{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:53:33Z","timestamp":1792173213553,"version":"4.4.0"},"reference-count":88,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>miRNAs, a class of small non-coding RNAs, play a role in post-transcriptional gene expression. Therefore, this study aimed to conduct a systematic review of miRNAs associated with GDM to build a panel of miRNAs. A bibliographic search was carried out in the PubMed\/Medline, Virtual Health Library (VHL), Web of Science, and EMBASE databases, selecting observational studies in English without time restriction. The protocol was registered on the PROSPERO platform (number CRD42021291791). Fifty-five studies were included in this systematic review, and 82 altered miRNAs in GDM were identified. In addition, four miRNAs were most frequently dysregulated in GDM (mir-16-5p, mir-20a-5p, mir-222-3p, and mir-330-3p). The dysregulation of these miRNAs is associated with the mechanisms of cell cycle homeostasis, growth, and proliferation of pancreatic \u03b2 cells, glucose uptake and metabolism, insulin secretion, and resistance. On the other hand, identifying miRNAs associated with GDM and elucidating its main mechanisms can assist in the characterization and definition of potential biomarkers for the diagnosis and treatment of GDM.<\/jats:p>","DOI":"10.3390\/jpm13071126","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:50:41Z","timestamp":1689123041000},"page":"1126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MicroRNAs Associated with the Pathophysiological Mechanisms of Gestational Diabetes Mellitus: A Systematic Review for Building a Panel of miRNAs"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2707-9324","authenticated-orcid":false,"given":"Pedro Henrique Costa Matos","family":"da Silva","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Pathology, Institute of Biological Sciences, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia 74690-090, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla de Faria","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pathology, Institute of Biological Sciences, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia 74690-090, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pathology, Institute of Biological Sciences, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia 74690-090, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Christine Pincela","family":"da Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pathology, Institute of Biological Sciences, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia 74690-090, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo da Silva","family":"Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pathology, Institute of Biological Sciences, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia 74690-090, GO, Brazil"},{"name":"Department of Biochemistry and Molecular Biology, Institute of Biological Sciences, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia 74690-090, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-7334","authenticated-orcid":false,"given":"Angela Adamski da Silva","family":"Reis","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pathology, Institute of Biological Sciences, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia 74690-090, GO, Brazil"},{"name":"Department of Biochemistry and Molecular Biology, Institute of Biological Sciences, Federal University of Goi\u00e1s (UFG), Goi\u00e2nia 74690-090, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/AOG.0000000000002498","article-title":"ACOG practice bulletin No. 190 Summary: Gestational diabetes mellitus","volume":"131","author":"Caughey","year":"2018","journal-title":"Obs. 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