{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:20:11Z","timestamp":1789003211894,"version":"build-2803163510"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Endotoxin, a component of the cell membrane of gram-negative bacteria, is a trigger for dysregulated inflammatory response in sepsis. Extracorporeal purification of endotoxin, through adsorption with polymyxin B, has been studied as a therapeutic option for sepsis. Previous studies suggest that it could be effective in patients with high endotoxin levels or patients with septic shock of moderate severity. Here, we perform a retrospective, single-centre cohort study of 93 patients suffering from abdominal septic shock treated with polymyxin-B hemoperfusion (PMX-HP) between 2015 and 2020. We compared deceased and surviving patients one month after the intervention using X2 and Mann-Whitney U tests. We assessed the data before and after PMX-HP with a Wilcoxon single-rank test and a multivariate logistic regression analysis. There was a significant reduction of SOFA score in the survivors. The expected mortality using APACHE-II was 59.62%, whereas in our sample, the rate was 40.9%. We found significant differences between expected mortality and real mortality only for the group of patients with an SOFA score between 8 and 13. In conclusion, in patients with abdominal septic shock, the addition of PMX-HP to the standard therapy resulted in lower mortality than expected in the subgroup of patients with intermediate severity of illness.<\/jats:p>","DOI":"10.3390\/jpm13071023","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T01:35:11Z","timestamp":1687311311000},"page":"1023","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mortality Risk Prediction in Abdominal Septic Shock Treated with Polymyxin-B Hemoperfusion: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Sergio","family":"Garcia-Ramos","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-5226","authenticated-orcid":false,"given":"Estrela","family":"Caama\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrocinio","family":"Rodr\u00edguez Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Benito","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-3135","authenticated-orcid":false,"given":"Mercedes","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-2903","authenticated-orcid":false,"given":"Ignacio","family":"Garutti","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0223-2262","authenticated-orcid":false,"given":"Patricia","family":"Pi\u00f1eiro","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care Medicine, Gregorio Mara\u00f1on National Hospital, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: Results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Mellhammar","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s00134-018-5463-7","article-title":"Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: A post hoc analysis of the EUPHRATES trial","volume":"44","author":"Klein","year":"2018","journal-title":"Intensive Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.eimc.2009.02.001","article-title":"Aminogluc\u00f3sidos y polimixinas","volume":"27","author":"Molina","year":"2009","journal-title":"Enferm. 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