{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:05:48Z","timestamp":1792789548055,"version":"4.5.0"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese scholarship council","award":["202208080295"],"award-info":[{"award-number":["202208080295"]}]},{"name":"Chinese scholarship council","award":["202108080019"],"award-info":[{"award-number":["202108080019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Aortic dissection (AD) is a life-threatening cardiovascular disease. Pathophysiologically, it has been shown that aortic wall inflammation promotes the occurrence and development of aortic dissection. Thus, the aim of the current research was to determine the inflammation-related biomarkers in AD. Methods: In this study, we conducted differentially expressed genes (DEGs) analysis using the GSE153434 dataset containing 10 type A aortic dissection (TAAD) and 10 normal samples downloaded from the Gene Expression Omnibus (GEO) database. The intersection of DEGs and inflammation-related genes was identified as differential expressed inflammation-related genes (DEIRGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed for DEIRGs. We then constructed the protein\u2013protein interaction (PPI) network using the Search Tool for the Retrieval of Interacting Genes\/Proteins (STRING) database and identified hub genes using the Cytoscape plugin MCODE. Finally, least absolute shrinkage and selection operator (LASSO) logistic regression was used to construct a diagnostic model. Results: A total of 1728 DEGs were identified between the TAAD and normal samples. Thereafter, 61 DEIRGs are obtained by taking the intersection of DEGs and inflammation-related genes. The GO indicated that DEIRGs were mainly enriched in response to lipopolysaccharide, in response to molecules of bacterial origin, secretory granule membrane, external side of plasma, receptor ligand activity, and signaling receptor activator activity. KEGG analysis indicated that DEIRGs were mainly enriched in cytokine\u2013cytokine receptor interaction, TNF signaling pathway, and proteoglycans in cancer. We identified MYC, SELL, HIF1A, EDN1, SERPINE1, CCL20, IL1R1, NOD2, TLR2, CD69, PLAUR, MMP14, and HBEGF as hub genes using the MCODE plug-in. The ROC indicated these genes had a good diagnostic performance for TAAD. Conclusion: In conclusion, our study identified 13 hub genes in the TAAD. This study will be of significance for the future development of a preventive therapy of TAAD.<\/jats:p>","DOI":"10.3390\/jpm13060990","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T02:26:56Z","timestamp":1686709616000},"page":"990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of Inflammation-Related Genes in Patients with Stanford Type A Aortic Dissection"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-9864","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"},{"name":"European Center of Angioscience ECAS, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"},{"name":"European Center of Angioscience ECAS, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vugar","family":"Yagublu","sequence":"additional","affiliation":[{"name":"Surgical Clinic Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuh","family":"Rahbari","sequence":"additional","affiliation":[{"name":"Surgical Clinic Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1046","authenticated-orcid":false,"given":"Christoph","family":"Rei\u00dffelder","sequence":"additional","affiliation":[{"name":"Surgical Clinic Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-3131","authenticated-orcid":false,"given":"Michael","family":"Keese","sequence":"additional","affiliation":[{"name":"European Center of Angioscience ECAS, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"},{"name":"Department of Vascular Surgery, Theresienkrankenhaus, 68165 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"ref_1","first-page":"w14489","article-title":"Acute aortic dissection: Pathogenesis, risk factors and diagnosis","volume":"147","author":"Gawinecka","year":"2017","journal-title":"Swiss Med. Wkly."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jvs.2021.08.080","article-title":"A systematic review and meta-analysis of the incidence of acute aortic dissections in population-based studies","volume":"75","author":"Gouveia","year":"2022","journal-title":"J. Vasc. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccl.2017.03.004","article-title":"Acute Type A Aortic Dissection","volume":"35","author":"Elsayed","year":"2017","journal-title":"Cardiol. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wortmann, M., Peters, A.S., Erhart, P., Korfer, D., Bockler, D., and Dihlmann, S. (2021). Inflammasomes in the Pathophysiology of Aortic Disease. Cells, 10.","DOI":"10.3390\/cells10092433"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zhou, Z., Liu, Y., Zhu, X., Tang, X., Wang, Y., Wang, J., Xu, C., Wang, D., Du, J., and Zhou, Q. (2020). Exaggerated Autophagy in Stanford Type A Aortic Dissection: A Transcriptome Pilot Analysis of Human Ascending Aortic Tissues. Genes, 11.","DOI":"10.3390\/genes11101187"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.2147\/IJGM.S354349","article-title":"Inflammation-Related Gene Signature for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma","volume":"15","author":"Lu","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chen, H., and Boutros, P.C. (2011). VennDiagram: A package for the generation of highly-customizable Venn and Euler diagrams in R. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-35"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: An R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gene Ontology Consortium (2017). Expansion of the Gene Ontology knowledgebase and resources. Nucleic Acids Res., 45, D331\u2013D338.","DOI":"10.1093\/nar\/gkw1108"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: Protein-protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1093\/bioinformatics\/btq064","article-title":"GOSemSim: An R package for measuring semantic similarity among GO terms and gene products","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hanzelmann, S., Castelo, R., and Guinney, J. (2013). GSVA: Gene set variation analysis for microarray and RNA-seq data. BMC Bioinform., 14.","DOI":"10.1186\/1471-2105-14-7"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Robin, X., Turck, N., Hainard, A., Tiberti, N., Lisacek, F., Sanchez, J.C., and Muller, M. (2011). pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-77"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e9129","DOI":"10.7717\/peerj.9129","article-title":"The biomarkers of key miRNAs and target genes associated with acute myocardial infarction","volume":"8","author":"Wang","year":"2020","journal-title":"PeerJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI0215334","article-title":"Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms","volume":"110","author":"Longo","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_18","first-page":"e37","article-title":"Aortic Aneurysms and Dissections Series","volume":"40","author":"Shen","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.kint.2016.08.006","article-title":"Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps","volume":"91","author":"Jansen","year":"2017","journal-title":"Kidney Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"276850","DOI":"10.1155\/2015\/276850","article-title":"Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases","volume":"2015","author":"Liu","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_21","first-page":"2559258","article-title":"Inflammation-Related Gene Signature: An Individualized Risk Prediction Model for Kidney Renal Clear Cell Carcinoma","volume":"2022","author":"Zhang","year":"2022","journal-title":"J. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00109-019-01751-7","article-title":"MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells","volume":"97","author":"Zhang","year":"2019","journal-title":"J. Mol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"710425","DOI":"10.3389\/fcvm.2021.710425","article-title":"Association of IL1R1 Coding Variant with Plasma-Level Soluble ST2 and Risk of Aortic Dissection","volume":"8","author":"Jiang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1242\/dmm.003863","article-title":"Stromal regulation of vessel stability by MMP14 and TGFbeta","volume":"3","author":"Sounni","year":"2010","journal-title":"Dis. Model Mech."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.118.313818","article-title":"CD69 Plays a Beneficial Role in Ischemic Stroke by Dampening Endothelial Activation","volume":"124","author":"Brait","year":"2019","journal-title":"Circ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/mab.2019.0009","article-title":"Upregulation of Natural Killer Cells Proliferation by Cytokine Stimulation","volume":"38","author":"Kavaldzhieva","year":"2019","journal-title":"Monoclon. Antib. Immunodiagn. Immunother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e152418","DOI":"10.1172\/JCI152418","article-title":"CD69 expression on regulatory T cells protects from immune damage after myocardial infarction","volume":"132","author":"Rodriguez","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1053\/gast.2003.50157","article-title":"TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells","volume":"124","author":"Rosenstiel","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1161\/ATVBAHA.111.241257","article-title":"Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids","volume":"32","author":"Lee","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbrc.2013.05.097","article-title":"Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice","volume":"437","author":"Takemura","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ebiom.2018.04.022","article-title":"Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance","volume":"31","author":"Zhang","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ebiom.2019.09.041","article-title":"Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1alpha-ADAM17 pathway(\u2730)","volume":"49","author":"Lian","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"549412","DOI":"10.1155\/2015\/549412","article-title":"Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies","volume":"2015","author":"Zimna","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1160\/TH08-05-0273","article-title":"Integration of non-SMAD and SMAD signaling in TGF-beta1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells","volume":"100","author":"Samarakoon","year":"2008","journal-title":"Thromb. Haemost."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/ATVBAHA.111.235721","article-title":"CCL20 is increased in hypercholesterolemic subjects and is upregulated by LDL in vascular smooth muscle cells: Role of NF-kappaB","volume":"31","author":"Calvayrac","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/ATVBAHA.118.311874","article-title":"TLR2 Promotes Vascular Smooth Muscle Cell Chondrogenic Differentiation and Consequent Calcification via the Concerted Actions of Osteoprotegerin Suppression and IL-6-Mediated RANKL Induction","volume":"39","author":"Lee","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/iub.2129","article-title":"Leishmania species-dependent functional duality of toll-like receptor 2","volume":"71","author":"Jafarzadeh","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"7479","DOI":"10.1038\/s41598-020-64514-2","article-title":"DNA methylation and gene expression signatures are associated with ataxia-telangiectasia phenotype","volume":"10","author":"Ndeh","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9061752","DOI":"10.1155\/2022\/9061752","article-title":"Characterizing the Antitumor Effect of Coptis chinensis and Mume Fructus against Colorectal Cancer Based on Pharmacological Analysis","volume":"2022","author":"Gao","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/pace.14436","article-title":"Evaluating systemic immune-inflammation index in patients with implantable cardioverter defibrillator for heart failure with reduced ejection fraction","volume":"45","author":"Hayiroglu","year":"2022","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00059-020-04972-6","article-title":"A simple formula to predict echocardiographic diastolic dysfunction-electrocardiographic diastolic index","volume":"46","author":"Hayiroglu","year":"2021","journal-title":"Herz"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2217\/bmm.14.38","article-title":"Biomarkers for diagnosis and prognostic stratification of aortic dissection: Challenges and perspectives","volume":"8","author":"Morello","year":"2014","journal-title":"Biomark Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.avsg.2020.06.026","article-title":"Identification of Serum Biomarker in Acute Aortic Dissection by Global and Targeted Metabolomics","volume":"68","author":"Zeng","year":"2020","journal-title":"Ann. Vasc. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cca.2010.12.039","article-title":"Biomarkers in aortic dissection","volume":"412","author":"Wen","year":"2011","journal-title":"Clin. Chim. Acta"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/6\/990\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:53:58Z","timestamp":1760126038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/6\/990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":44,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["jpm13060990"],"URL":"https:\/\/doi.org\/10.3390\/jpm13060990","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,13]]}}}