{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:24:12Z","timestamp":1760149452796,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"budget theme of State Assignment","award":["122031700094-5","21-15-00022"],"award-info":[{"award-number":["122031700094-5","21-15-00022"]}]},{"name":"Russian Science Foundation","award":["122031700094-5","21-15-00022"],"award-info":[{"award-number":["122031700094-5","21-15-00022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: There are data supporting the idea that atherogenic dyslipidemia is a risk factor for CKD and reduced GFR. The aim was to evaluate the associations between adipocytokines and early renal dysfunction in young people with dyslipidemia. Materials and methods: A population study was conducted in IIPM\u2014Branch of IC&amp;G SB RAS, in 2013\u20132017. Furthermore, 1033 people were included in the study (469 men (45.4%) and 564 women (54.6%)). The study included blood sampling, anthropometric data, and adipokines by multiplex analysis. Results: Among people with reduced kidney function and DLP, men were 3.1 times more common than without DLP, women smoked 2 times less often, arterial hypertension was 7.8 times more common, and abdominal obesity was 2.7 times more common (and women with DLP were 3 times more likely than those without DLP). An increase in the level of resistin by 1 mcg\/mL was associated with an increased chance of having renal dysfunction by 0.2%. An increase in the level of GIP was associated with an increased chance of having renal dysfunction by 1.1%. Conclusions: In young people with dyslipidemia, regardless of the presence of abdominal obesity, resistin and GIP are associated with the presence of renal dysfunction.<\/jats:p>","DOI":"10.3390\/jpm13081238","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T10:08:59Z","timestamp":1691575739000},"page":"1238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of Adipocytokines and Early Renal Dysfunction in Young People on the Background of Dyslipidemia"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-4664","authenticated-orcid":false,"given":"Evgeniia V.","family":"Garbuzova","sequence":"first","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2014Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7875-1566","authenticated-orcid":false,"given":"Alyona D.","family":"Khudiakova","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2014Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilia V.","family":"Shcherbakova","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2014Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2268-4186","authenticated-orcid":false,"given":"Elena V.","family":"Kashtanova","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2014Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3538-0280","authenticated-orcid":false,"given":"Yana V.","family":"Polonskaya","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2014Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0484-6540","authenticated-orcid":false,"given":"Ekaterina M.","family":"Stakhneva","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2014Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-8362","authenticated-orcid":false,"given":"Yulia I.","family":"Ragino","sequence":"additional","affiliation":[{"name":"Research Institute of Internal and Preventive Medicine\u2013Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM\u2014Branch of IC&G SB RAS), B. Bogatkova Str., 175\/1, 630089 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-981-13-8871-2_1","article-title":"Prevalence and Disease Burden of Chronic Kidney Disease","volume":"1165","author":"Lv","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.20996\/1819-6446-2020-04-09","article-title":"Glomerular Filtration Rate, Its Association with Risk Factors and Cardiovascular Diseases. The Results of the ESSE-RF-2 Study","volume":"16","author":"Shalnova","year":"2020","journal-title":"Ration. Pharmacother. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1681\/ASN.V133745","article-title":"Renal Insufficiency and Subsequent Death Resulting from Cardiovascular Disease in the United States","volume":"13","author":"Muntner","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.7326\/0003-4819-137-7-200210010-00006","article-title":"Association of Renal Insufficiency with Treatment and Outcomes after Myocardial Infarction in Elderly Patients","volume":"137","author":"Shlipak","year":"2002","journal-title":"Ann. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.23876\/j.krcp.18.0128","article-title":"Impact of Chronic Kidney Disease on Mortality: A Nationwide Cohort Study","volume":"38","author":"Kim","year":"2019","journal-title":"Kidney Res. Clin. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3109\/10715762.2013.779373","article-title":"Oxidative Stress in Patients with Cardiovascular Disease and Chronic Renal Failure","volume":"47","author":"Popolo","year":"2013","journal-title":"Free Radic. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.2215\/CJN.03500412","article-title":"Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC","volume":"7","author":"Gupta","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_8","first-page":"255","article-title":"Inflammation and Poor Response to Treatment with Erythropoietin in Chronic Kidney Disease","volume":"37","author":"Sabino","year":"2015","journal-title":"J. Bras. Nefrol."},{"doi-asserted-by":"crossref","unstructured":"Rapa, S.F., Di Iorio, B.R., Campiglia, P., Heidland, A., and Marzocco, S. (2019). Inflammation and Oxidative Stress in Chronic Kidney Disease-Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. Int. J. Mol. Sci., 21.","key":"ref_9","DOI":"10.3390\/ijms21010263"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0140-6736(12)60572-8","article-title":"Risk of Coronary Events in People with Chronic Kidney Disease Compared with Those with Diabetes: A Population-Level Cohort Study","volume":"380","author":"Tonelli","year":"2012","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1681\/ASN.V1482084","article-title":"Cholesterol and the Risk of Renal Dysfunction in Apparently Healthy Men","volume":"14","author":"Schaeffner","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.atherosclerosis.2019.08.014","article-title":"2019 ESC\/EAS Guidelines for the Management of Dyslipidaemias: Lipid Modification to Reduce Cardiovascular Risk","volume":"290","author":"Mach","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref_14","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO. 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"3","author":"Levin","year":"2013","journal-title":"Kidney Int. Suppl."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.2215\/CJN.02180311","article-title":"Metabolic Syndrome and Kidney Disease: A Systematic Review and Meta-Analysis","volume":"6","author":"Thomas","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1053\/j.ajkd.2015.05.011","article-title":"Impact of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio on the Incidence and Progression of CKD: A Longitudinal Study in a Large Japanese Population","volume":"66","author":"Tsuruya","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10157-017-1407-8","article-title":"Impact of Low-Density Lipoprotein Cholesterol on Decline in Estimated Glomerular Filtration Rate in Apparently Healthy Young to Middle-Aged Working Men","volume":"22","author":"Kuma","year":"2018","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1089\/ars.2008.2034","article-title":"Redox Control of Renal Function and Hypertension","volume":"10","author":"Nistala","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/dom.14496","article-title":"The Evolving Story of Incretins (GIP and GLP-1) in Metabolic and Cardiovascular Disease: A Pathophysiological Update","volume":"23","author":"Nauck","year":"2021","journal-title":"Diabetes Obes. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1111\/dom.14174","article-title":"The Dual Glucose-Dependent Insulinotropic Peptide and Glucagon-like Peptide-1 Receptor Agonist, Tirzepatide, Improves Lipoprotein Biomarkers Associated with Insulin Resistance and Cardiovascular Risk in Patients with Type 2 Diabetes","volume":"22","author":"Wilson","year":"2020","journal-title":"Diabetes Obes. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1210\/jc.2013-3809","article-title":"Elimination and Degradation of Glucagon-like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide in Patients with End-Stage Renal Disease","volume":"99","author":"Idorn","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"654","DOI":"10.2337\/diabetes.53.3.654","article-title":"Secretion, Degradation, and Elimination of Glucagon-like Peptide 1 and Gastric Inhibitory Polypeptide in Patients with Chronic Renal Insufficiency and Healthy Control Subjects","volume":"53","author":"Meier","year":"2004","journal-title":"Diabetes"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1210\/endo.133.6.8243312","article-title":"Gastric Inhibitory Polypeptide Receptor, a Member of the Secretin-Vasoactive Intestinal Peptide Receptor Family, Is Widely Distributed in Peripheral Organs and the Brain","volume":"133","author":"Usdin","year":"1993","journal-title":"Endocrinology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41574-022-00783-3","article-title":"Beyond the Pancreas: Contrasting Cardiometabolic Actions of GIP and GLP1","volume":"19","author":"Hammoud","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"E840","DOI":"10.1161\/CIR.0000000000000664","article-title":"Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement from the American Heart Association","volume":"139","author":"Rangaswami","year":"2019","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/01.CIR.0000084503.91330.49","article-title":"Resistin Promotes Endothelial Cell Activation: Further Evidence of Adipokine-Endothelial Interaction","volume":"108","author":"Verma","year":"2003","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1530\/eje.0.1490331","article-title":"Plasma Resistin, Adiponectin and Leptin Levels in Lean and Obese Subjects: Correlations with Insulin Resistance","volume":"149","author":"Silha","year":"2003","journal-title":"Eur. J. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1530\/eje.1.02338","article-title":"Plasma Resistin Levels Correlate with Determinants of the Metabolic Syndrome","volume":"156","author":"Norata","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jacc.2005.04.022","article-title":"Associations between Serum Resistin Levels and Insulin Resistance, Inflammation, and Coronary Artery Disease","volume":"46","author":"Ohmori","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0140-6736(02)07281-1","article-title":"Resistin, Central Obesity, and Type 2 Diabetes","volume":"359","author":"McTernan","year":"2002","journal-title":"Lancet"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1016\/j.transproceed.2006.10.140","article-title":"Resistin, a New Adipokine, Is Related to Inflammation and Renal Function in Kidney Allograft Recipients","volume":"38","author":"Malyszko","year":"2006","journal-title":"Transplant. Proc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijcard.2007.02.028","article-title":"Association between Serum Resistin and Carotid Intima Media Thickness in Hypertension Patients","volume":"125","author":"Shin","year":"2008","journal-title":"Int. J. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/sj.ki.5000089","article-title":"Elevated Resistin Levels in Chronic Kidney Disease Are Associated with Decreased Glomerular Filtration Rate and Inflammation, but Not with Insulin Resistance","volume":"69","author":"Axelsson","year":"2006","journal-title":"Kidney Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2796.2004.01306.x","article-title":"The Current Biology of Resistin","volume":"255","author":"Steppan","year":"2004","journal-title":"J. Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/HYPERTENSIONAHA.107.095257","article-title":"Association of Plasma Resistin with Glomerular Filtration Rate and Albuminuria in Hypertensive Adults","volume":"50","author":"Ellington","year":"2007","journal-title":"Hypertension"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1172\/JCI107023","article-title":"The Renal Handling of Low Molecular Weight Proteins. II. Disorders of Serum Protein Catabolism in Patients with Tubular Proteinuria, the Nephrotic Syndrome, or Uremia","volume":"51","author":"Waldmann","year":"1972","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.amjcard.2005.05.052","article-title":"Relation of Microalbuminuria to Adiponectin and Augmented C-Reactive Protein Levels in Men with Essential Hypertension","volume":"96","author":"Tsioufis","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.amjhyper.2005.07.026","article-title":"Diverse Associations of Microalbuminuria with C-Reactive Protein, Interleukin-18 and Soluble CD 40 Ligand in Male Essential Hypertensive Subjects","volume":"19","author":"Tsioufis","year":"2006","journal-title":"Am. J. Hypertens."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/jhh.2009.12","article-title":"Independent Association of Circulating Resistin with Glomerular Filtration Rate in the Early Stages of Essential Hypertension","volume":"23","author":"Dimitriadis","year":"2009","journal-title":"J. Hum. Hypertens."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/8\/1238\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:28:28Z","timestamp":1760128108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/8\/1238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["jpm13081238"],"URL":"https:\/\/doi.org\/10.3390\/jpm13081238","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2023,8,9]]}}}