{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:27:12Z","timestamp":1760149632192,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Health Technology R&amp;D Project through the Korea Health Industry Development Institute (KHIDI)","award":["HI21C1624","1711139109 KMDF_PR_20210527_0005"],"award-info":[{"award-number":["HI21C1624","1711139109 KMDF_PR_20210527_0005"]}]},{"name":"Ministry of Health and Welfare, Republic of Korea","award":["HI21C1624","1711139109 KMDF_PR_20210527_0005"],"award-info":[{"award-number":["HI21C1624","1711139109 KMDF_PR_20210527_0005"]}]},{"name":"Korea Medical Device Development Fund grant","award":["HI21C1624","1711139109 KMDF_PR_20210527_0005"],"award-info":[{"award-number":["HI21C1624","1711139109 KMDF_PR_20210527_0005"]}]},{"name":"Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health and Welfare, and the Ministry of Food and Drug Safety of the Korean government","award":["HI21C1624","1711139109 KMDF_PR_20210527_0005"],"award-info":[{"award-number":["HI21C1624","1711139109 KMDF_PR_20210527_0005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Uterine arteriovenous malformation (AVM) is associated with a risk of massive uterine bleeding. Although uterine artery embolization remains the first-line treatment for AVM, there has been a recent exploration of pharmacological options. Danazol is known to reduce blood flow to the uterus; however, our understanding of its therapeutic efficacy for AVM remains limited. Herein, we present the results of danazol use in patients with uterine AVM. We retrospectively reviewed the medical records of patients who received danazol for the treatment of AVM between January 2013 and November 2022. The cohort comprised 10 patients who developed AVM after dilatation and curettage (D&amp;C), abortion, or cesarean section. Danazol was administered twice daily at a total dose of 400 mg\/day, and was employed for AVM treatment in hemodynamically stable patients who provided consent and were devoid of massive bleeding. Outpatient follow-ups (ultrasound measurements of AVM size and symptom assessment) were performed every 2 weeks. AVM was successfully treated with danazol in most patients with no adverse event. Eight postabortal patients had complete resolution of AVM after an average of 45 days (range 14\u201370 days). Of two patients who developed AVM after a cesarean section, one experienced AVM reduction, and the other developed massive bleeding, requiring emergency uterine artery embolization. In light of these outcomes, danazol can be potentially prioritized over uterine artery embolization in the treatment of AVM after abortion in hemodynamically stable patients.<\/jats:p>","DOI":"10.3390\/jpm13091289","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:25:24Z","timestamp":1692775524000},"page":"1289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Danazol as a Treatment for Uterine Arteriovenous Malformation: A Case Report"],"prefix":"10.3390","volume":"13","author":[{"given":"Hyunjin","family":"Tak","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul 07441, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong-No","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Chungnam National University Hospital, Daejeon 35015, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Won","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul 07441, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keun-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul 07441, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-0832","authenticated-orcid":false,"given":"Ga-Hyun","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul 07441, Republic of Korea"},{"name":"Institute of New Frontier Research Team, College of Medicine, Hallym University, Chuncheon 24252, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/00006254-199712000-00004","article-title":"Arteriovenous malformations of the uterus: An uncommon cause of vaginal bleeding","volume":"52","author":"Hoffman","year":"1997","journal-title":"Obstet. 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