{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:04:48Z","timestamp":1784603088006,"version":"3.55.0"},"reference-count":43,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by patterns in which unwanted thoughts and fears are evoked as obsessions and furthermore, compulsive behaviors are provoked repeatedly, with a prevalence rate of 2% of the population. These obsessive-compulsive symptoms disrupt daily life and cause great distress to the individual. At present, OCD is treated with antidepressants, mainly selective serotonin reuptake inhibitors, and psychotherapy, including the exposure and response prevention method. However, these approaches may only show a certain level of efficacy, and approximately 50% of patients with OCD show treatment resistance. This situation has led to the research and development of neuromodulation therapies, including transcranial magnetic stimulation treatment, for OCD worldwide in recent years. In this case series, we retrospectively analyzed the TMS registry data of continuous theta burst stimulation (cTBS) therapy targeting the bilateral supplementary motor cortex for six patients with OCD whose obsessive-compulsive symptoms had not improved with pharmacotherapy. The results suggest that treatment with cTBS for the bilateral supplementary motor area may reduce obsessive-compulsive symptoms in patients with OCD, despite the limitations of an open-label preliminary case series. The present findings warrant further validation with a randomized, sham-controlled trial with a larger sample size in the future.<\/jats:p>","DOI":"10.3390\/jpm13050875","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T03:20:06Z","timestamp":1684812006000},"page":"875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Case Series of Continuous Theta Burst Stimulation Treatment for the Supplementary Motor Area Twice a Day in Patients with Obsessive-Compulsive Disorder: A Real World TMS Registry Study in Japan"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2155-0357","authenticated-orcid":false,"given":"Yoshihiro","family":"Noda","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan"},{"name":"Shinjuku-Yoyogi Mental Lab Clinic, Tokyo 151-0051, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoshiro","family":"Fujii","sequence":"additional","affiliation":[{"name":"Shinjuku-Yoyogi Mental Lab Clinic, Tokyo 151-0051, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Tokura","sequence":"additional","affiliation":[{"name":"Shinjuku-Yoyogi Mental Lab Clinic, Tokyo 151-0051, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan"},{"name":"Shinjuku-Yoyogi Mental Lab Clinic, Tokyo 151-0051, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Kitahata","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psc.2022.10.006","article-title":"Obsessive-Compulsive Disorder: Diagnosis, Clinical Features, Nosology, and Epidemiology","volume":"46","author":"Cervin","year":"2023","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"152352","DOI":"10.1016\/j.comppsych.2022.152352","article-title":"Treatment-resistant OCD: Pharmacotherapies in adults","volume":"120","author":"Grassi","year":"2023","journal-title":"Compr. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/7854_2020_206","article-title":"Invasive and Non-invasive Neurostimulation for OCD","volume":"49","author":"Bergfeld","year":"2021","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.psc.2014.06.003","article-title":"Neuromodulation in obsessive-compulsive disorder","volume":"37","author":"Bais","year":"2014","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/s41386-020-00928-w","article-title":"Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: A randomized, sham-controlled trial","volume":"46","author":"Silva","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1176\/appi.ajp.2019.18101180","article-title":"Efficacy and Safety of Deep Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder: A Prospective Multicenter Randomized Double-Blind Placebo-Controlled Trial","volume":"176","author":"Carmi","year":"2019","journal-title":"Am. J. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.nicl.2018.05.029","article-title":"Transcranial magnetic stimulation in obsessive-compulsive disorder: A focus on network mechanisms and state dependence","volume":"19","author":"Cocchi","year":"2018","journal-title":"Neuroimage Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuron.2004.12.033","article-title":"Theta burst stimulation of the human motor cortex","volume":"45","author":"Huang","year":"2005","journal-title":"Neuron"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2005.01.008","article-title":"Toward establishing a therapeutic window for rTMS by theta burst stimulation","volume":"45","author":"Paulus","year":"2005","journal-title":"Neuron"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s10548-009-0084-7","article-title":"Mechanisms and applications of theta-burst rTMS on the human motor cortex","volume":"22","author":"Nowak","year":"2010","journal-title":"Brain Topogr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.clinph.2010.08.016","article-title":"The theoretical model of theta burst form of repetitive transcranial magnetic stimulation","volume":"122","author":"Huang","year":"2011","journal-title":"Clin. Neurophysiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/cercor\/bhm087","article-title":"Effect of physiological activity on an NMDA-dependent form of cortical plasticity in human","volume":"18","author":"Huang","year":"2008","journal-title":"Cereb. Cortex"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neubiorev.2016.01.008","article-title":"Use of theta-burst stimulation in changing excitability of motor cortex: A systematic review and meta-analysis","volume":"63","author":"Chung","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"104574","DOI":"10.1016\/j.neubiorev.2022.104574","article-title":"Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis","volume":"135","author":"Liu","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0896-6273(00)00113-6","article-title":"Toward a neurobiology of obsessive-compulsive disorder","volume":"28","author":"Graybiel","year":"2000","journal-title":"Neuron"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/jnnp-2020-324478","article-title":"Defining functional brain networks underlying obsessive-compulsive disorder (OCD) using treatment-induced neuroimaging changes: A systematic review of the literature","volume":"92","author":"Bijanki","year":"2021","journal-title":"J. Neurol Neurosurg. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1590\/1516-4446-2019-0344","article-title":"Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: A systematic review","volume":"41","author":"Marques","year":"2019","journal-title":"Braz. J. Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.31083\/j.jin2106172","article-title":"Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder and Tic Disorder: A Quick Review","volume":"21","author":"Yu","year":"2022","journal-title":"J. Integr. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41398-021-01453-0","article-title":"Efficacy and tolerability of repetitive transcranial magnetic stimulation for the treatment of obsessive-compulsive disorder in adults: A systematic review and network meta-analysis","volume":"11","author":"Liang","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jad.2022.01.048","article-title":"Repetitive transcranial magnetic stimulation for obsessive-compulsive disorder: A systematic review and pairwise\/network meta-analysis","volume":"302","author":"Fitzsimmons","year":"2022","journal-title":"J. Affect. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jpsychires.2013.03.022","article-title":"Repetitive transcranial magnetic stimulation (rTMS) for obsessive-compulsive disorder (OCD): An exploratory meta-analysis of randomized and sham-controlled trials","volume":"47","author":"Berlim","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s11126-018-9566-7","article-title":"A Meta-Analysis of the Effectiveness of Different Cortical Targets Used in Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Obsessive-Compulsive Disorder (OCD)","volume":"89","author":"Rehn","year":"2018","journal-title":"Psychiatr. Q."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jpsychires.2020.10.030","article-title":"Functional connectivity changes and symptoms improvement after personalized, double-daily dosing, repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: A pilot study","volume":"136","author":"Mantovani","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1192\/j.eurpsy.2022.2323","article-title":"Continuous theta burst stimulation over the bilateral supplementary motor area in obsessive-compulsive disorder treatment: A clinical randomized single-blind sham-controlled trial","volume":"65","author":"Guo","year":"2022","journal-title":"Eur. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ikawa, H., Osawa, R., Sato, A., Mizuno, H., and Noda, Y. (2022). A Case Series of Deep Transcranial Magnetic Stimulation Treatment for Patients with Obsessive-Compulsive Disorder in the Tokyo Metropolitan Area. J. Clin. Med., 11.","DOI":"10.3390\/jcm11206133"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Noda, Y., Kizaki, J., Takahashi, S., and Mimura, M. (2022). TMS Database Registry Consortium Research Project in Japan (TReC-J) for Future Personalized Psychiatry. J. Pers. Med., 12.","DOI":"10.3390\/jpm12050844"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_28","first-page":"5","article-title":"Practice guideline for the treatment of patients with obsessive-compulsive disorder","volume":"164","author":"Koran","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1113\/jphysiol.2005.087288","article-title":"Theta-burst repetitive transcranial magnetic stimulation suppresses specific excitatory circuits in the human motor cortex","volume":"565","author":"Pilato","year":"2005","journal-title":"J. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1017\/S1461145705005729","article-title":"Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) and Tourette\u2019s syndrome (TS)","volume":"9","author":"Mantovani","year":"2006","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1017\/S1461145709990435","article-title":"Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder","volume":"13","author":"Mantovani","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jad.2017.03.033","article-title":"An updated meta-analysis: Short-term therapeutic effects of repeated transcranial magnetic stimulation in treating obsessive-compulsive disorder","volume":"215","author":"Zhou","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/npp.2015.292","article-title":"Reductions in Cortico-Striatal Hyperconnectivity Accompany Successful Treatment of Obsessive-Compulsive Disorder with Dorsomedial Prefrontal rTMS","volume":"41","author":"Dunlop","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.brs.2019.10.020","article-title":"Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial","volume":"13","author":"Dunlop","year":"2020","journal-title":"Brain Stimul."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.24869\/psyd.2017.218","article-title":"Bilateral DMPFC-rTMS Leads to Sustained Remission in Geriatric Treatment-Resistant Depression: A Case Report","volume":"29","author":"Sender","year":"2017","journal-title":"Psychiatr. Danub."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40337-021-00411-x","article-title":"A pilot trial of repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex in anorexia nervosa: Resting fMRI correlates of response","volume":"9","author":"Woodside","year":"2021","journal-title":"J. Eat. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Acevedo, N., Bosanac, P., Pikoos, T., Rossell, S., and Castle, D. (2021). Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review. Brain Sci., 11.","DOI":"10.3390\/brainsci11070948"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4103\/0019-5545.91909","article-title":"Augmentation effect of repetitive transcranial magnetic stimulation over the supplementary motor cortex in treatment refractory patients with obsessive compulsive disorder","volume":"53","author":"Kumar","year":"2011","journal-title":"Indian J. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1176\/appi.neuropsych.11100242","article-title":"A randomized, double-blind trial of repetitive transcranial magnetic stimulation in obsessive-compulsive disorder with three-month follow-up","volume":"24","author":"Gomes","year":"2012","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hawken, E.R., Dilkov, D., Kaludiev, E., Simek, S., Zhang, F., and Milev, R. (2016). Transcranial Magnetic Stimulation of the Supplementary Motor Area in the Treatment of Obsessive-Compulsive Disorder: A Multi-Site Study. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030420"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1177\/0269881116628427","article-title":"Better than treated as usual: Transcranial magnetic stimulation augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder, mini-review and pilot open-label trial","volume":"30","author":"Pallanti","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/YCT.0000000000000509","article-title":"Augmentation Effect of Low-Frequency Repetitive Transcranial Magnetic Stimulation Over Presupplementary Motor Area in Obsessive-Compulsive Disorder: A Randomized Controlled Trial","volume":"34","author":"Arumugham","year":"2018","journal-title":"J. ECT"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.brs.2019.07.019","article-title":"Continuous theta burst stimulation over the supplementary motor area in refractory obsessive-compulsive disorder treatment: A randomized sham-controlled trial","volume":"12","author":"Rachid","year":"2019","journal-title":"Brain Stimul."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/5\/875\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:40:09Z","timestamp":1760125209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/5\/875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["jpm13050875"],"URL":"https:\/\/doi.org\/10.3390\/jpm13050875","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]}}}