{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:55:51Z","timestamp":1783940151957,"version":"3.55.0"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Objective: Given the improvement in the surgical treatment of endometrial cancer with the inclusion of sentinel lymph node biopsy (SLNB), our aim was to evaluate the impact of this minimally invasive and tailored nodal assessment on patients\u2019 quality of life (QoL). Methods: This was a cross-sectional study conducted in a single-centre, tertiary-level hospital. Patients diagnosed with preoperative early-stage endometrial cancer, who underwent primary surgical treatment between August 2015 and November 2021, were included. The enrolled patients were divided into two cohorts according to the nodal staging performed: the first group underwent only SLNB (SLNB group); the second group underwent pelvic and\/or para-aortic lymphadenectomy (LND group). We evaluated the overall QoL using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life core 30-item questionnaire (EORTC QLQ-C30) and a sexual health questionnaire (EORTC SHQ-C20). The scores were compared between the groups. Results: Ninety patients were enrolled in the study: 61 (67.8%) in the SLNB group and 29 (32.2%) in the LND group. In the LND group, 24 (82.7%) patients underwent pelvic and para-aortic LND, while 5 (17.3%) patients underwent pelvic LND. The assessment of the functional scales showed better results for the SLNB group than for the LND group, with a significantly lower impact on physical status (8.2% vs. 25%, respectively; p = 0.031). In terms of the symptom scales, the SLNB group reported a significantly lower negative impact on sleep quality (4.9% vs. 27.6%, respectively; p &lt; 0.01), pain (1.6% vs. 13.8%, respectively; p = 0.019), and dyspnoea (0% vs. 10.3%, respectively; p = 0.011) than the LND group. The SLNB group had better results for all analysed items regarding sexual QoL. Conclusions: The implementation of a surgical technique with SLNB improved patients\u2019 overall QoL by increasing their well-being in the functional and symptom spheres.<\/jats:p>","DOI":"10.3390\/jpm13050847","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T08:09:44Z","timestamp":1684397384000},"page":"847","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sentinel Lymph Node Impact on the Quality of Life of Patients with Endometrial Cancer"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-3630","authenticated-orcid":false,"given":"Virginia","family":"Garc\u00eda-Pineda","sequence":"first","affiliation":[{"name":"Gynaecologic Oncology Unit, La Paz University Hospital\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Gynaecologic Oncology Unit, La Paz University Hospital\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Garrido-Mallach","sequence":"additional","affiliation":[{"name":"Gynaecologic Oncology Unit, La Paz University Hospital\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1152-4486","authenticated-orcid":false,"given":"Elena","family":"Rodr\u00edguez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, La Paz University Hospital\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Alonso-Esp\u00edas","sequence":"additional","affiliation":[{"name":"Gynaecologic Oncology Unit, La Paz University Hospital\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-5270","authenticated-orcid":false,"given":"Myriam","family":"Gracia","sequence":"additional","affiliation":[{"name":"Gynaecologic Oncology Unit, La Paz University Hospital\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Arnedo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, La Paz University Hospital\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-7767","authenticated-orcid":false,"given":"Ignacio","family":"Zapardiel","sequence":"additional","affiliation":[{"name":"Gynaecologic Oncology Unit, La Paz University Hospital\u2014IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3322\/caac.21731","article-title":"Cancer treatment and survivorship statistics, 2022","volume":"72","author":"Miller","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ijgo.13866","article-title":"Cancer of the corpus uteri: 2021 update","volume":"155","author":"Koskas","year":"2021","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1200\/JCO.2009.22.3248","article-title":"Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study LAP2","volume":"27","author":"Walker","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1093\/jnci\/djn397","article-title":"Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: Randomized clinical trial","volume":"100","author":"Panici","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"ASTEC Study Group, Kitchener, H., Swart, A.M., Maneschi, F., Lissoni, A.A., Signorelli, M., Scambia, G., and Mangioni, C. (2009). Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): A randomised study. Lancet, 373, 125\u2013136. Erratum in Lancet2009, 373, 1764.","DOI":"10.1016\/S0140-6736(08)61766-3"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S1470-2045(17)30068-2","article-title":"A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): A multicentre, prospective, cohort study","volume":"18","author":"Rossi","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/S1470-2045(18)30448-0","article-title":"Near- infrared fluorescence for detection of sentinel lymph nodes in women with cervical and uterine cancers (FILM): A randomised, phase 3, multicentre, non-inferiority trial","volume":"19","author":"Frumovitz","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejca.2019.04.025","article-title":"Pelvic Sentinel lymph node detection in High-Risk Endometrial Cancer (SHREC-trial)\u2014The final step towards a paradigm shift in surgical staging","volume":"116","author":"Persson","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jamasurg.2020.5060","article-title":"Assessment of Sentinel Lymph Node Biopsy vs Lymphadenectomy for Intermediate- and High-Grade Endometrial Cancer Staging","volume":"156","author":"Cusimano","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_11","unstructured":"(2023, April 01). NCCN Clinical Practice Guideline in Oncology. Uterine neoplasm. Version 1.2023\u201422 December 2022. Available online: https:\/\/www2.tri-kobe.org\/nccn\/guideline\/gynecological\/english\/uterine.pdf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1038\/s41598-019-38759-5","article-title":"Impact of gynecologic cancer on pelvic floor disorder symptoms and quality of life: An observational study","volume":"9","author":"Neron","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1097\/IGC.0b013e31827277fa","article-title":"Sexual Function of Patients With Endometrial Cancer Enrolled in the Gynecologic Oncology Group LAP2 Study","volume":"22","author":"Carter","year":"2012","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.23736\/S0026-4806.20.07117-7","article-title":"Sentinel lymph-node for endometrial cancer treatment: Review of literature","volume":"112","author":"Zorzato","year":"2021","journal-title":"Minerva Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ygyno.2021.01.030","article-title":"Lymphadenectomy is associated with an increased risk of postoperative venous thromboembolism in early stage endometrial cancer","volume":"161","author":"Latif","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ygyno.2020.10.026","article-title":"Standardization of lower extremity quantitative lymphedema measurements and associated patient-reported outcomes in gynecologic cancers","volume":"160","author":"Russo","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejca.2021.06.003","article-title":"Psychometric validation of the European Organisation for Research and Treatment of Cancer\u2013Quality of Life Questionnaire Sexual Health (EORTC QLQ-SH22)","volume":"154","author":"Greimel","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ygyno.2017.12.017","article-title":"Faculty Opinions recommendation of Sentinel lymph node biopsy in endometrial cancer-Feasibility, safety and lymphatic complications","volume":"148","author":"Geppert","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/ijgc-2020-001924","article-title":"Reduced lymphedema after sentinel lymph node biopsy versus lymphadenectomy for endometrial cancer","volume":"31","author":"Glaser","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ygyno.2019.11.003","article-title":"Patient-reported outcomes after surgery for endometrial carcinoma: Prevalence of lower-extremity lymphedema after sentinel lymph node mapping versus lymphadenectomy","volume":"156","author":"Leitao","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ygyno.2020.10.023","article-title":"GOG 244-The Lymphedema and Gynecologic cancer (LeG) study: The impact of lower-extremity lymphedema on quality of life, psychological adjustment, physical disability, and function","volume":"160","author":"Carter","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1177\/10547738211052387","article-title":"The Effect of Treatment on Quality of Life, Symptoms, and Social Life in Gynecologic Cancer Patients","volume":"31","year":"2022","journal-title":"Clin. Nurs. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ygyno.2017.11.007","article-title":"Life after endometrial cancer: A systematic review of patient-reported outcomes","volume":"148","author":"Shisler","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/01443615.2020.1787969","article-title":"Life quality of endometrioid endometrial cancer survivors: A cross-sectional study","volume":"41","author":"Can","year":"2021","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ygyno.2015.01.117","article-title":"Sexual and marital dysfunction in women with gynecologic cancer: Results of a multi-institutional, cross-sectional trial","volume":"137","author":"Guntupalli","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1002\/pon.4832","article-title":"Quality of life after pelvic exenteration for gynecologic cancer: Findings from a qualitative study","volume":"27","author":"Nelson","year":"2018","journal-title":"Psycho-Oncology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1136\/ijgc-2021-002890","article-title":"Risk factors for lymphedema and method of assessment in endometrial cancer: A prospective longitudinal multicenter study","volume":"31","author":"Wedin","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1136\/ijgc-2022-003378","article-title":"Sentinel lymph node mapping versus sentinel lymph node mapping with systematic lymphadenectomy in endometrial cancer: An open-label, non-inferiority, randomized trial (ALICE trial)","volume":"32","author":"Baiocchi","year":"2022","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.3802\/jgo.2021.32.e60","article-title":"Sentinel lymph Node mapping versus systematic pelvic lymphadenectomy on the prognosis for patients with intermediate-high-risk Endometrial Cancer confined to the uterus before surgery: Trial protocol for a non-inferiority randomized controlled trial (SNEC trial)","volume":"32","author":"Guan","year":"2021","journal-title":"J. Gynecol. Oncol."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/5\/847\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:37:03Z","timestamp":1760125023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/5\/847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jpm13050847"],"URL":"https:\/\/doi.org\/10.3390\/jpm13050847","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]}}}