":"74","author":"Renoux","year":"2017","journal-title":"JAMA Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/archinternmed.2007.32","article-title":"Increased bleeding risk with concurrent use of selective serotonin reuptake inhibitors and coumarins","volume":"168","author":"Schalekamp","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/S0049-3848(19)30362-7","article-title":"Antidepressants: Bleeding or thrombosis?","volume":"181","author":"Nardi","year":"2019","journal-title":"Thromb. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/17425255.2020.1700952","article-title":"Clinically relevant drug interactions between newer antidepressants and oral anticoagulants","volume":"16","author":"Spina","year":"2020","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1503\/cmaj.100912","article-title":"Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction","volume":"183","author":"Labos","year":"2011","journal-title":"Can. Med. Assoc. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0165-1781(98)00139-5","article-title":"Stress, depression and immunity: The role of defense and coping styles","volume":"85","author":"Olff","year":"1999","journal-title":"Psychiatry Res."},{"key":"ref_26","first-page":"549","article-title":"Long-term outcome following heart transplantation: Current perspective","volume":"7","author":"Wilhelm","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1053-2498(00)00327-2","article-title":"Cardiac transplantation for cardiomyopathy and ischemic heart disease: Differences in outcome up to 10 years","volume":"20","author":"Aziz","year":"2001","journal-title":"J. Heart Lung Transplant."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.healun.2019.08.004","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report-2019; focus theme: Donor and recipient size match","volume":"38","author":"Khush","year":"2019","journal-title":"J. Heart Lung Transplant."},{"key":"ref_29","first-page":"419","article-title":"The impact of gender on heart transplantation outcomes: A single center experience","volume":"3","author":"Marra","year":"2002","journal-title":"Ital. Heart J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.healun.2020.11.004","article-title":"Improved survival after heart transplantation in patients bridged with extracorporeal membrane oxygenation in the new allocation system","volume":"40","author":"Gonzalez","year":"2021","journal-title":"J. Heart Lung Transplant."},{"key":"ref_31","first-page":"200","article-title":"Mechanical circulatory support after heart transplantation","volume":"41","author":"Mihaljevic","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/5\/844\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:36:32Z","timestamp":1760124992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/5\/844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jpm13050844"],"URL":"https:\/\/doi.org\/10.3390\/jpm13050844","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]}}}