{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:41:58Z","timestamp":1789764118364,"version":"4.0.1"},"reference-count":51,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Non-invasive scar management typically involves pressure therapy, hydration with silicones or moisturizers, and UV protection. Moisture loss from scars can lead to hypertrophic scar formation. Pressure therapy reduces blood flow, fibroblast activity, and transforming growth factor beta 1 (TGF-\u03b21) release. This study examined various moisturizers and liquid silicone gel\u2019s impact on microcirculation. 40 volunteers participated in a study where superficial abrasions were created to induce trans epidermal water loss (TEWL). Five moisturizers (TEDRA\u00ae, TEDRA\u00ae NT1, TEDRA\u00ae NT3, Alhydran\u00ae, Lipikar\u00ae) and BAP Scar Care\u00ae silicone gel were tested. TEWL, hydration, and blood flow were measured up to 4 h post-application. Results showed that silicone had the least impact on occlusion and hydration. Alhydran\u00ae reduced blood flow the most, while Lipikar\u00ae increased it the most. TEDRA\u00ae NT1 had reduced flow compared to TEDRA\u00ae and TEDRA\u00ae NT3. All TEDRA\u00ae products exhibited high hydration, and all but silicone showed good occlusion. Moisturizers influenced skin microcirculation, with some causing decrease, while others increased flow. However, the clinical impact on scarring remains unclear compared to the evident effects of hydration and occlusion. More research is necessary to study moisturizers alone and with pressure therapy on scars, along with potential adverse effects of increased microcirculation on scars.<\/jats:p>","DOI":"10.3390\/jpm13101507","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:55:06Z","timestamp":1697622906000},"page":"1507","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of Moisturizers on Skin Microcirculation: An Assessment Study Using Laser Speckle Contrast Imaging"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-8661","authenticated-orcid":false,"given":"Ignace","family":"De Decker","sequence":"first","affiliation":[{"name":"Burn Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"},{"name":"Department of Plastic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-4821","authenticated-orcid":false,"given":"Tanja","family":"Klotz","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia"},{"name":"Department of Occupational Therapy, Royal Adelaide Hospital, Port Rd., Adelaide, SA 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vu","sequence":"additional","affiliation":[{"name":"SA Pharmacy, Royal Adelaide Hospital, Adelaide, SA 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Hoeksema","sequence":"additional","affiliation":[{"name":"Burn Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"},{"name":"Department of Plastic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"De Mey","sequence":"additional","affiliation":[{"name":"Burn Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anse","family":"Beeckman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Sint-Pietersnieuwsstraat 33, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Ziekenhuis Oost-Limburg, Synaps Park 1, 3600 Genk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-4390","authenticated-orcid":false,"given":"Marijn","family":"Speeckaert","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Blondeel","sequence":"additional","affiliation":[{"name":"Burn Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"},{"name":"Department of Plastic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-3720","authenticated-orcid":false,"given":"Marcus","family":"Wagstaff","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia"},{"name":"Adult Burns Service and Department of Plastic Surgery, Royal Adelaide Hospital, Port Rd., Adelaide, SA 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Monstrey","sequence":"additional","affiliation":[{"name":"Burn Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"},{"name":"Department of Plastic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5960-6248","authenticated-orcid":false,"given":"Karel E. Y.","family":"Claes","sequence":"additional","affiliation":[{"name":"Burn Center, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"},{"name":"Department of Plastic Surgery, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.burns.2017.01.021","article-title":"Moisturisers in scar management following burn: A survey report","volume":"43","author":"Klotz","year":"2017","journal-title":"Burns"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1524-4725.2008.34406.x","article-title":"Hypertrophic scars and keloids\u2014A review of their pathophysiology, risk factors, and therapeutic management","volume":"35","author":"Wolfram","year":"2009","journal-title":"Dermatol. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1001\/archderm.1996.03890360039008","article-title":"Functional analysis of the stratum corneum in scars","volume":"132","author":"Suetake","year":"1996","journal-title":"Arch. 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