{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:24:41Z","timestamp":1791231881071,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Duration of untreated illness (DUI)\u2014defined as the time period between the onset of a mental disorder and its first adequate treatment\u2014should influence patients\u2019 long-term prognosis and outcome. In patients with obsessive\u2013compulsive disorder (OCD), DUI lasts on average from 87.5 up to 94.5 months, being significantly longer compared with data available from patients affected by other severe mental disorders, such as schizophrenia and bipolar disorder. We carried out a systematic review in order to assess the impact of DUI on long-term outcomes in OCD patients. Methods: A systemic review has been implemented, searching from inception to April 2023; only papers written in English were included. Results: Seventy-one articles were initially identified; only eight papers were included in the review. The DUI ranged from 7.0 \u00b1 8.5 to 20.9 \u00b1 11.2 years. Patients reporting a longer DUI have a poor long-term outcome in terms of lower level of treatment response and greater symptom severity. Conclusions: The present review confirms that longer DUI has a negative impact on the long-term outcome of patients with OCD. It should be useful to promote the dissemination of early interventions with a specific focus on OCD symptoms.<\/jats:p>","DOI":"10.3390\/jpm13101453","type":"journal-article","created":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:57:06Z","timestamp":1696179426000},"page":"1453","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Duration of Untreated Illness in Patients with Obsessive\u2013Compulsive Disorder and Its Impact on Long-Term Outcome: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-0524","authenticated-orcid":false,"given":"Francesco","family":"Perris","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-9020","authenticated-orcid":false,"given":"Salvatore","family":"Cipolla","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9990-5654","authenticated-orcid":false,"given":"Pierluigi","family":"Catapano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Sampogna","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4338-1371","authenticated-orcid":false,"given":"Mario","family":"Luciano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Giallonardo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Del Vecchio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Fabrazzo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Catapano","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Campania \u201cL. 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