{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:42:40Z","timestamp":1783122160618,"version":"3.54.6"},"reference-count":35,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The high incidence of hepatocellular carcinoma (HCC) recurrence after surgical resection worsens the long-term prognosis. Besides tumor-related factors, operative factors such as perioperative blood transfusion have been reported to be related to HCC recurrence. However, excessive intraoperative blood loss (IBL) always necessitates blood transfusion, where IBL and blood transfusion may influence oncologic outcomes. We enrolled 142 patients with newly diagnosed single HCC who underwent hepatic resection between March 2010 and July 2021. Patients were stratified into two groups by IBL volume: Group A (IBL \u2265 700 mL, n = 47) and Group B (IBL &lt; 700 mL, n = 95). The clinic\u2013pathologic findings, operative outcomes, and cumulative probability of tumor recurrence and overall survival were compared between the two groups. In the study, increased IBL (1351 \u00b1 698 vs. 354 \u00b1 166, p &lt; 0.001) and blood transfusion (63.8% vs. 6.3%, p &lt; 0.001) were common in Group A, with a greater HCC recurrence (p = 0.001) and poor overall survival (p = 0.017) compared to those in Group B. Preoperative albumin (hazard ratio [HR], 0.471; 95% confidence interval [CI], 0.244\u20130.907, p = 0.024), microvascular invasion (HR, 2.616; 95% CI, 1.298\u20135.273; p = 0.007), and IBL \u2265 700 mL (HR, 2.325; 95% CI, 1.202\u20134.497; p = 0.012) were significant risk factors for tumor recurrence after surgical resection for HCC. In conclusion, efforts to minimize IBL during hepatic resection are important for improving long-term prognosis in HCC patients.<\/jats:p>","DOI":"10.3390\/jpm13071115","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:35:21Z","timestamp":1688949321000},"page":"1115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of Intraoperative Blood Loss on Tumor Recurrence after Surgical Resection in Hepatocellular Carcinoma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-9601","authenticated-orcid":false,"given":"Suk-Won","family":"Suh","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, Chung-Ang University, Seoul 156-755, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-9666","authenticated-orcid":false,"given":"Seung Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Chung-Ang University, Seoul 156-755, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-0329","authenticated-orcid":false,"given":"Yoo Shin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Chung-Ang University, Seoul 156-755, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3322\/caac.21208","article-title":"Cancer statistics, 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA Cancer J Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.bpg.2014.08.010","article-title":"Hepatocellular carcinoma: Current state of the art in diagnosis and treatment","volume":"28","author":"Bruix","year":"2014","journal-title":"Best Pract. 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