{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:05:23Z","timestamp":1780085123876,"version":"3.54.0"},"reference-count":49,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Profesor N\u00f3voa Santos"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The objective of this manuscript was to review the indications, efficacy, and safety of a 585 nm pulsed dye laser (PDL) in non-malignant laryngeal lesions. Following the PRISMA statement recommendations, three independent authors searched for articles published in PubMed\/MEDLINE, the Cochrane Library, Google Scholar, Scielo, and Web of Science. A bias analysis was performed following NICE guidance tools. From the 506 identified publications, 19 observational studies met the inclusion criteria. The PDL improves vocal quality objectively and subjectively in vascular lesions (p &lt; 0.005) and improves vocal quality in patients with dysplasia\/leukoplasia without changing the natural history of the disease compared to other treatments. Reinke\u2019s edema and granulomas require an average of 1.5 PDL sessions for resolution. Treatment of recurrent respiratory papillomatosis requires multiple sessions, with complete remission achieved in 50\u201370% of patients. Regardless of the lesion, the tolerance of the procedure under local anesthesia is exceptional (84\u201397%), and the results in terms of regression and vocal quality are promising. The complication rate is minimal, and the procedure does not interfere with other treatment alternatives. There is no consensus on laser settings. The lack of consistent use in evaluating vocal outcomes, whether objective or subjective, prevents the comparability between studies. The 585 nm pulsed dye laser appears to be an effective and safe therapeutic option in patients with non-malignant laryngeal pathology. Future controlled studies are needed to compare the 585 nm pulsed dye laser with other lasers or cold instrument procedures.<\/jats:p>","DOI":"10.3390\/jpm13091374","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:57:56Z","timestamp":1694685476000},"page":"1374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Indications, Efficacy, Safety, and Clinical Outcomes of 585 nm Pulsed Dye Laser in Non-Malignant Laryngeal Lesions: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Henar","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Otorhinolaryngology\u2014Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-6597","authenticated-orcid":false,"given":"Miguel","family":"Mayo-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology\u2014Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), 15006 A Coru\u00f1a, Spain"},{"name":"Young-Otolaryngologists of the International Federation of Oto-Rhino-Laryngological Societies (YO-IFOS), Research Study Group, 75000 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-6871","authenticated-orcid":false,"given":"Alberto","family":"Maria-Saibene","sequence":"additional","affiliation":[{"name":"Young-Otolaryngologists of the International Federation of Oto-Rhino-Laryngological Societies (YO-IFOS), Research Study Group, 75000 Paris, France"},{"name":"Otolaryngology Unit, Santi Paolo e Carlo Hospital, Department of Health Sciences, Universit\u00e0 degli Studi di Milano, 20142 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Allevi","sequence":"additional","affiliation":[{"name":"Young-Otolaryngologists of the International Federation of Oto-Rhino-Laryngological Societies (YO-IFOS), Research Study Group, 75000 Paris, France"},{"name":"Maxillofacial Surgery Unit, Santi Paolo e Carlo Hospital, Department of Health Sciences, Universit\u00e0 degli Studi di Milano, 20142 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Chiesa-Estomba","sequence":"additional","affiliation":[{"name":"Young-Otolaryngologists of the International Federation of Oto-Rhino-Laryngological Societies (YO-IFOS), Research Study Group, 75000 Paris, France"},{"name":"Otorhinolaryngology\u2014Head and Neck Surgery Department, Hospital Universitario Donostia\u2014Biodonostia Research Institute, 20014 Donostia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-145X","authenticated-orcid":false,"given":"Luigi A.","family":"Vaira","sequence":"additional","affiliation":[{"name":"Young-Otolaryngologists of the International Federation of Oto-Rhino-Laryngological Societies (YO-IFOS), Research Study Group, 75000 Paris, France"},{"name":"Maxillofacial Surgery Operative Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0845-0845","authenticated-orcid":false,"given":"Jerome R.","family":"Lechien","sequence":"additional","affiliation":[{"name":"Young-Otolaryngologists of the International Federation of Oto-Rhino-Laryngological Societies (YO-IFOS), Research Study Group, 75000 Paris, France"},{"name":"Department of Otolaryngology, Polyclinique de Poitiers, Elsan Hospital, 86000 Poitiers, France"},{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), 91190 Paris, France"},{"name":"Department of Human Anatomy and Experimental Oncology, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), 7000 Mons, Belgium"},{"name":"Department of Otolaryngology\u2014Head & Neck Surgery, CHU Saint-Pierre (CHU de Bruxelles), 1000 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jvoice.2008.09.006","article-title":"Use of Lasers in Laryngeal Surgery","volume":"24","author":"Yan","year":"2010","journal-title":"J. Voice"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/MLG.0b013e31816902bb","article-title":"Predicting Clinical Efficacy of Photoangiolytic and Cutting\/Ablating Lasers Using the Chick Chorioallantoic Membrane Model: Implications for Endoscopic Voice Surgery","volume":"118","author":"Burns","year":"2008","journal-title":"Laryngoscope"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/lsm.1900010310","article-title":"Microvasculature Can Be Selectively Damaged Using Dye Lasers: A Basic Theory and Experimental Evidence in Human Skin","volume":"1","author":"Anderson","year":"1981","journal-title":"Lasers Surg. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/00005537-199807000-00003","article-title":"A 585-Nanometer Pulsed Dye Laser Treatment of Laryngeal Papillomas: Preliminary Report","volume":"108","author":"McMillan","year":"1998","journal-title":"Laryngoscope"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst. Rev."},{"key":"ref_6","first-page":"1057","article-title":"Using PICO to Align Medical Evidence with MDs Decision Making Models","volume":"192","author":"Wilk","year":"2013","journal-title":"Stud. Health Technol. Inf."},{"key":"ref_7","unstructured":"OCEBM Levels of Evidence Working Group (2023, August 15). The Oxford 2011 Levels of Evidence. Available online: http:\/\/www.cebm.net\/index.aspx?o=5653."},{"key":"ref_8","unstructured":"National Institute for Health and Care Excellence (2012). Methods for the Development of NICE Public Health Guidance, National Institute for Health and Care Excellence (NICE). Process and Methods Guides No. 4."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/MOO.0b013e32833f890d","article-title":"Pulse Dye and Other Laser Treatments for Vocal Scar","volume":"18","author":"Prufer","year":"2010","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s40136-015-0091-z","article-title":"In-Office Laryngeal Laser Treatment","volume":"3","author":"Fritz","year":"2015","journal-title":"Curr. Otorhinolaryngol. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MOO.0b013e3281574582","article-title":"Office-Based Laryngeal Laser Surgery with Local Anesthesia","volume":"15","author":"Zeitels","year":"2007","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/lsm.20839","article-title":"Pulsed Dye Laser-Induced Inflammatory Response and Extracellular Matrix Turnover in Rat Vocal Folds and Vocal Fold Fibroblasts","volume":"41","author":"Lin","year":"2009","journal-title":"Lasers Surg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s00405-015-3887-z","article-title":"Photocoagulation Therapy for Laryngeal Dysplasia Using Angiolytic Lasers","volume":"273","author":"Kishimoto","year":"2016","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s10103-021-03462-3","article-title":"Photodynamic Therapy for Squamous Cell Carcinoma of the Head and Neck: Narrative Review Focusing on Photosensitizers","volume":"37","author":"Ibarra","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical Development and Potential of Photothermal and Photodynamic Therapies for Cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s40136-016-0117-1","article-title":"OR Management of Recurrent Respiratory Papilloma","volume":"4","author":"Bowen","year":"2016","journal-title":"Curr. Otorhinolaryngol. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10103-010-0834-5","article-title":"Transoral Laser Microsurgery for Laryngeal Cancer: A Primer and Review of Laser Dosimetry","volume":"26","author":"Rubinstein","year":"2011","journal-title":"Lasers Med. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s40136-014-0065-6","article-title":"Lasers in the Treatment of Vascular Anomalies","volume":"2","author":"Rosenberg","year":"2014","journal-title":"Curr. Otorhinolaryngol. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s00405-005-1013-3","article-title":"Treatment of Recurrent Respiratory Papillomatosis with Microsurgery in Combination with Intralesional Cidofovir\u2014A Prospective Study","volume":"263","author":"Dikkers","year":"2006","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1177\/000348940611500905","article-title":"Office-Based 532-Nm Pulsed KTP Laser Treatment of Glottal Papillomatosis and Dysplasia","volume":"115","author":"Zeitels","year":"2006","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1001\/archoto.2011.178","article-title":"Using 5-Aminolevulinic Acid and Pulsed Dye Laser for Photodynamic Treatment of Oral Leukoplakia","volume":"137","author":"Shafirstein","year":"2011","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/lary.25795","article-title":"Is Recurrent Respiratory Papillomatosis a Manageable or Curable Disease?","volume":"126","author":"Kim","year":"2016","journal-title":"Laryngoscope"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1096-9101(1999)25:1<51::AID-LSM7>3.0.CO;2-Y","article-title":"Long-Pulse Dye Laser for Photodynamic Therapy: Investigations In Vitro and In Vivo","volume":"25","author":"Karrer","year":"1999","journal-title":"Lasers Surg. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/000348940611500802","article-title":"Pulsed Angiolytic Laser Treatment of Ectasias and Varices in Singers","volume":"115","author":"Zeitels","year":"2006","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"262.e9","DOI":"10.1016\/j.jvoice.2013.08.010","article-title":"Office-Based Pulsed-Dye Laser Surgery for Laryngeal Lesions: A Retrospective Review","volume":"28","author":"Centric","year":"2014","journal-title":"J. Voice"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/00016480701787828","article-title":"Office-Based 585 Nm Pulsed Dye Laser Treatment for Vocal Polyps","volume":"128","author":"Kim","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/000348940811700505","article-title":"Office Pulsed Dye Laser Treatment for Benign Laryngeal Vascular Polyps: A Preliminary Study","volume":"117","author":"Ivey","year":"2008","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.otohns.2007.02.003","article-title":"In-Office Laryngeal Surgery with the 585 nm Pulsed Dye Laser (PDL)","volume":"137","author":"Mouadeb","year":"2007","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.anl.2014.05.013","article-title":"Phonatory Outcome of 585 Nm\/Pulsed-Dye Laser in the Management of Glottic Leukoplakia","volume":"41","author":"Park","year":"2014","journal-title":"Auris Nasus Larynx"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jvoice.2005.08.015","article-title":"Ultrastructural Evaluation of 585-Nm Pulsed-Dye Laser-Treated Glottal Dysplasia","volume":"21","author":"Ayala","year":"2007","journal-title":"J. Voice"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/lary.26445","article-title":"Serial In-Office Laser Treatment of Vocal Fold Leukoplakia: Disease Control and Voice Outcomes","volume":"127","author":"Koss","year":"2017","journal-title":"Laryngoscope"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.otohns.2007.02.041","article-title":"Office-Based Laryngeal Laser Surgery: A Review of 443 Cases Using Three Wavelengths","volume":"137","author":"Koufman","year":"2007","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.otohns.2007.01.026","article-title":"Aminolevulinic Acid 585 Nm Pulsed Dye Laser Photodynamic Treatment of Laryngeal Keratosis with Atypia","volume":"136","author":"Franco","year":"2007","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.otohns.2006.01.019","article-title":"Patient Tolerance of In-Office Pulsed Dye Laser Treatments to the Upper Aerodigestive Tract","volume":"134","author":"Rees","year":"2006","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/000348940411300403","article-title":"Office-Based Treatment of Glottal Dysplasia and Papillomatosis with the 585-Nm Pulsed Dye Laser and Local Anesthesia","volume":"113","author":"Zeitels","year":"2004","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/000348940511400305","article-title":"Pulsed Dye Laser Treatment of Laryngeal Granulomas","volume":"114","author":"Clyne","year":"2005","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1097\/MLG.0b013e31817d7546","article-title":"The Use of the Pulse Dye Laser in the Treatment of Vocal Fold Scar: A Preliminary Study","volume":"118","author":"Mortensen","year":"2008","journal-title":"Laryngoscope"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1001\/archotol.133.2.127","article-title":"Efficacy of Treating Children with Anterior Commissure and True Vocal Fold Respiratory Papilloma with the 585-Nm Pulsed-Dye Laser","volume":"133","author":"Hartnick","year":"2007","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1177\/000348940211100603","article-title":"585-Nm Pulsed Dye Laser Treatment of Glottal Papillomatosis","volume":"111","author":"Franco","year":"2002","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1067\/mhn.2001.113944","article-title":"A New Laser Treatment for Vocal Cord Papilloma\u2014585-Nm Pulsed Dye","volume":"124","author":"Valdez","year":"2001","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.amjoto.2016.08.007","article-title":"Pulsed Dye Laser Treatment of Primary Cryptococcal Laryngitis: A Novel Approach to an Uncommon Disease","volume":"37","author":"Ihenachor","year":"2016","journal-title":"Am. J. Otolaryngol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/000348940711600108","article-title":"Cost Savings of Unsedated Office-Based Laser Surgery for Laryngeal Papillomas","volume":"116","author":"Rees","year":"2007","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4S","DOI":"10.1177\/0145561319899183","article-title":"The Use of 532-Nanometer-Pulsed Potassium-Titanyl-Phosphate (KTP) Laser in Laryngology: A Systematic Review of Current Indications, Safety, and Voice Outcomes","volume":"100","author":"Lechien","year":"2021","journal-title":"Ear Nose Throat J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"105S","DOI":"10.1177\/0145561320960544","article-title":"Applications of Office-Based 445 Nm Blue Laser Transnasal Flexible Laser Surgery: A Case Series and Review of Practice","volume":"100","author":"Miller","year":"2021","journal-title":"Ear Nose Throat J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.anl.2019.01.008","article-title":"Feasibility of Transnasal Flexible Carbon Dioxide Laser Surgery for Laryngopharyngeal Lesions","volume":"46","author":"Araki","year":"2019","journal-title":"Auris Nasus Larynx"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/lary.25653","article-title":"A Cost and Time Analysis of Laryngology Procedures in the Endoscopy Suite versus the Operating Room","volume":"126","author":"Hillel","year":"2016","journal-title":"Laryngoscope"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1046\/j.0022-202X.2004.22241.x","article-title":"Mechanisms of Microvascular Response to Laser Pulses","volume":"122","author":"Suthamjariya","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"(2007). Letters to the Editor. Ann. Otol. Rhinol. Laryngol., 116, 317\u2013318.","DOI":"10.1177\/000348940711600417"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/MOO.0b013e3282f19ef2","article-title":"In-Office Laryngeal Surgery with the 585-Nm Pulsed Dye Laser","volume":"15","author":"Franco","year":"2007","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/9\/1374\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:50:35Z","timestamp":1760129435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/13\/9\/1374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["jpm13091374"],"URL":"https:\/\/doi.org\/10.3390\/jpm13091374","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]}}}