{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:55:13Z","timestamp":1781618113370,"version":"3.54.5"},"reference-count":69,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Nowadays, more studies deal with \u201cOrthoGeriatrics\u201d, for the co-management of elderly patients suffering fractures, from the admission to the discharge and beyond. For the first time at Cagliari University Hospital, we introduced an orthogeriatric service, in which trained geriatricians stay in orthopedic unit alongside trained orthopedics. The primary aim of the study was to analyze the rate of death and rehospitalization in elderly femur-fractured people of 65 or more years of age, identifying possible predictive factors. The secondary aim of the study was to analyze the recovery of daily living autonomies during the months following surgery. To reach the aim, we designed a prospective study, which is currently ongoing. We evaluated femur-fractured patients aged 65 years or more with a comprehensive geriatric assessment before surgery. The most common fractures were lateral hip ones, treated with osteosynthesis. Cognitive\u2013affective, functional, and nutritional status, mood, and comorbidities were less impaired than in the outpatient service of the same hospital devoted to frail elderly. Pain control was excellent. A significantly low delirium incidence was found. More than a third of the sample were recognized as frail (according to the Survey of Health, Ageing and Retirement in Europe\u2014Frailty Instrument (SHARE-FI)), and over a third of the sample were identified as a moderate-high risk of hospitalization and death (according to Multidimensional Prognostic Index (MPI)). Overall mortality rate was 13.87%, and rehospitalization rate was 11.84%. Frail people were more likely to die than non-frail (HR: 5.64), and pre-frail ones (HR: 3.97); similarly, high-risk patients were more likely to die than low-risk (HR: 8.04), and moderate-risk ones (HR: 5.46). Conversely, neither SHARE-FI nor MPI predicted rehospitalization. Creatinine (OR: 2.66, p = 0.003) and folate (OR: 0.75, p = 0.03) levels were independently associated with death and rehospitalization, respectively. Finally, the patients did recover the lost autonomies later, 6 months after surgery. Our study demonstrated that SHARE-FI and MPI are reliable tools to predict mortality in an orthogeriatric setting, and that creatinine and folate levels should also be measured given their independent association with negative outcomes.<\/jats:p>","DOI":"10.3390\/jpm13071138","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:35:04Z","timestamp":1689554104000},"page":"1138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Orthogeriatric Assessment of the Elderly Patient with Fragility Hip Fracture: Preliminary Results of a Prospective Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4512-9161","authenticated-orcid":false,"given":"Francesco","family":"Salis","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, and Public Health, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Puxeddu","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, and Public Health, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Piras","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery, and Pharmacy, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristella","family":"Belfiori","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, and Public Health, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-454X","authenticated-orcid":false,"given":"Giuseppe","family":"Marongiu","sequence":"additional","affiliation":[{"name":"University Hospital \u201cAzienda Ospedaliero-Universitaria\u201d of Cagliari, 09042 Monserrato, Italy"},{"name":"Department of Surgical Sciences, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Capone","sequence":"additional","affiliation":[{"name":"University Hospital \u201cAzienda Ospedaliero-Universitaria\u201d of Cagliari, 09042 Monserrato, Italy"},{"name":"Department of Surgical Sciences, University of Cagliari, 09100 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Mandas","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, and Public Health, University of Cagliari, 09100 Cagliari, Italy"},{"name":"University Hospital \u201cAzienda Ospedaliero-Universitaria\u201d of Cagliari, 09042 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/geronb\/gbx071","article-title":"Population Aging and Health Trajectories at Older Ages","volume":"74","author":"Vogelsang","year":"2019","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/prd.12126","article-title":"The aging population: Demographics and the biology of aging","volume":"72","author":"Kanasi","year":"2016","journal-title":"Periodontol 2000"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Salis, F., Costaggiu, D., and Mandas, A. (2023). Mini-Mental State Examination: Optimal Cut-Off Levels for Mild and Severe Cognitive Impairment. Geriatrics, 8.","DOI":"10.3390\/geriatrics8010012"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cger.2013.07.009","article-title":"Risk factors for the progression of mild cognitive impairment to dementia","volume":"29","author":"Campbell","year":"2013","journal-title":"Clin. Geriatr. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40292-017-0185-4","article-title":"Management of Hypertension in the Elderly and Frail Elderly","volume":"24","author":"Ferri","year":"2017","journal-title":"High Blood Press Cardiovasc. Prev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.2106\/JBJS.15.00793","article-title":"Global Forum: Fractures in the Elderly","volume":"98","author":"McQueen","year":"2016","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Loddo, S., Salis, F., Rundeddu, S., Serchisu, L., Peralta, M.M., and Mandas, A. (2022). Nutritional Status and Potentially Inappropriate Medications in Elderly. J. Clin. Med., 11.","DOI":"10.3390\/jcm11123465"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"104831","DOI":"10.1016\/j.archger.2022.104831","article-title":"Comprehensive geriatric assessment and multidisciplinary team interventions for hospitalized older adults: A scoping review","volume":"104","author":"Choi","year":"2023","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"984046","DOI":"10.3389\/fmed.2022.984046","article-title":"Geriatric Assessment: Application and correlations in a real-life cross-sectional study","volume":"9","author":"Salis","year":"2022","journal-title":"Front. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/rej.2007.0569","article-title":"Development and validation of a multidimensional prognostic index for one-year mortality from comprehensive geriatric assessment in hospitalized older patients","volume":"11","author":"Pilotto","year":"2008","journal-title":"Rejuvenation Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s40520-020-01718-6","article-title":"Multidimensional Prognostic Index (MPI) in elderly patients with acute myocardial infarction","volume":"33","author":"Cammalleri","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Overbeek, F.C.M.S., Goudzwaard, J.A., van Hemmen, J., van Bruchem-Visser, R.L., Papma, J.M., Polinder-Bos, H.A., and Mattace-Raso, F.U.S. (2022). The Multidimensional Prognostic Index Predicts Mortality in Older Outpatients with Cognitive Decline. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092369"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Salis, F., Cossu, E., and Mandas, A. (2023). The multidimensional prognostic index (MPI) predicts long-term mortality in old type 2 diabetes mellitus patients: A 13-year follow-up study. J. Endocrinol. Investig.","DOI":"10.1007\/s40618-023-02135-y"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101498","DOI":"10.1016\/j.arr.2021.101498","article-title":"Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis","volume":"72","author":"Veronese","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: Evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Romero-Ortuno, R., Walsh, C.D., Lawlor, B.A., and Kenny, R.A. (2010). A frailty instrument for primary care: Findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). BMC Geriatr., 10.","DOI":"10.1186\/1471-2318-10-57"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2468-2667(18)30091-4","article-title":"Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: A prospective analysis of 493 737 UK Biobank participants","volume":"3","author":"Hanlon","year":"2018","journal-title":"Lancet Public Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e650","DOI":"10.1016\/S2468-2667(20)30113-4","article-title":"Frailty index and all-cause and cause-specific mortality in Chinese adults: A prospective cohort study","volume":"5","author":"Fan","year":"2020","journal-title":"Lancet Public Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12933-019-0885-2","article-title":"Relationship between frailty and mortality, hospitalization, and cardiovascular diseases in diabetes: A systematic review and meta-analysis","volume":"18","author":"Ida","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1134453","DOI":"10.3389\/fpubh.2023.1134453","article-title":"Frailty and comorbidity burden in Atrial Fibrillation","volume":"11","author":"Salis","year":"2023","journal-title":"Front. Public Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/gerona\/glt092","article-title":"Epidemiology of fracture risk with advancing age","volume":"68","author":"Ensrud","year":"2013","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.injury.2018.04.015","article-title":"Epidemiology and social costs of hip fracture","volume":"49","author":"Veronese","year":"2018","journal-title":"Injury"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1186502","DOI":"10.3389\/fmed.2023.1186502","article-title":"Six-Item Cognitive Impairment Test (6-CIT)\u2019s Accuracy as a Cognitive Screening Tool: Best Cut-Off Levels in Emergency Department Setting","volume":"10","author":"Salis","year":"2023","journal-title":"Front. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.beem.2008.07.002","article-title":"Osteoporosis and osteoporotic fracture occurrence and prevention in the elderly: A geriatric perspective","volume":"22","author":"Boonen","year":"2008","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00002281-199907000-00015","article-title":"Body mass and bone mineral quality","volume":"11","author":"Chumlea","year":"1999","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bone.2009.10.005","article-title":"Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly","volume":"46","author":"Rizzoli","year":"2010","journal-title":"Bone"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"103461","DOI":"10.1016\/j.otsr.2022.103461","article-title":"Augmented osteosynthesis in fragility fracture","volume":"109","author":"Arlettaz","year":"2023","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cger.2014.01.001","article-title":"Epidemiology of fragility fractures","volume":"30","author":"Friedman","year":"2014","journal-title":"Clin. Geriatr. Med."},{"key":"ref_29","first-page":"1","article-title":"Fractures in the elderly: When is hip replacement a necessity?","volume":"6","author":"Antapur","year":"2011","journal-title":"Clin. Interv. Aging"},{"key":"ref_30","first-page":"945","article-title":"Hip fracture: Diagnosis, treatment, and secondary prevention","volume":"89","author":"LeBlanc","year":"2014","journal-title":"Am. Fam. Physician"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jhsa.2020.07.010","article-title":"Upper Extremity Fragility Fractures","volume":"46","author":"Shoji","year":"2021","journal-title":"J. Hand Surg. Am."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"afac063","DOI":"10.1093\/ageing\/afac063","article-title":"Fragility fractures of the pelvis in the older population","volume":"51","author":"Sivapathasuntharam","year":"2022","journal-title":"Age Ageing"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cger.2014.01.011","article-title":"Fragility fractures requiring special consideration: Vertebral fractures","volume":"30","author":"Kammerlander","year":"2014","journal-title":"Clin. Geriatr. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/ageing\/afu011","article-title":"Orthogeriatrics moving forward","volume":"43","author":"Aw","year":"2014","journal-title":"Age Ageing"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s40001-021-00556-0","article-title":"Management of proximal femur fractures in the elderly: Current concepts and treatment options","volume":"26","author":"Fischer","year":"2021","journal-title":"Eur. J. Med. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1532-5415.1975.tb00927.x","article-title":"A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients","volume":"23","author":"Pfeiffer","year":"1975","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_37","first-page":"33","article-title":"Assessment tools to evaluate Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) in older adults: A systematic review","volume":"34","author":"Pashmdarfard","year":"2020","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0899-9007(98)00171-3","article-title":"The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients","volume":"15","author":"Vellas","year":"1999","journal-title":"Nutrition"},{"key":"ref_39","first-page":"238","article-title":"Mattresses for preventing pressure sores in geriatric patients","volume":"25","author":"Bliss","year":"1966","journal-title":"Mon. Bull. Minist. Health Public Health Lab. Serv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1532-5415.1995.tb06377.x","article-title":"Validation of the Cumulative Illness Rating Scale in a geriatric residential population","volume":"43","author":"Parmelee","year":"1995","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","article-title":"Development and validation of a geriatric depression screening scale: A preliminary report","volume":"17","author":"Yesavage","year":"1982","journal-title":"J. Psychiatr. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1515\/sjpain-2018-0012","article-title":"The validity of pain intensity measures: What do the NRS, VAS, VRS, and FPS-R measure?","volume":"18","author":"Thong","year":"2018","journal-title":"Scand. J. Pain"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/ageing\/afu021","article-title":"Validation of the 4AT, a new instrument for rapid delirium screening: A study in 234 hospitalised older people","volume":"43","author":"Bellelli","year":"2014","journal-title":"Age Ageing"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mcna.2021.12.003","article-title":"Delirium","volume":"106","author":"Keenan","year":"2022","journal-title":"Med. Clin. N. Am."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Salis, F., Locci, G., Mura, B., and Mandas, A. (2023). Anemia in Elderly Patients-The Impact of Hemoglobin Cut-Off Levels on Geriatric Domains. Diagnostics, 13.","DOI":"10.3390\/diagnostics13020191"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/anae.15291","article-title":"Guideline for the management of hip fractures 2020: Guideline by the Association of Anaesthetists","volume":"76","author":"Griffiths","year":"2021","journal-title":"Anaesthesia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00223-021-00943-z","article-title":"Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis","volume":"110","author":"Mordant","year":"2022","journal-title":"Calcif. Tissue Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1007\/s00198-020-05510-0","article-title":"Impact of an orthogeriatrician on length of stay of elderly patient with hip fracture","volume":"31","author":"Aletto","year":"2020","journal-title":"Osteoporos. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/postgradmedj-2017-134991","article-title":"Enhanced recovery after surgery for hip and knee arthroplasty: A systematic review and meta-analysis","volume":"93","author":"Zhu","year":"2017","journal-title":"Postgrad Med. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ocl.2017.05.001","article-title":"Perioperative Pain Management in Hip and Knee Arthroplasty","volume":"48","author":"Gaffney","year":"2017","journal-title":"Orthop. Clin. N. Am."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00198-018-4747-7","article-title":"Length of hospital stay after hip fracture surgery and 1-year mortality","volume":"30","author":"Yoo","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1007\/s40520-013-0104-z","article-title":"Osteosynthesis and hip replacement in proximal femur fractures","volume":"25","author":"Zarattini","year":"2013","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Masnoon, N., Shakib, S., Kalisch-Ellett, L., and Caughey, G.E. (2017). What is polypharmacy? A systematic review of definitions. BMC Geriatr., 17.","DOI":"10.1186\/s12877-017-0621-2"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1001\/jamainternmed.2017.4790","article-title":"The Dangers of Polypharmacy in Elderly Patients","volume":"177","author":"Turgeon","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1570161121666230418163016","article-title":"STOPP\/START Anti-aggregation and Anticoagulation Alerts in Atrial Fibrillation","volume":"21","author":"Salis","year":"2023","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s40520-020-01674-1","article-title":"Incidence and associated factors of delirium after orthopedic surgery in elderly patients: A systematic review and meta-analysis","volume":"33","author":"Yang","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1017\/S104161020600425X","article-title":"The incidence of delirium associated with orthopedic surgery: A meta-analytic review","volume":"19","author":"Bruce","year":"2007","journal-title":"Int. Psychogeriatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2151459321998314","DOI":"10.1177\/2151459321998314","article-title":"Incidence, Risk-Factors and Associated Mortality of Complications in Orthogeriatric Co-Managed Inpatients","volume":"12","author":"Wiedl","year":"2021","journal-title":"Geriatr. Orthop. Surg. Rehabil."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104297","DOI":"10.1016\/j.archger.2020.104297","article-title":"Outcome of fragility hip fractures in elderly patients: Does diabetes mellitus and its severity matter?","volume":"93","author":"Vintenberg","year":"2021","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13018-016-0486-7","article-title":"Polypharmacy and adverse outcomes after hip fracture surgery","volume":"11","author":"Rogmark","year":"2016","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_61","first-page":"CD007125","article-title":"Multidisciplinary rehabilitation for older people with hip fractures","volume":"11","author":"Handoll","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/bs.afnr.2017.12.006","article-title":"Recent Developments in Folate Nutrition","volume":"83","author":"Naderi","year":"2018","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.clnesp.2021.12.027","article-title":"Assessment of sarcopenia and malnutrition using estimated GFR ratio (eGFRcys\/eGFR) in hospitalised adult patients","volume":"48","author":"Yoshida","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Dyer, S.M., Crotty, M., Fairhall, N., Magaziner, J., Beaupre, L.A., Cameron, I.D., Sherrington, C., and Fragility Fracture Network (FFN) Rehabilitation Research Special Interest Group (2016). A critical review of the long-term disability outcomes following hip fracture. BMC Geriatr., 16.","DOI":"10.1186\/s12877-016-0332-0"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJMoa2108337","article-title":"Cemented or Uncemented Hemiarthroplasty for Intracapsular Hip Fracture","volume":"386","author":"Fernandez","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Dakhil, S., Thingstad, P., Frihagen, F., Johnsen, L.G., Lydersen, S., Skovlund, E., Wyller, T.B., Sletvold, O., Saltvedt, I., and Watne, L.O. (2021). Orthogeriatrics prevents functional decline in hip fracture patients: Report from two randomized controlled trials. BMC Geriatr., 21.","DOI":"10.1186\/s12877-021-02152-7"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00198-021-06104-0","article-title":"Self-rated health status and activities of daily living in the first 12 months after fragility fractures of the pelvis-a prospective study on 134 patients","volume":"33","author":"Hack","year":"2022","journal-title":"Osteoporos. Int."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Salis, F., and Mandas, A. (2023). Physical Performance and Falling Risk Are Associated with Five-Year Mortality in Older Adults: An Observational Cohort Study. Medicina, 59.","DOI":"10.3390\/medicina59050964"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/978-981-13-3681-2_16","article-title":"Osteoporosis and the Ageing Skeleton","volume":"91","author":"Aspray","year":"2019","journal-title":"Subcell. Biochem."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/7\/1138\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:12:22Z","timestamp":1760127142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/7\/1138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["jpm13071138"],"URL":"https:\/\/doi.org\/10.3390\/jpm13071138","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,14]]}}}